D-Kynurenine-DataSheet-生命科學(xué)試劑-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemED-KynurenineCat.No.:HY-W014502CASNo.:13441-51-5分?式:C??H??N?O?分?量:208.21作?靶點:ArylHydrocarbonReceptor;EndogenousMetabolite作?通路:Immunology/Inflammation;MetabolicEnzyme/Protease儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗H2O:62.5mg/mL(300.18mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM4.8028mL24.0142mL48.0284mL5mM0.9606mL4.8028mL9.6057mL10mM0.4803mL2.4014mL4.8028mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存?式和期限。BIOLOGICALACTIVITY?物活性D-kynurenineD-?氨酸的代謝產(chǎn)物，可以?作健尿酸(KYNA)和3-羥?尿氨酸(3-hydroxykynurenine)的?物前體。D-kynurenineG蛋?偶聯(lián)受體GPR109B的激動劑，D-kynurenineD-氨酸氧化酶熒光分析的底物。D-kynurenine通過激活芳?烴受體(AHR)促進上?細胞向間充質(zhì)細胞的轉(zhuǎn)化。IC50&TargetHumanEndogenousMetabolite體外研究D-kynurenine(10,40,60,and100μM)positivelyregulatesthemetastasisof95Dcells,alungcancercell1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemEline,whichisreduceduponsiRNAAhrtreatment.SignificantenhancementVIMexpressionwasdetectedinthepresenceofD-kynurenine(10and40μM).10μMD-kynureninemarkedlyattenuatesE-cadherinlevel.10μMD-kynurenine-mediatedchangesofVIMandE-cadherinaresubstantiallyattenuatedonsiRNAAhrtreatmentaswell.Theevidences-10/40μMD-kynurenine-inducedup-regulationofCYP1A1,10μMD-kynurenine-inducedincreaseofnucleartransferofAhr,and10/40/60/100μMD-kynurenine-inducedenhancementofDER-luciferaseactivity-indicatedthatD-kynurenineIscapableofactivatingAhrinfact[4].REFERENCES[1].WangXD,etal.AmethodforthedeterminationofD-kynurenineinbiologicaltissues.AnalBioanalChem.2013Dec;405(30):9747-54.[2].Irukayama-TomobeY,etal.AromaticD-aminoacidsactaschemoattractantfactorsforhumanleukocytesthroughaGprotein-coupledreceptor,GPR109B.ProcNatlAcadSciUSA.2009Mar10;106(10):3930-4.[3].KozakiA,etal.FluorimetricassayforD-aminoacidoxidaseactivityinratbrainhomogenatebyusingD-kynurenineasasubstrate.BiosciTrends.2012Oct;6(5):241-7.[4].DuanZ,etal.Promotingepithelial-to-mesenchymaltransitionbyD-kynurenineviaactivatingarylhydrocarbonreceptor.MolCellBiochem.2018Nov;448(1-2):165-173.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresea