Adrenergic-Receptor-Antagonists-Modulators-生命科學試劑-MedChemExpress

1、 HYPERLINK https:/www.MedChemE/Targets/Adrenergic Receptor.html Adrenergic HYPERLINK https:/www.MedChemE/Targets/Adrenergic Receptor.html HYPERLINK https:/www.MedChemE/Targets/Adrenergic Receptor.html ReceptorBeta ReceptorAdrenergic receptors are a class of G protein-coupled receptors that are targe

2、ts of the catecholamines, especially norepinephrineand epinephrine. Many cells possess these receptors, and the binding of a catecholamine to the receptor will generally stimulatethe sympathetic nervous system. The sympathetic nervous system is responsible for the fight-or-flight response, which inc

3、ludeswidening the pupils of the eye, mobilizing energy, and diverting blood flow from non-essential organs to skeletal muscle. There aretwo main groups of adrenergic receptors, and , with several subtypes. receptors have the subtypes 1 and 2. receptorshave the subtypes 1, 2 and 3. All three are link

4、ed to Gs proteins, which in turn are linked to adenylate cyclase. Agonist bindingthus causes a rise in the intracellular concentration of the second messenger cAMP. Downstream effectors of cAMP includecAMP-dependent protein kinase (PKA), which mediates some of the intracellular events following horm

5、one binding.www.MedChemE 1 HYPERLINK https:/www.MedChemE/Targets/Adrenergic Receptor.html Adrenergic HYPERLINK https:/www.MedChemE/Targets/Adrenergic Receptor.html HYPERLINK https:/www.MedChemE/Targets/Adrenergic Receptor.html Receptor HYPERLINK https:/www.MedChemE/Targets/Adrenergic Receptor.html H

6、YPERLINK https:/www.MedChemE/Targets/Adrenergic Receptor.html Inhibitors, HYPERLINK https:/www.MedChemE/Targets/Adrenergic Receptor.html HYPERLINK https:/www.MedChemE/Targets/Adrenergic Receptor.html Agonists, HYPERLINK https:/www.MedChemE/Targets/Adrenergic Receptor.html HYPERLINK https:/www.MedChe

7、mE/Targets/Adrenergic Receptor.html Antagonists, HYPERLINK https:/www.MedChemE/Targets/Adrenergic Receptor.html HYPERLINK https:/www.MedChemE/Targets/Adrenergic Receptor.html Activators HYPERLINK https:/www.MedChemE/Targets/Adrenergic Receptor.html HYPERLINK https:/www.MedChemE/Targets/Adrenergic Re

8、ceptor.html & HYPERLINK https:/www.MedChemE/Targets/Adrenergic Receptor.html HYPERLINK https:/www.MedChemE/Targets/Adrenergic Receptor.html Modulators HYPERLINK https:/www.MedChemE/_addition_-Penbutolol.html (+)-Penbutolol(R)-Penbutolol; (+)-Isopenbutolol) Cat. No.: HY-116790A HYPERLINK https:/www.M

9、edChemE/Pyrrolo2,3-cazepine-4,8_1H,5H_-dione,_1-4-4-_4-fluorobenzoyl_-1-piperidinylbutyl-6,7-dihydro-7-methyl-,_4-oxime,_4E_-.html (4E)-SUN9221Cat. No.: HY-U00367(+)-Penbutolol is a -adrenoceptor antagonist,with an IC of 0.74 M. (+)-Penbutolol is anoptical isomer of l-penbutolol with Nachannel-block

10、ing action.(4E)-SUN9221 is a potent antagonist of1-adrenergic receptor and 5-HT2 receptor, withantihypertensive and anti-platelet aggregationactivities.Purity: 95.0%Clinical Data: LaunchedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HY

11、PERLINK https:/www.MedChemE/r-atenolol.html (R)-(+)-AtenololCat. No.: HY-B2111 HYPERLINK https:/www.MedChemE/r-carvedilol.html (R)-Carvedilol(R)-BM 14190) Cat. No.: HY-B0006C(R)-(+)-Atenolol is the less active enantiomer ofthe (R,S)-atenolol. (R,S)-atenolol is a-adrenergic receptor antagonist.(R)-Ca

12、rvedilol (R)-BM 14190), the R-enantiomer ofCarvedilol, is a non-selective /-1 blocker.(R)-Carvedilol exerts protection against thevascular or cardiac toxicity of Doxorubicin (DOX).Purity: 99.0%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mgPurity: 99.05%Clinical Data: No Developm

13、ent ReportedSize: 5 mg, 10 mg HYPERLINK https:/www.MedChemE/r-carvedilol-d4.html (R)-Carvedilol-d4(R)-BM 14190-d4) Cat. No.: HY-B0006CS HYPERLINK https:/www.MedChemE/r-metoprolol-d7.html (R)-Metoprolol-d7Cat. No.: HY-17503S1(R)-Carvedilol-d4 is deuterium labeled(R)-Carvedilol. (R)-Carvedilol (R)-BM

14、14190), theR-enantiomer of Carvedilol, is a non-selective/-1 blocker. (R)-Carvedilol exerts protectionagainst the vascular or cardiac toxicity ofDoxorubicin (DOX).(R)-Metoprolol-d7 is the deuterium labeledMetoprolol. Metoprolol (Toprol) is a selective 1receptor blocker used in treatment of severaldi

15、seases of the cardiovascular system, especiallyhypertension.Purity: 98%Clinical Data:Size: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 10 mg HYPERLINK https:/www.MedChemE/r-propranolol-hydrochloride.html (R)-Propranolol HYPERLINK https:/www.MedChemE/r-propranolol-hydrochlo

16、ride.html HYPERLINK https:/www.MedChemE/r-propranolol-hydrochloride.html hydrochloride HYPERLINK https:/www.MedChemE/r-propranolol-hydrochloride.html HYPERLINK https:/www.MedChemE/r-terazosin.html (R)-TerazosinCat. No.: HY-A0295 Cat. No.: HY-B0371B(R)-Propranolol hydrochloride is a less activeenanti

17、omer of the -adrenoceptorantagonist propranolol (HY-B0573).(R)-Terazosin is an active R-enantiomer ofTerazosin. (R)-Terazosin is a potent1-adrenoceptor antagonist with K values of 6.51nM, 1.01 nM and 1.97 nM for 1a, 1b and1d-adrenoceptor, respectively.Purity: 99.36%Clinical Data: LaunchedSize: 100 m

18、gPurity: 99.77%Clinical Data: LaunchedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/rac-dobutamine-d4-hydrochloride.html (rac)-Dobutamine-d4 HYPERLINK https:/www.MedChemE/rac-dobutamine-d4-hydrochloride.html HYPERLINK https:/www.MedChemE/rac-dobutamine-d4-hydrochloride.h

19、tml hydrochloride HYPERLINK https:/www.MedChemE/rac-dobutamine-d4-hydrochloride.html HYPERLINK https:/www.MedChemE/rac-dobutamine-d6-hydrochloride.html (rac)-Dobutamine-d6 HYPERLINK https:/www.MedChemE/rac-dobutamine-d6-hydrochloride.html HYPERLINK https:/www.MedChemE/rac-dobutamine-d6-hydrochloride

20、.html hydrochlorideCat. No.: HY-15746S Cat. No.: HY-15746S1(Rac)-Dobutamine-d4 hydrochloride is a labelledracemic Dobutamine hydrochloride. Dobutaminehydrochloride is a synthetic catecholamine thatacts on 1-AR, 1-AR, 2-AR (-1, -1 and-2adrenoceptors).(Rac)-Dobutamine-d6 hydrochloride is a labelledrac

21、emic Dobutamine hydrochloride. Dobutaminehydrochloride is a synthetic catecholamine thatacts on 1-AR, 1-AR, 2-AR (-1, -1 and-2adrenoceptors).Purity: 98%Clinical Data:Size: 2.5 mg, 1 mg, 10 mg, 25 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg2 Tel: 609-228-6898 Fax: 609-228-5909

22、 Email: salesMedChemE HYPERLINK https:/www.MedChemE/rac-nebivolol-d4.html (rac)-Nebivolol-d4 HYPERLINK https:/www.MedChemE/rac-nebivolol-d4.html HYPERLINK https:/www.MedChemE/rac-nebivolol-d8.html (rac)-Nebivolol-d8Cat. No.: HY-B0203BS1 Cat. No.: HY-B0203BS(Rac)-Nebivolol-d4 (Rac)-R 065824-d4) is al

23、abelled racemic Nebivolol. Nebivolol selectivelyinhibits 1- adrenergic receptor with IC of 0.8nM.(Rac)-Nebivolol-d8 (rac)-R 065824-d8) is alabelled racemic Nebivolol. Nebivolol selectivelyinhibits 1- adrenergic receptor with IC of 0.8nM.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5

24、mgPurity: 98%Clinical Data:Size: 500 g, 1 mg, 5 mg, 10 mg HYPERLINK https:/www.MedChemE/rac-norepinephrine-d3-formate.html (Rac)-Norepinephrine-d3 HYPERLINK https:/www.MedChemE/rac-norepinephrine-d3-formate.html HYPERLINK https:/www.MedChemE/rac-norepinephrine-d3-formate.html (formate) HYPERLINK htt

25、ps:/www.MedChemE/rac-norepinephrine-d3-formate.html HYPERLINK https:/www.MedChemE/rac-Rotigotine-Hydrochloride.html (Rac)-Rotigotine HYPERLINK https:/www.MedChemE/rac-Rotigotine-Hydrochloride.html HYPERLINK https:/www.MedChemE/rac-Rotigotine-Hydrochloride.html hydrochlorideCat. No.: HY-13715S Cat. N

26、o.: HY-15394(Rac)-Norepinephrine-d3 (formate) is deuteriumlabeled Norepinephrine. Norepinephrine(Levarterenol; L-Noradrenaline) is a potentadrenergic receptor (AR) agonist. Norepinephrineactivates 1, 2, 1 receptors.(Rac)-Rotigotine hydrochloride is a racemate ofRotigotine.Purity: 98%Clinical Data: N

27、o Development ReportedSize: 1 mg, 5 mgPurity: 98.66%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 10 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/rac-rotigotine-d7-hydrochloride.html (Rac)-Rotigotine-d7 HYPERLINK https:/www.MedChemE/rac-rotigotine-d7-hydrochloride.html HYPERLINK https:/

28、www.MedChemE/rac-rotigotine-d7-hydrochloride.html hydrochloride HYPERLINK https:/www.MedChemE/rac-rotigotine-d7-hydrochloride.html HYPERLINK https:/www.MedChemE/_RS_-Butyryltimolol.html (RS)-ButyryltimololCat. No.: HY-15394S Cat. No.: HY-102032A(Rac)-Rotigotine-d7 (hydrochloride) is deuteriumlabeled

29、 (Rac)-Rotigotine (hydrochloride).(Rac)-Rotigotine hydrochloride is a racemate ofRotigotine.(RS)-Butyryltimolol is the racemate ofButyryltimolol. Butyryltimolol, an effectiveprodrug of Timolol, improves the cornealpenetration of Timolol. Butyryltimolol is a-adrenergic blocker.Purity: 98%Clinical Dat

30、a: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/s-minus-propranolol-hydrochloride.html (S)-(-)-Propranolol HYPERLINK https:/www.MedChemE/s-minus-propranolol-hydrochloride.html HYPERL

31、INK https:/www.MedChemE/s-minus-propranolol-hydrochloride.html hydrochloride HYPERLINK https:/www.MedChemE/s-minus-propranolol-hydrochloride.html HYPERLINK https:/www.MedChemE/s-minus-propranolol-d7-hydrochloride.html (S)-(-)-Propranolol-d7 HYPERLINK https:/www.MedChemE/s-minus-propranolol-d7-hydroc

32、hloride.html HYPERLINK https:/www.MedChemE/s-minus-propranolol-d7-hydrochloride.html hydrochlorideCat. No.: HY-B0573A Cat. No.: HY-B0573AS(S)-(-)-Propranolol hydrochloride is a -adrenergicreceptor antagonist with log K values of-8.16, -9.08, and -6.93 for , , and ,respectively.Purity: 97.0%Clinical

33、Data: LaunchedSize: 10 mM 1 mL,(S)-(-)-Propranolol-d7 hydrochloride is thedeuterium labeled (S)-(-)-Propranololhydrochloride. (S)-(-)-Propranolol hydrochlorideis a -adrenergic receptor antagonist with logK values of -8.16, -9.08, and -6.93 for , , and , respectively.Purity: 98%Clinical Data: No Deve

34、lopment ReportedSize: 2.5 mg, 25 mg HYPERLINK https:/www.MedChemE/s-carvedilol.html (S)-Carvedilol HYPERLINK https:/www.MedChemE/s-carvedilol.html HYPERLINK https:/www.MedChemE/s-carvedilol-d4.html (S)-Carvedilol-d4(S)-BM 14190) Cat. No.: HY-B0006B (S)-BM 14190-d4) Cat. No.: HY-B0006BS(S)-Carvedilol

35、, the S-enantiomer of Carvedilol, isa non-selective /-1 blocker. (S)-Carvedilolexerts protection against the vascular or cardiactoxicity of Doxorubicin (DOX).(S)-Carvedilol-d4 is deuterium labeled(S)-Carvedilol. (S)-Carvedilol, the S-enantiomerof Carvedilol, is a non-selective /-1 blocker.(S)-Carved

36、ilol exerts protection against thevascular or cardiac toxicity of Doxorubicin (DOX).Purity: 99.25%Clinical Data: No Development ReportedSize: 5 mg, 10 mgPurity: 98%Clinical Data:Size: 1 mg, 5 mgwww.MedChemE 3 HYPERLINK https:/www.MedChemE/s-metoprolol-d7.html (S)-Metoprolol-d7 HYPERLINK https:/www.M

37、edChemE/s-metoprolol-d7.html HYPERLINK https:/www.MedChemE/s-phenylephrine-d6-hydrochloride.html (S)-Phenylephrine-d6 HYPERLINK https:/www.MedChemE/s-phenylephrine-d6-hydrochloride.html HYPERLINK https:/www.MedChemE/s-phenylephrine-d6-hydrochloride.html hydrochlorideCat. No.: HY-17503S2 Cat. No.: HY

38、-B0471S2(S)-Metoprolol-d7 is the deuterium labeledMetoprolol. Metoprolol (Toprol) is a selective 1receptor blocker used in treatment of severaldiseases of the cardiovascular system, especiallyhypertension.(S)-Phenylephrine-d6 (hydrochloride) is deuteriumlabeled Phenylephrine (hydrochloride).(R)-(-)-

39、Phenylephrine hydrochloride is a selective1-adrenoceptor agonist with pKis of 5.86, 4.87and 4.70 for 1D, 1B and 1A receptorsrespectively.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 10 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/s

40、-terazosin.html (S)-TerazosinCat. No.: HY-B0371D HYPERLINK https:/www.MedChemE/_S_-Timolol-Maleate.html (S)-Timolol HYPERLINK https:/www.MedChemE/_S_-Timolol-Maleate.html HYPERLINK https:/www.MedChemE/_S_-Timolol-Maleate.html Maleate(L-714,465 Maleate; MK 950) Cat. No.: HY-17380(S)-Terazosin is an a

41、ctive S-enantiomer ofTerazosin. (S)-Terazosin is a potent andhigh-affinity -adrenoceptor antagonist with Kvalues of 3.91 nM, 0.79 nM and 1.16 nM for 1a,1b and 1d-adrenoceptor, respectively.(S)-Timolol Maleate (L-714,465 Maleate) is anon-cardioselective hydrophilic -adrenoceptorblocker. (S)-Timolol M

42、aleate is widely used asstandard medication for intraocular pressure(glaucoma) by preventing the production of aqueoushumor.Purity: 99.77%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mgPurity: 99.85%Clinical Data: LaunchedSize: 10 mM 1 mL, 100 mg, 200 mg HYPERLINK

43、https:/www.MedChemE/s-timolol-d9-maleate.html (S)-Timolol-d9 HYPERLINK https:/www.MedChemE/s-timolol-d9-maleate.html HYPERLINK https:/www.MedChemE/s-timolol-d9-maleate.html maleate(L-714,465-d9 maleate; MK 950-d9) Cat. No.: HY-17380S HYPERLINK https:/www.MedChemE/(plusmn)-Befunolol.html ()-Befunolol

44、Cat. No.: HY-101752(S)-Timolol-d9 (maleate) is deuterium labeled(S)-Timolol (Maleate). (S)-Timolol Maleate(L-714,465 Maleate) is a non-cardioselectivehydrophilic -adrenoceptor blocker.()-Befunolol is a -adrenoceptor blocking agent.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPuri

45、ty: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/racemic-penbutolol-d9-hydrochloride.html ()-Penbutolol-d9 HYPERLINK https:/www.MedChemE/racemic-penbutolol-d9-hydrochloride.html HYPERLINK https:/www.MedChemE/racemic-penbutolol-d9-hydrochloride.html hydrochl

46、oride HYPERLINK https:/www.MedChemE/racemic-penbutolol-d9-hydrochloride.html (Rac)-Penbutolol-d9 HYPERLINK https:/www.MedChemE/2-5-dideoxyadenosine.html 2,5-Dideoxyadenosinehydrochloride; ()-Isopenbutolol-d9 hydrochloride) Cat. No.: HY-116790BSACat. No.: HY-135878()-Penbutolol-d9 (Rac)-Penbutolol-d9

47、)hydrochloride is a deuterium labeled()-Penbutolol hydrochloride. (+)-Penbutololhydrochloride is a -adrenoceptor antagonist, withan IC of 0.74 M.2,5-Dideoxyadenosine is a potent andnon-competitive adenylyl cyclase inhibitor viabinding the P-site with an IC of 3 M .2,5-Dideoxyadenosine is a nucleosid

48、e analog andexerts a potent antiadrenergic action in heart.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mgPurity: 99.86%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mg, 250 mg HYPERLINK https:/www.MedChemE/2-methoxyidazoxan-monohydrochlorid

49、e.html 2-Methoxyidazoxan HYPERLINK https:/www.MedChemE/2-methoxyidazoxan-monohydrochloride.html HYPERLINK https:/www.MedChemE/2-methoxyidazoxan-monohydrochloride.html monohydrochloride HYPERLINK https:/www.MedChemE/2-methoxyidazoxan-monohydrochloride.html HYPERLINK https:/www.MedChemE/4-hydroxypropr

50、anolol-hydrochloride.html 4-Hydroxypropranolol HYPERLINK https:/www.MedChemE/4-hydroxypropranolol-hydrochloride.html HYPERLINK https:/www.MedChemE/4-hydroxypropranolol-hydrochloride.html hydrochloride(RX821002 hydrochloride) Cat. No.: HY-103197 ()-4-hydroxy Propranolol hydrochloride) Cat. No.: HY-10

51、06342-Methoxyidazoxan monohydrochloride (RX821002hydrochloride) is a highly selective alpha2-adrenoceptor antagonist with little or noimidazoline antagonist effect.4-Hydroxypropranolol hydrochlorid is an activemetabolite of Propranolol. 4-Hydroxypropranololhydrochlorid is of comparable potency toPro

52、pranolol.Purity: 99.20%Clinical Data: No Development ReportedSize: 10 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg4 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/4-hydroxypropranolol-d7.html 4-Hydroxypropranolol-d7()-4-Hydroxy

53、Propranolol-d7) Cat. No.: HY-100634SA HYPERLINK https:/www.MedChemE/4-hydroxypropranolol-d7-hydrochloride.html 4-Hydroxypropranolol-d7 HYPERLINK https:/www.MedChemE/4-hydroxypropranolol-d7-hydrochloride.html HYPERLINK https:/www.MedChemE/4-hydroxypropranolol-d7-hydrochloride.html hydrochloride()-4-H

54、ydroxy Propranolol-d7 hydrochloride) Cat. No.: HY-100634S4-Hydroxypropranolol-d7 ()-4-HydroxyPropranolol-d7) is the deuterium labeled4-Hydroxypropranolol hydrochloride.4-Hydroxypropranolol hydrochlorid is an activemetabolite of Propranolol.4-Hydroxypropranolol D7 hydrochloride()-4-hydroxy Propranolo

55、l D7 hydrochloride) is adeuterium labeled 4-Hydroxypropranololhydrochloride.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/Pyrrolo3,2-cazepin-4_1H_-one,_5-3-4-_4-fluorophenyl_-1-piperazi

56、nylpropyl-5,6,7,8-tetrahydro-8-hydroxy-1-methyl-.html 5-HT2 HYPERLINK https:/www.MedChemE/Pyrrolo3,2-cazepin-4_1H_-one,_5-3-4-_4-fluorophenyl_-1-piperazinylpropyl-5,6,7,8-tetrahydro-8-hydroxy-1-methyl-.html HYPERLINK https:/www.MedChemE/Pyrrolo3,2-cazepin-4_1H_-one,_5-3-4-_4-fluorophenyl_-1-piperazi

57、nylpropyl-5,6,7,8-tetrahydro-8-hydroxy-1-methyl-.html antagonist HYPERLINK https:/www.MedChemE/Pyrrolo3,2-cazepin-4_1H_-one,_5-3-4-_4-fluorophenyl_-1-piperazinylpropyl-5,6,7,8-tetrahydro-8-hydroxy-1-methyl-.html HYPERLINK https:/www.MedChemE/Pyrrolo3,2-cazepin-4_1H_-one,_5-3-4-_4-fluorophenyl_-1-pip

58、erazinylpropyl-5,6,7,8-tetrahydro-8-hydroxy-1-methyl-.html 1 HYPERLINK https:/www.MedChemE/Pyrrolo3,2-cazepin-4_1H_-one,_5-3-4-_4-fluorophenyl_-1-piperazinylpropyl-5,6,7,8-tetrahydro-8-hydroxy-1-methyl-.html HYPERLINK https:/www.MedChemE/a-61603.html A-61603Cat. No.: HY-U00365 Cat. No.: HY-1013665-H

59、T2 antagonist 1 is a potent antagonist of5-HT2 receptor, with weak 1 adrenoceptorblocking activity.A-61603 is a selective -adrenergic receptoragonist. A-61603 increases the frequency ofspontaneous Ca transients in rat ventricularmyocytes in vitro.Purity: 98%Clinical Data: No Development ReportedSize

60、: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/a55453.html A55453 HYPERLINK https:/www.MedChemE/a55453.html HYPERLINK https:/www.MedChemE/aaptamine.html AaptamineCat. No.: HY-111188 Cat. No.: HY-N4225A55453 is a prazosin analogue and a pot