Mertansine-DM1-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMertansineCat. No.: HY-19792CAS No.: 139504-50-0Synonyms: DM1; Maytansinoid DM1分式: CHClNOS分量: 738.29作靶點: Microtubule/Tubulin; ADC Cytotoxin作通路: Cell Cycle/DNA Damage; Cytoskeleton; Antibody-drugConjugate/ADC Related儲存式: Powder -

2、20C 3 years4C 2 years* 該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)現(xiàn)配，即刻使。溶解性數(shù)據(jù)體外實驗 DMSO : 83.33 mg/mL (112.87 mM)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.17 mg/mL (2.94 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.17 mg/mL (2.94

3、mM); Suspended solution; Need ultrasonic3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.17 mg/mL (2.94 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Mertansine (DM1)種微管蛋抑制劑，也 種抗體可綴合的美登素物堿，于克服與美登素相關的全毒性并增強腫瘤特異性遞送。Mertansine 可以通過連接體連接到單克隆抗體上，形成抗體藥物結(jié)合物(ADC) 1 2。戶使本產(chǎn)品發(fā)表的科研獻 ACS Chem Biol. 2018 Mar 16;13(3)

4、:761-771. bioRxiv. 2019 Jan.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Manu Lopus et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamicsby Binding to Microtubules.2. Lopus M. Antibody-DM1 conjugates as cancer therapeutics. Cancer Lett. 2011 Aug 28;307(2):113-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fa