Scalablearchitectureinmammalianbrains在哺乳動物的大腦可擴展的體系結構學習教案

1、會計學1Scalablearchitectureinmammalianbrains在哺乳動物的大腦在哺乳動物的大腦(dno)可擴展的體可擴展的體系結構系結構第一頁，共42頁。第1頁/共41頁第二頁，共42頁。Abbott and Nelson,Nat. Neurosci.第2頁/共41頁第三頁，共42頁。第3頁/共41頁第四頁，共42頁。CA3-CA1 synapse of hippocampusRich history of extracellular and single-cell recordingThe cell biology and plasticity literature is

2、 vastOne synapse per connectionHas AMPA, NMDA, mGluR,第4頁/共41頁第五頁，共42頁。第5頁/共41頁第六頁，共42頁。第6頁/共41頁第七頁，共42頁。Nishiyama et al. 2000 Nature 408:58480 pairings at 5 Hz Cesium pipet solutionPike et al. 1999Journal of Physiology 518:57140 pairings at 5 Hz Four epochs (10 pairings each) at 10-s intervalsChrist

3、ie et al. 1996Learning and Memory 3:160900 pairings at 3 HzEpochs (30-60 pairings each) at 5-s intervalsAt the CA3-CA1 synapse, pairing single APs givesLTP.no change.LTD.第7頁/共41頁第八頁，共42頁。Single pre+post APs100 pairings with Dt=0-7 ms (pre before post)Pairing frequency 0.1-5 Hz第8頁/共41頁第九頁，共42頁。In Nis

4、hiyama et al. Cesium replaced Potassiumin the intracellular pipette solutionThis will-depolarize neuron -block A-type K channels in dendrite-broaden action potentials第9頁/共41頁第十頁，共42頁。PotassiumCesiumCs+K+pairings given at 5 Hz第10頁/共41頁第十一頁，共42頁。Cs+K+can bursts of APs emulate Cs+?第11頁/共41頁第十二頁，共42頁。LT

5、P induction requires postsynaptic bursting第12頁/共41頁第十三頁，共42頁。CA1 neurons fire bursts during theta oscillation第13頁/共41頁第十四頁，共42頁。Pairings must be given at high frequencyDt第14頁/共41頁第十五頁，共42頁。第15頁/共41頁第十六頁，共42頁。All pairings given at 5 Hz第16頁/共41頁第十七頁，共42頁。第17頁/共41頁第十八頁，共42頁。RequirementThetaBurstingLTP

6、yes yesLTD no no第18頁/共41頁第十九頁，共42頁。第19頁/共41頁第二十頁，共42頁。Why not explore parameter space exhaustively?because its exhausting!第20頁/共41頁第二十一頁，共42頁。Shy ShohamUncaging in spatial patterns: High-throughput screening of neural responsesResolution: 1 Hz10 Hz10 Hz第36頁/共41頁第三十七頁，共42頁。butdissectable?Complex第37頁/共41頁第三十八頁，共42頁。第38頁/共41頁第三十九頁，共42頁。第39頁/共41頁第四十頁，共42頁。第40頁/共41頁第四十一頁，共42頁。NoImage內容(nirng)總結會計學。Abbott and Nelson,。Nat. Neurosci.。at 5-s intervals。-broaden action