Febuxostat-TEI-6720-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEFebuxostatCat. No.: HY-14268CAS No.: 144060-53-7Synonyms: TEI 6720; TMX 67分式: CHNOS分量: 316.37作靶點: Xanthine Oxidase作通路: Metabolic Enzyme/Protease儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO

2、 : 50 mg/mL (158.04 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.1609 mL 15.8043 mL 31.6086 mL5 mM 0.6322 mL 3.1609 mL 6.3217 mL10 mM 0.3161 mL 1.5804 mL 3.1609 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍福渲魄罢埾扰渲瞥吻宓膬湟?，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實

3、驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (7.90 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE物活性 Febuxostat(TEI 6720;TMX 67 )是選擇性黃嘌呤氧化酶（XO）抑制劑，Ki為0.6 nM。戶使本產(chǎn)品發(fā)表的科研獻 Harvard Medical

4、 School LINCS LIBRARYSee more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Takano Y, et al. Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase. Life Sci, 2005,76(16), 1835-1847.2. Snchez-Lozada LG, et al. Effects of febuxostat on metabo

5、lic and renal alterations in rats with fructose-induced metabolic syndrome.Am J Physiol Renal Physiol, 2008, 294(4), F710-F718.3. Snchez-Lozada LG, et al. Effect of febuxostat on the progression of renal disease in 5/6 nephrectomy rats with and withouthyperuricemia. Nephron Physiol, 2008, 108(4), p6

6、9-p78.4. Xu X, et al. Xanthine oxidase inhibition with febuxostat attenuates systolic overload-induced left ventricular hypertrophy and dysfunctionin mice. Card Fail, 2008, 14(9), 746-753.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820