Tubulin-inhibitor-6-DataSheet-生命科學(xué)試劑-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemETubulininhibitor6Cat.No.:HY-136121CASNo.:105925-39-1分?式:C??H??ClNO?S分?量:367.85作?靶點(diǎn):Microtubule/Tubulin作?通路:CellCycle/DNADamage;Cytoskeleton儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:62.5mg/mL(169.91mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.7185mL13.5925mL27.1850mL5mM0.5437mL2.7185mL5.4370mL10mM0.2718mL1.3592mL2.7185mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存?式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案，配制前請(qǐng)先配制澄的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分?指該溶劑在您配制終溶液中的體積占?)：1.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥6.25mg/mL(16.99mM);ClearsolutionBIOLOGICALACTIVITY?物活性Tubulininhibitor6(Compound14b)?種微管蛋?(tubulin)抑制劑，也多種腫瘤細(xì)胞系的有效抑制劑。1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemETubulininhibitor6抑制微管蛋?聚合，IC50為0.87μM。Tubulininhibitor6抑制K562細(xì)胞?長(zhǎng)，IC50為840nM[1]。IC50&TargetIC50:0.87μM(tubulinpolymerization)[1]體外研究Tubulininhibitor6displayssubmicromolarantiproliferativeactivity[1].REFERENCES[1].PrinzH,etal.N-benzoylatedphenoxazinesandphenothiazines:synthesis,antiproliferativeactivity,andinhibitionoftubulinpolymerization.JMedChem.2011Jun23;54(12):4247-63.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792a