Mirin-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMirinCat. No.: HY-19959CAS No.: 1198097-97-0分式: CHNOS分量: 220.25作靶點: Others作通路: Others儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 31 mg/mL (140.75 mM)* means soluble, but saturation unkn

2、own.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 4.5403 mL 22.7015 mL 45.4030 mL5 mM 0.9081 mL 4.5403 mL 9.0806 mL10 mM 0.4540 mL 2.2701 mL 4.5403 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Mirin分MRN（Mre11，Rad50，和Nbs1）復合物的抑制劑。REFERENCES1. Rozier L, et al. The MRN-CtIP

3、 pathway is required for metaphase chromosome alignment. Mol Cell. 2013 Mar 28;49(6):1097-107.1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE2. Lee JH, et al. Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in theMre11/Rad50/Nbs1 (MRN) complex.

4、 J Biol Chem. 2013 May 3;288(18):12840-51.3. Garner KM, et al. Corrected structure of Mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol. 2009Mar;5(3):129-30.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 021-5