Tacalcitol-1-24-R-Dihydroxyvitamin-D3-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETacalcitolCat. No.: HY-32337CAS No.: 57333-96-7Synonyms: 1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-DihydroxyvitaminD3分式: CHO分量: 416.64作靶點(diǎn): VD/VDR作通路: Vitamin D Related儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20

2、C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 100 mg/mL (240.02 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.4002 mL 12.0008 mL 24.0015 mL5 mM 0.4800 mL 2.4002 mL 4.8003 mL10 mM 0.2400 mL 1.2001 mL 2.4002 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請根據(jù)您的實(shí)驗(yàn)動物和給藥式選

3、擇適當(dāng)?shù)娜芙獍?，配制前請先配制澄的儲備液，再依次添加助溶?為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.75 mg/mL (6.60 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)1/2 Master of Small Molecules 您邊的抑制劑師www.

4、MedChemESolubility: 2.75 mg/mL (6.60 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.75 mg/mL (6.60 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Tacalcitol (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) 能通過調(diào)節(jié)鈣離促進(jìn)正常長。 China Tropical Medicine. 2013,13(8):944-946.See m

5、ore customer validations on HYPERLINK / www.MedChemEREFERENCES1. Masuo Morisaki , aoyuki Koizumi , Nobuo Ikekawa et al. Synthesis of active forms of vitamin D. Part IX. Synthesis of 1,24-dihydroxycholecalciferol. J. Chem. Soc., Perkin Trans. 1, 1975, 1421-14242. Kiyoshige Ochi , Isao Matsunaga , Hir

6、oyuki Nagano et al. Synthetic studies of vitamin D3 analogues from bile acids. Part 3. Synthesesof 1,25-, 1,24R-, and 1,24S-dihydroxycholecalciferols from lithocholic acid and their biological activities. J. Chem.3. Rostowska-Nadolska et al Vitamin D derivatives: calcitriol and tacalcitol inhibits i

7、nterleukin-6 and interleukin-8 expression in humannasal polyp fibroblasts. Adv.Med.Sci. (2010) 55 86.4. Oiso N, Kawada A.Freckling Promoted by Topical Tacalcitol in a Japanese Boy with Left Eyelid Vitiligo.Pediatr Dermatol. 2011 Oct 20.5. Kobayashi T, Okumura H, Azuma Y, Kiyoki M, Matsumoto K, Hashi

8、moto K, Yoshikawa K.1 alpha,24R-dihydroxyvitamin D3 has an abilitycomparable to that of 1 alpha,25-dihydroxyvitamin D3 to induce keratinocyte differentiation.J Dermatol. 1990 Nov;17(11):707-9.6. Matsumoto K, Hashimoto K, Kiyoki M, Yamamoto M, Yoshikawa K.Effect of 1,24R-dihydroxyvitamin D3 on the growth of humankeratinocytes.J Dermatol. 1990 Feb;17(2):97-103.McePdfHeightCaution: Product has not been fully validated for medical applicati