丙泊酚輸注綜合征ppt課件

1、1Parke TJ, Stevens JE, Rice AS, Greenaway CL, Bray RJ, Smith PJ, et al. Metabolic acidosis and fatal myocardial failure after propofol infusion in children: five case reports. BMJ 1992;305:613-6. Bray RJ. Propofol infusion syndrome in children. Paediatr Anaesth 1998;8:491-9.Marinella MA . Lactic aci

2、dosis associated with propofol. Chest. 1996 Jan;109(1):292. Hanna JP, Ramundo ML. Neurology 1998; 50: 3013Cremer OL, Moons KGM. Lancet 2001; 357: 1178Marinella MA . Lactic acidosis associated with propofol. Chest. 1996 Jan;109(1):292. Hanna JP, Ramundo ML. Rhabdomyolysis and hypoxia associated with

3、prolonged propofol infusion in children. Neurology 1998; 50: 30131. Stelow EB, Johari VP. Clin Chem 46:577582. Kelly DF (2001). Neurosurg 95:9259263. Friedman JA, Manno E. J Neurosurg 96:116111624. Perrier ND, Baerga-Varela Y. Crit Care Med 28:307130745. Cremer OL, Moons KGM, Bouman. Lancet 357:117118。呼吸鏈?zhǔn)怯梢幌盗械倪f氫體和遞電子體按一定的順序排列所組成的連續(xù)反應(yīng)體系，它將代謝物脫下的成對(duì)氫原子傳遞給氧生成水，同時(shí)生成ATP呼吸鏈的作用代表著線粒體最基本的功能丙泊酚具有解耦聯(lián)作用，降低線粒體氧化磷酸化功能，線粒體呼吸鏈酶活性的缺陷，能量供應(yīng)減少，導(dǎo)致心肌和周圍肌肉壞死、溶解，嚴(yán)重的代謝性酸中毒，血清乳酸濃度明顯升高減弱肌肉組織中線粒體內(nèi)細(xì)胞色素氧化酶的活性，從而引起細(xì)胞凋亡，乳酸酸中毒 室性心律失常，心動(dòng)過緩，低血壓，心肌收縮力降低，循環(huán)衰竭少尿，肌紅蛋白尿，肉眼血尿