Docosatrienoic-Acid-cis-13-16-19-docosatrienoic-acid-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDocosatrienoic AcidCat. No.: HY-101408CAS No.: 28845-86-5Synonyms: cis-13,16,19-docosatrienoic acid; (13Z,16Z,19Z)-13,16,19-Docosatrienoic acid分式: CHO分量: 334.54作靶點(diǎn): Endogenous Metabolite作通路: Metabolic Enzyme/Protease儲(chǔ)存式: Pure fo

2、rm -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) Ethanol : 100 mg/mL (298.92 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.9892 mL 14.9459 mL 29.8918 mL5 mM 0.5978 mL 2.9892 mL 5.9784 mL10 mM 0.2989 mL 1.4946 mL 2.9892 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并

3、請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Docosatrienoic acid是罕見(jiàn)的-3脂肪酸; 抑制LTB4與中性粒細(xì)胞膜的結(jié)合的Ki值為5 M。IC50 & Target Human Endogenous Metabolite體外研究 Docosatrienoic acid inhibits LTB4 binding to pig neutrophil membranes with an Ki of 5 M 1.1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE體內(nèi)研究 Application of doc

4、osatrienic acid dose-dependently decreases the peak K+ current amplitide and acceleratesthe potassium activation and inactivation kinetics at all rat membrane potentials 2.REFERENCES1. Yagaloff KA, et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins Leukot Ess

5、ent Fatty Acids. 1995May;52(5):293-7.2. Krutetskaia ZI, et al. The effect of docosatrienoic acid on the potassium channels of outward rectification in the membrane of ratperitoneal macrophages. Fiziol Zh Im I M Sechenova. 1995 Jul;81(7):111-9.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-58