E-AG-99-E-Tyrphostin-46-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE(E)-AG 99Cat. No.: HY-100962CAS No.: 122520-85-8Synonyms: (E)-Tyrphostin 46; (E)-Tyrphostin AG 99分式: CHNO分量: 204.18作靶點(diǎn): EGFR作通路: JAK/STAT Signaling; Protein Tyrosine Kinase/RTK儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6

2、months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 165 mg/mL (808.11 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 4.8976 mL 24.4882 mL 48.9764 mL5 mM 0.9795 mL 4.8976 mL 9.7953 mL10 mM 0.4898 mL 2.4488 mL 4.8976 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先

3、配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.75 mg/mL (13.47 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.75 mg/mL (13.47 mM); Clear solution1

4、/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 (E)-AG 99 (E)-Tyrphostin 46; (E)-Tyrphostin AG 99)是有效的 EGFR 抑制劑 1。IC50 & Target EGFR體外研究 (E)-AG 99 effectively blocks tyrosine phosphorylation of p145met and promotes cell death accompanied byactivation of caspase-like proteases

5、1.REFERENCES1. Yamamoto N, et al. Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival ofhuman bladder carcinoma cells. J Cell Sci. 2006 Nov 15;119(Pt 22):4623-33.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-589