R-268712 - TGF-β Receptor 抑制劑 - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemER-268712Cat. No.: HY-12953CAS No.: 879487-87-3分式: CHFNO分量: 363.39作靶點(diǎn): TGF- Receptor作通路: TGF-beta/Smad儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 125 mg/mL (343.98 mM; Need ultrasonic)Ma

2、ss Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.7519 mL 13.7593 mL 27.5186 mL5 mM 0.5504 mL 2.7519 mL 5.5037 mL10 mM 0.2752 mL 1.3759 mL 2.7519 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的

3、百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (5.72 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (5.72 mM); Clear solution3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (5.72 mM); Clear sol

4、ution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 R-268712種有效的選擇性ALK5抑制劑, IC50為2.5 nM。REFERENCES1. Terashima H, et al. R-268712, an orally active transforming growth factor- type I receptor inhibitor, prevents glomerular sclerosis in aThy1 nephritis model. Eur J Pharmacol. 2014 Jul 5;734:60-6.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: