Sarpogrelate-hydrochloride-MCI-9042-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESarpogrelate hydrochlorideCat. No.: HY-10564CAS No.: 135159-51-2Synonyms: MCI-9042分式: CHClNO分量: 465.97作靶點(diǎn): 5-HT Receptor作通路: GPCR/G Protein; Neuronal Signaling儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 mont

2、h溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 62 mg/mL (133.06 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.1461 mL 10.7303 mL 21.4606 mL5 mM 0.4292 mL 2.1461 mL 4.2921 mL10 mM 0.2146 mL 1.0730 mL 2.1461 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，?/p>

3、制前請(qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.37 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.37 mM); Clear solution1

4、/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.37 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Sarpogrelate hydrochloride (MCI-9042)5-HT2拮抗劑，可作抗板類化合物。戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Exp Neurol. 2019 Aug 1:113030.See more customer validations on HYPERLINK / www.M

5、edChemEREFERENCES1. Nishio, H., A. Inoue, and Y. Nakata, Binding affinity of sarpogrelate, a new antiplatelet agent, and its metabolite for serotonin receptorsubtypes. Arch Int Pharmacodyn Ther, 1996. 331(2): p. 189-202.2. Pertz, H. and S. Elz, In-vitro pharmacology of sarpogrelate and the enantiome

6、rs of its major metabolite: 5-HT2A receptor specificity,stereoselectivity and modulation of ritanserin-induced depression of 5-HT contractions in rat tail artery. J Pharm Pharmacol, 1995. 47(4): p.310-6.3. Miyazaki, M., et al., Sarpogrelate hydrochloride, a selective 5-HT2A antagonist, improves vascular function in patients with peripheralarterial disease. J Cardiovasc Pharmacol, 2007. 49(4): p. 221-7.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Te