Protein-degrader-1-hydrochloride - Ligand for E3 Ligase - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEProtein degrader 1 hydrochlorideCat. No.: HY-101763ACAS No.: 1448189-80-7分式: CHClNOS分量: 467.02作靶點(diǎn): Ligand for E3 Ligase作通路: PROTAC儲(chǔ)存式: 4C, stored under nitrogen* In solvent : -80C, 6 months; -20C, 1 month (stored undernitrogen)溶

2、解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 150 mg/mL (321.19 mM; Need ultrasonic)H2O : 50 mg/mL (107.06 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.1412 mL 10.7062 mL 21.4124 mL5 mM 0.4282 mL 2.1412 mL 4.2825 mL10 mM 0.2141 mL 1.0706 mL 2.1412 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)

3、您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.35 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.35

4、mM); Clear solution3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.35 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Protein degrader 1 hydrochlorideVHL 的種分配體，VHL 種 E3 連接酶，可被泛于 PROTAC技術(shù)研究中。IC50 & Target E3 ligase VHL 1體外研究 Synthesis of HaloPROT

5、ACs contains Protein degrader 1 (Degradation Inducing Moiety A). Protein degrader1 (Degradation Inducing Moiety A) is capable of inducing the degradation of GFP-HaloTag7 in cell-basedassays. HaloPROTACs containing Protein degrader 1 (Degradation Inducing Moiety A) lead to nearly 70%degradation of GF

6、P-HaloTag7, when sufficiently long linkers are used 1.REFERENCES1. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins.ACS ChemBiol. 2015 Aug 21;10(8):1831-7.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-82