NVP-BVU972-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemENVP-BVU972Cat. No.: HY-15456CAS No.: 1185763-69-2分式: CHN分量: 340.38作靶點(diǎn): c-Met/HGFR作通路: Protein Tyrosine Kinase/RTK儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 42 mg/mL (123.39 mM)* means

2、soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.9379 mL 14.6895 mL 29.3789 mL5 mM 0.5876 mL 2.9379 mL 5.8758 mL10 mM 0.2938 mL 1.4689 mL 2.9379 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 NVP-BVU972活性Met抑制劑，IC50為14 nM，對(duì)其它的激酶抑制性較低。REFERENC

3、ES1. Tiedt, Ralph, et al. A Drug Resistance Screen Using a Selective MET Inhibitor Reveals a Spectrum of Mutations That Partially Overlapwith Activating Mutations Found in Cancer Patients. Cancer Research (2011), 71(15), 5255-5264.1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE2. Shin JS, et al. NPS-1034, a novel MET inhibitor, inhibits the activated MET receptor and its constitutively active mutants. Invest NewDrugs. 2013 Oct 31.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 021-5370