水產(chǎn)漁業(yè)免疫刺激劑培訓(xùn)課件

適應(yīng)性免疫系統(tǒng)的主要成員B淋巴細(xì)胞與抗體輔助T淋巴細(xì)胞（Thcells)

與細(xì)胞因子（cytokines)細(xì)胞毒性T淋巴細(xì)胞（cytotoxicTcells,CTL)適應(yīng)性免疫系統(tǒng)的主要成員B淋巴細(xì)胞與抗體1PP感染的細(xì)胞PPP激活的補(bǔ)體系統(tǒng)自然殺傷細(xì)胞激活的NK巨噬細(xì)胞激活的MфMACMACC3bPP感染的細(xì)胞PPP激活的補(bǔ)體系統(tǒng)自然殺傷細(xì)胞激活的NK巨噬2激活的B細(xì)胞激活的CTL細(xì)胞APCsThcellsActivatedTh

B細(xì)胞CTL細(xì)胞PP激活的激活的APCsThcellsActivatedTh3Comparisonofcharacteristicsofchemotherapeutics,vaccinesandimmunostimulantsWhenEfficacySpectrumDurationtherapeuticallyprophylacticallyChemo-vaccineImmuno-Pro-excellentexcellentgoodmiddlelimitedwideshortshortlongComparisonofcharacteristics4免疫刺激劑ImmunostimunantsSyntheticchemicalsLevamisoleFK-565BiologicalsubstancesBacterialderivativesAnimalandplantextracts免疫刺激劑Immunostimunants5·HClLevamisoleAnthelminthicdrugInmammals↑metabolicandphagocyticactivitiesofneutrophils↑

numberofphagocytesandleucocytes↑leveloflsozymeinserum·HClLevamisoleAnthelminthicdr6InCohosalmonandCarpInjectionoflevamisole

+modifiedFreund’scompleteadjuvantincreasedCohosalmon’sresistancetoA.salmonicida.Injectionoflevamisoleincreasedthephagocyticactivityandmyeloperoxidaseactivityofneutrophils,leucocytenumbersandserumlysozymelevelsincarp.InCohosalmonandCarpInject7InRainbowtroutInjectionoflevamisole（0.1-0.5mg/kg）↑ResistancetoVibrioanguillarum↑Phagocyticactivityandchemiluminescanceresponsesofleucocytes↑NKcellactivities↑ConcentrationofcomplementNoeffectswithhighdose（5mg/kg）InRainbowtroutInjectionofl8EffectsoflevamisoleonfishSpleencells↑Phagocyticactivity↑NBTreaction↑Numberofantibody-producingcellsHighdoseNostimulationCompletelysuppressEffectsoflevamisoleonfish9Oraladministrationoflevamisole↑Leucocytenumbers↑Serumlysozymelevels↑ThestimulatedNBTreductionandphagocyticindexofphagocyticcellsOraladministrationoflevamis10ImmersionoflevamisoleCarpin10ug/mlfor24h↑ResistancetoA.hydrophila↑Chemotacticabilityofphagocytes↑PhagocyticactivityandchemiluminescenceRainbowtroutin5ug/mlfor30min↑Phagocyticactivityandindex↑Specificantibodytiters2minlaterinA.salmonicidaO-antigenbacterinImmersionoflevamisoleCarpin11FK-565FK-156Lactoyltetrapeptide,isolatedfromculturesofStreptomycesolivaceogriseus,isactiveagainstmicrobialinfectioninmice.FK-565isthesyntheticderivativeofFK-156.Heptanoyl-y-D-glutamyl-(L)-meso-diaminopimelyl-(D)-alanine，庚酮-谷氨酸-內(nèi)消旋-二氨基庚二基-丙氨酸FK-565FK-15612FK-565inRainbowtroutInjectionofFK-565↑ResistancetoA.salmonicida↑ActivationofphagocyticcellsInjectionofFK-565withY.ruckeriO-antigenorA.salmonicidaO-antigen↑Numberofsplenicantibody-producingcells↑SpecificantibodytitersFK-565inRainbowtroutInjecti13（4）投標(biāo)文件中的設(shè)備、技術(shù)參數(shù)明顯不符合招標(biāo)文件的要求；（3）如只是合同的一部分被終止，其他部分仍應(yīng)繼續(xù)執(zhí)行。a.通過(guò)科學(xué)的統(tǒng)計(jì)方法，說(shuō)明當(dāng)前的生產(chǎn)狀況、質(zhì)量水平，識(shí)別生產(chǎn)工藝質(zhì)量改進(jìn)重點(diǎn)，顯示過(guò)去的工作成效；②縣、區(qū)負(fù)責(zé)人的監(jiān)控，管理：（2）各地級(jí)市場(chǎng)部、人事部要培養(yǎng)后備干部，以備各個(gè)市場(chǎng)各級(jí)人員的被撤職、辭職人員進(jìn)行補(bǔ)充，后備干部要另外登記注冊(cè)，市場(chǎng)部對(duì)后備人員要重點(diǎn)培養(yǎng)。該類(lèi)窗口主要指地區(qū)、(往來(lái))單位類(lèi)別、商品類(lèi)別及會(huì)計(jì)科目等資料中要求進(jìn)行數(shù)據(jù)分級(jí)的編輯窗口。單擊左邊樹(shù)狀窗口中的類(lèi)別，然后就可以在右邊列表狀窗口中對(duì)該類(lèi)所屬的基礎(chǔ)資料進(jìn)行編輯操作。（3）由買(mǎi)方委托經(jīng)賣(mài)方認(rèn)可的法定質(zhì)量檢測(cè)機(jī)構(gòu)進(jìn)行驗(yàn)收，驗(yàn)收合格后由法定質(zhì)量檢測(cè)機(jī)構(gòu)出具驗(yàn)收?qǐng)?bào)告。驗(yàn)收費(fèi)用由買(mǎi)方承擔(dān)，另行支付。5.1.2統(tǒng)計(jì)方法選定的原則2.4充裝前要對(duì)瓶體進(jìn)行檢查，檢查外表面及其焊縫是否存在缺陷、閥座、塞座是否有裂紋、傾斜、塌陷等。(二)團(tuán)組織申報(bào)。擬進(jìn)行換屆的團(tuán)組織，向同級(jí)黨組織和上級(jí)團(tuán)委提出開(kāi)展競(jìng)爭(zhēng)上崗的申請(qǐng)，經(jīng)同意后按照領(lǐng)導(dǎo)小組辦公室的統(tǒng)一安排組織實(shí)施。4.6.2崗位職責(zé)范圍，應(yīng)知應(yīng)會(huì)；Polysaccharidesβ-glucanChitinChitosanOligosaccharideLentinanSchizophyllan（4）投標(biāo)文件中的設(shè)備、技術(shù)參數(shù)明顯不符合招標(biāo)文件的要求；P14Beta-1,3-DglucanBeta-1,3-Dglucan15Zymosan酵母聚糖Thenudecellwallofsaccharomycescerevisiae

1940'sDr.PillemerLouisAnti-tumoreffectinmouse

Proteins,lipidsandotherimpuritiesToxityandside-effectsZymosan酵母聚糖16ZymocellPurifiedβ-1,3-DglucanAnti-diabetesAnti-high-lipidsAnti-infectionafterhighriskoperationIncreaseofmarrowandwhitebloodcellsafterlethalradiationZymocellPurifiedβ-1,3-Dgluca17purity85%orhigherslightlybeigeveryfineparticulatefreefromproteinsandlipidsβ-Glucan

genuinepurity85%orhigherβ-Glucan18MechanismofUptakeParticulatesof2umindiametercouldbeeasilyengulfedbymacrophages.MechanismofUptakeParticulate19BetaGlucanEnhances

FourKeysImmuneResponsesProductionofwhitebloodcellsthatdestroypathogens.CellularmobilizationWBCtothesiteofaforeignchallenge.Phagocyticcapacityortheabilitytoengulfnon-selfcells.Productionofreactiveoxygenintermediatesandotheragentsthatkilltheforeigners.BetaGlucanEnhances

FourKey20BetaGlucanStimulates

Post-RadiationHematopoieticRecoveryinMiceBetaGlucanStimulates

Post-Ra21BetaGlucanStimulates

Post-RadiationHematopoieticRecoveryinMiceBetaGlucanStimulates

Post-Ra22

β-1,3-DglucanIncreasesPhagocyticCapacityofHumanInnateImmuneCellsβ-1,3-DglucanIncreasesPhag23多糖的分子量8kDa500kDa多糖的分子量8kDa500kDa24多糖的分枝度分支度在0.2～0.33抗腫瘤的效果最佳。多糖的分枝度分支度在252、企業(yè)團(tuán)(總)支部委員會(huì)對(duì)遞交入黨申請(qǐng)書(shū)一個(gè)月以上的團(tuán)員青年，在廣泛聽(tīng)取所在企業(yè)或崗位團(tuán)員、青年意見(jiàn)的基礎(chǔ)上，寫(xiě)出考察意見(jiàn)，并征得所在企業(yè)黨組織意見(jiàn)后，經(jīng)團(tuán)(總)支部委員會(huì)討論，確定為推優(yōu)對(duì)象，報(bào)上級(jí)團(tuán)委確認(rèn)后，填寫(xiě)《優(yōu)秀團(tuán)員、青年入黨積極分子推薦表》,由上級(jí)團(tuán)委向企業(yè)黨組織推薦；39.招標(biāo)人在簽署合同時(shí)更改數(shù)量的權(quán)利4.5及時(shí)完成領(lǐng)導(dǎo)交待的其他各項(xiàng)工作。40.招標(biāo)代理機(jī)構(gòu)接受或拒絕任何投標(biāo)的權(quán)力交款方式：磋商保證金可以以轉(zhuǎn)賬、支票、匯票、本票或者金融機(jī)構(gòu)出具的保函等非現(xiàn)金形式提交，所有遞交方式均以到帳時(shí)間為準(zhǔn)。在玩具城的賣(mài)場(chǎng)應(yīng)該避免設(shè)置桌子等物品。因?yàn)樽雷佑欣饨牵∨笥淹娴臅r(shí)候如果不注意就會(huì)碰得頭破血流。這樣，小孩子以后再也不會(huì)來(lái)，而且還告訴街坊鄰居和親朋好友不再來(lái)了。因此，安全性是玩具城服務(wù)規(guī)劃的重點(diǎn)，要提供安全的建筑和設(shè)備，尤其不能傷害到孩子。【自檢】發(fā)生下列情形時(shí)，在買(mǎi)方對(duì)賣(mài)方違約而采取的任何補(bǔ)救措施不受影響的情況下，用書(shū)面形式通知賣(mài)方，提出終止全部或部分合同。27.3本合同第27.1條款所列舉的任何文件，除了合同本身以外，均應(yīng)屬于是買(mǎi)方的財(cái)產(chǎn)。當(dāng)買(mǎi)方提出要求時(shí)，賣(mài)方在履行合同后應(yīng)將上述文件退還給買(mǎi)方。4.3掌握當(dāng)天的生產(chǎn)動(dòng)態(tài)、設(shè)備運(yùn)行情況，及時(shí)解決生產(chǎn)中的問(wèn)題。6、充裝檢查員崗位職責(zé)8.4.2對(duì)內(nèi)報(bào)表的增加與廢止BetaGlucaninaquaculture與體液因子及免疫細(xì)胞的特異受體結(jié)合15-30mg/kg體重或0.5-1g/kg飼料Infish促進(jìn)MФ向病灶轉(zhuǎn)移，ROS，抗病毒、抗應(yīng)激顯著提高疫苗效價(jià)InshellfishPO（酚氧化酶原系統(tǒng)）activity通過(guò)多種途徑參與機(jī)體的防御反應(yīng)2、企業(yè)團(tuán)(總)支部委員會(huì)對(duì)遞交入黨申請(qǐng)書(shū)一個(gè)月以上的團(tuán)員青26附：蝦蟹貝類(lèi)的免疫系統(tǒng)Hemocytesprophenoloxidase

→phenoloxidase,PO→氧化酪氨酸、二羥基苯丙氨酸等→生成苯醌中間產(chǎn)物→最終生成黑色素Oysterhemocyte附：蝦蟹貝類(lèi)的免疫系統(tǒng)HemocytesOysterhem27Peptidoglycan&LipopolysaccharidePeptidoglycan&Lipopolysaccha28PeptidoglycanPeptidoglycan29Mechanismsof

PeptidoglycanInvertebratesActivateT&BlymphocytesActivatephagocytesActivatecompletesystem通過(guò)血小板溶解釋放多種藥理活性物質(zhì)誘發(fā)抗體的產(chǎn)生和補(bǔ)體的生成MechanismsofPeptidoglycanIn30EffectsofPeptidoglycaninaquaculture混飼（6-60mg/kg體重或0.2-2g/kg飼料）降低條件致病菌感染引起的死亡率，預(yù)防病毒感染，防御寄生蟲(chóng)侵襲。與抗生素合用具有協(xié)同作用。作為疫苗的佐劑增強(qiáng)抗原細(xì)胞的信號(hào)分子被有效呈遞，促進(jìn)淋巴細(xì)胞產(chǎn)生抗體。促進(jìn)機(jī)體生長(zhǎng)，提高生長(zhǎng)率、存活率、飼料利用率。EffectsofPeptidoglycaninaq31EffectsofPeptidoglycaninFish從嗜熱雙歧桿菌（Bifidobacterium

thermophilum

）細(xì)胞壁中提取的肽聚糖，提高虹鱒（Oncorhynchus

mykiss）對(duì)弧菌病、五條鰤（Seriola

quinqueradiata）對(duì)鏈球菌病和日本對(duì)蝦（Penaeus

japonicus）對(duì)弧菌病與病毒性血癥的抵抗力。EffectsofPeptidoglycaninFi32EffectsofPeptidoglycaninShrimp促進(jìn)小顆粒細(xì)胞脫粒、抗菌肽的分泌激發(fā)細(xì)胞黏附、包囊作用促進(jìn)ROS生成提高透明細(xì)胞的吞噬功能激活絲氨酸蛋白酶原，激活酚氧化酶系統(tǒng)。EffectsofPeptidoglycaninSh33Lipopolysaccharide,LPS脂多糖Lipopolysaccharide,LPS脂多糖34MechanismsofLPS淋巴細(xì)胞有絲分裂原巨噬細(xì)胞激活劑，MФROS嗜菌作用刺激對(duì)蝦防御細(xì)胞的功能（嗜菌、黑色素沉著、包囊和凝結(jié)）注射0.01-0.05mg/kg體重混飼6-60mg/kg體重或0.2-2g/kg飼料MechanismsofLPS淋巴細(xì)胞有絲分裂原35LPS

ofA.stenohalisAchromobacterstenohalis,isolatedfromseawater.Inmouse,macrophages,B-lymphocytes,Anti-tumoreffectsInwhite-spottedcharInjectwithinactivatedA.stenohalisChemiluminescentresponsesofkidneycells,Complementactivation,ResistancetoA.salmonicidachallengeLPSofA.stenohalisAchromobac36Muramyldipeptide,MDP胞壁酰二肽，DerivedfromMycobacteriumIncohosalmon:injectionofMDP+modifiedFreund’sincompleteadjuvant，47-foldincreaseinresistancetoA.salmonicidaInrainbowtrout:injectionofMDP-LysPhagocyticactivities,respiratoryburstandmigrationactivitiesofkidneyleucocytes；ResistancetoA.salmonicida

Muramyldipeptide,MDP胞壁酰二肽，De37ChitinandChitosanChitinandChitosan383．三工并存、動(dòng)態(tài)轉(zhuǎn)換7、推薦優(yōu)秀團(tuán)干部至少在同級(jí)職務(wù)兩年以上。11.1本合同貨物按照本標(biāo)書(shū)第二章“前附表”中規(guī)定的以下第___種方式進(jìn)行驗(yàn)收：(五)理論考試。由領(lǐng)導(dǎo)小組辦公室組織競(jìng)崗人員參加理論知識(shí)、團(tuán)的業(yè)務(wù)知識(shí)和時(shí)事政治知識(shí)筆試，統(tǒng)一閱卷評(píng)分。筆試成績(jī)滿分為100分，占競(jìng)爭(zhēng)上崗總成績(jī)的30%。(13) 除本合同規(guī)定以外，業(yè)主方負(fù)責(zé)外部關(guān)系的協(xié)調(diào)。6.5對(duì)裸裝合同貨物應(yīng)以金屬標(biāo)簽注明上述內(nèi)容，裸裝合同貨物的裝箱單應(yīng)集中包裝，隨合同貨物發(fā)運(yùn)。【案例】9.4.2供應(yīng)商在采購(gòu)活動(dòng)中有違法、違紀(jì)行為的；7．衡量標(biāo)準(zhǔn)臺(tái)積電的企業(yè)文化可以概括為四個(gè)信條：堅(jiān)持高度的職業(yè)道德，維護(hù)企業(yè)機(jī)密，忠于職守，專(zhuān)注于積電制造服務(wù)本業(yè)。這四個(gè)信條的核心含義是：忠于顧客、忠于企業(yè)、忠于專(zhuān)業(yè)、忠于自我。2、 驗(yàn)收合格憑驗(yàn)收單及收款收據(jù)退還押金。2.9對(duì)容器的檢驗(yàn)（查）人員、操作人員進(jìn)行安全技術(shù)教育和技術(shù)考核工作。EffectsofchitinandchitosaninFishInjection,immersionororaladministrationChitinRainbowtroutPhagocyticactivity，ResistancetoVibrioanguillarum，yellowtailResistancetoP.piscicidaAdjuvanteffectsChitosan:de-N-acetylatedchitinRainbowtrout，NBT，myeloperoxidase，totalIgconcentrationbrooktroutResistancetoA.salmonicida3．三工并存、動(dòng)態(tài)轉(zhuǎn)換Effectsofchitina39適應(yīng)性免疫系統(tǒng)的主要成員B淋巴細(xì)胞與抗體輔助T淋巴細(xì)胞（Thcells)

與細(xì)胞因子（cytokines)細(xì)胞毒性T淋巴細(xì)胞（cytotoxicTcells,CTL)適應(yīng)性免疫系統(tǒng)的主要成員B淋巴細(xì)胞與抗體40激活的B細(xì)胞激活的CTL細(xì)胞APCsThcellsActivatedTh

B細(xì)胞CTL細(xì)胞PP激活的激活的APCsThcellsActivatedTh41EffectsoflevamisoleonfishSpleencells↑Phagocyticactivity↑NBTreaction↑Numberofantibody-producingcellsHighdoseNostimulationCompletelysuppressEffectsoflevamisoleonfish42PeptidoglycanPeptidoglycan43MechanismsofLPS淋巴細(xì)胞有絲分裂原巨噬細(xì)胞激活劑，MФROS嗜菌作用刺激對(duì)蝦防御細(xì)胞的功能（嗜菌、黑色素沉著、包囊和凝結(jié)）注射0.01-0.05mg/kg體重混飼6-60mg/kg體重或0.2-2g/kg飼料MechanismsofLPS淋巴細(xì)胞有絲分裂原44Muramyldipeptide,MDP胞壁酰二肽，DerivedfromMycobacteriumIncohosalmon:injectionofMDP+modifiedFreund’sincompleteadjuvant，47-foldincreaseinresistancetoA.salmonicidaInrainbowtrout:injectionofMDP-LysPhagocyticactivities,respiratoryburstandmigrationactivitiesofkidneyleucocytes；ResistancetoA.salmonicida

Muramyldipeptide,MDP胞壁酰二肽，De45適應(yīng)性免疫系統(tǒng)的主要成員B淋巴細(xì)胞與抗體輔助T淋巴細(xì)胞（Thcells)

與細(xì)胞因子（cytokines)細(xì)胞毒性T淋巴細(xì)胞（cytotoxicTcells,CTL)適應(yīng)性免疫系統(tǒng)的主要成員B淋巴細(xì)胞與抗體46PP感染的細(xì)胞PPP激活的補(bǔ)體系統(tǒng)自然殺傷細(xì)胞激活的NK巨噬細(xì)胞激活的MфMACMACC3bPP感染的細(xì)胞PPP激活的補(bǔ)體系統(tǒng)自然殺傷細(xì)胞激活的NK巨噬47激活的B細(xì)胞激活的CTL細(xì)胞APCsThcellsActivatedTh

B細(xì)胞CTL細(xì)胞PP激活的激活的APCsThcellsActivatedTh48Comparisonofcharacteristicsofchemotherapeutics,vaccinesandimmunostimulantsWhenEfficacySpectrumDurationtherapeuticallyprophylacticallyChemo-vaccineImmuno-Pro-excellentexcellentgoodmiddlelimitedwideshortshortlongComparisonofcharacteristics49免疫刺激劑ImmunostimunantsSyntheticchemicalsLevamisoleFK-565BiologicalsubstancesBacterialderivativesAnimalandplantextracts免疫刺激劑Immunostimunants50·HClLevamisoleAnthelminthicdrugInmammals↑metabolicandphagocyticactivitiesofneutrophils↑

numberofphagocytesandleucocytes↑leveloflsozymeinserum·HClLevamisoleAnthelminthicdr51InCohosalmonandCarpInjectionoflevamisole

+modifiedFreund’scompleteadjuvantincreasedCohosalmon’sresistancetoA.salmonicida.Injectionoflevamisoleincreasedthephagocyticactivityandmyeloperoxidaseactivityofneutrophils,leucocytenumbersandserumlysozymelevelsincarp.InCohosalmonandCarpInject52InRainbowtroutInjectionoflevamisole（0.1-0.5mg/kg）↑ResistancetoVibrioanguillarum↑Phagocyticactivityandchemiluminescanceresponsesofleucocytes↑NKcellactivities↑ConcentrationofcomplementNoeffectswithhighdose（5mg/kg）InRainbowtroutInjectionofl53EffectsoflevamisoleonfishSpleencells↑Phagocyticactivity↑NBTreaction↑Numberofantibody-producingcellsHighdoseNostimulationCompletelysuppressEffectsoflevamisoleonfish54Oraladministrationoflevamisole↑Leucocytenumbers↑Serumlysozymelevels↑ThestimulatedNBTreductionandphagocyticindexofphagocyticcellsOraladministrationoflevamis55ImmersionoflevamisoleCarpin10ug/mlfor24h↑ResistancetoA.hydrophila↑Chemotacticabilityofphagocytes↑PhagocyticactivityandchemiluminescenceRainbowtroutin5ug/mlfor30min↑Phagocyticactivityandindex↑Specificantibodytiters2minlaterinA.salmonicidaO-antigenbacterinImmersionoflevamisoleCarpin56FK-565FK-156Lactoyltetrapeptide,isolatedfromculturesofStreptomycesolivaceogriseus,isactiveagainstmicrobialinfectioninmice.FK-565isthesyntheticderivativeofFK-156.Heptanoyl-y-D-glutamyl-(L)-meso-diaminopimelyl-(D)-alanine，庚酮-谷氨酸-內(nèi)消旋-二氨基庚二基-丙氨酸FK-565FK-15657FK-565inRainbowtroutInjectionofFK-565↑ResistancetoA.salmonicida↑ActivationofphagocyticcellsInjectionofFK-565withY.ruckeriO-antigenorA.salmonicidaO-antigen↑Numberofsplenicantibody-producingcells↑SpecificantibodytitersFK-565inRainbowtroutInjecti58（4）投標(biāo)文件中的設(shè)備、技術(shù)參數(shù)明顯不符合招標(biāo)文件的要求；（3）如只是合同的一部分被終止，其他部分仍應(yīng)繼續(xù)執(zhí)行。a.通過(guò)科學(xué)的統(tǒng)計(jì)方法，說(shuō)明當(dāng)前的生產(chǎn)狀況、質(zhì)量水平，識(shí)別生產(chǎn)工藝質(zhì)量改進(jìn)重點(diǎn)，顯示過(guò)去的工作成效；②縣、區(qū)負(fù)責(zé)人的監(jiān)控，管理：（2）各地級(jí)市場(chǎng)部、人事部要培養(yǎng)后備干部，以備各個(gè)市場(chǎng)各級(jí)人員的被撤職、辭職人員進(jìn)行補(bǔ)充，后備干部要另外登記注冊(cè)，市場(chǎng)部對(duì)后備人員要重點(diǎn)培養(yǎng)。該類(lèi)窗口主要指地區(qū)、(往來(lái))單位類(lèi)別、商品類(lèi)別及會(huì)計(jì)科目等資料中要求進(jìn)行數(shù)據(jù)分級(jí)的編輯窗口。單擊左邊樹(shù)狀窗口中的類(lèi)別，然后就可以在右邊列表狀窗口中對(duì)該類(lèi)所屬的基礎(chǔ)資料進(jìn)行編輯操作。（3）由買(mǎi)方委托經(jīng)賣(mài)方認(rèn)可的法定質(zhì)量檢測(cè)機(jī)構(gòu)進(jìn)行驗(yàn)收，驗(yàn)收合格后由法定質(zhì)量檢測(cè)機(jī)構(gòu)出具驗(yàn)收?qǐng)?bào)告。驗(yàn)收費(fèi)用由買(mǎi)方承擔(dān)，另行支付。5.1.2統(tǒng)計(jì)方法選定的原則2.4充裝前要對(duì)瓶體進(jìn)行檢查，檢查外表面及其焊縫是否存在缺陷、閥座、塞座是否有裂紋、傾斜、塌陷等。(二)團(tuán)組織申報(bào)。擬進(jìn)行換屆的團(tuán)組織，向同級(jí)黨組織和上級(jí)團(tuán)委提出開(kāi)展競(jìng)爭(zhēng)上崗的申請(qǐng)，經(jīng)同意后按照領(lǐng)導(dǎo)小組辦公室的統(tǒng)一安排組織實(shí)施。4.6.2崗位職責(zé)范圍，應(yīng)知應(yīng)會(huì)；Polysaccharidesβ-glucanChitinChitosanOligosaccharideLentinanSchizophyllan（4）投標(biāo)文件中的設(shè)備、技術(shù)參數(shù)明顯不符合招標(biāo)文件的要求；P59Beta-1,3-DglucanBeta-1,3-Dglucan60Zymosan酵母聚糖Thenudecellwallofsaccharomycescerevisiae

1940'sDr.PillemerLouisAnti-tumoreffectinmouse

Proteins,lipidsandotherimpuritiesToxityandside-effectsZymosan酵母聚糖61ZymocellPurifiedβ-1,3-DglucanAnti-diabetesAnti-high-lipidsAnti-infectionafterhighriskoperationIncreaseofmarrowandwhitebloodcellsafterlethalradiationZymocellPurifiedβ-1,3-Dgluca62purity85%orhigherslightlybeigeveryfineparticulatefreefromproteinsandlipidsβ-Glucan

genuinepurity85%orhigherβ-Glucan63MechanismofUptakeParticulatesof2umindiametercouldbeeasilyengulfedbymacrophages.MechanismofUptakeParticulate64BetaGlucanEnhances

FourKeysImmuneResponsesProductionofwhitebloodcellsthatdestroypathogens.CellularmobilizationWBCtothesiteofaforeignchallenge.Phagocyticcapacityortheabilitytoengulfnon-selfcells.Productionofreactiveoxygenintermediatesandotheragentsthatkilltheforeigners.BetaGlucanEnhances

FourKey65BetaGlucanStimulates

Post-RadiationHematopoieticRecoveryinMiceBetaGlucanStimulates

Post-Ra66BetaGlucanStimulates

Post-RadiationHematopoieticRecoveryinMiceBetaGlucanStimulates

Post-Ra67

β-1,3-DglucanIncreasesPhagocyticCapacityofHumanInnateImmuneCellsβ-1,3-DglucanIncreasesPhag68多糖的分子量8kDa500kDa多糖的分子量8kDa500kDa69多糖的分枝度分支度在0.2～0.33抗腫瘤的效果最佳。多糖的分枝度分支度在702、企業(yè)團(tuán)(總)支部委員會(huì)對(duì)遞交入黨申請(qǐng)書(shū)一個(gè)月以上的團(tuán)員青年，在廣泛聽(tīng)取所在企業(yè)或崗位團(tuán)員、青年意見(jiàn)的基礎(chǔ)上，寫(xiě)出考察意見(jiàn)，并征得所在企業(yè)黨組織意見(jiàn)后，經(jīng)團(tuán)(總)支部委員會(huì)討論，確定為推優(yōu)對(duì)象，報(bào)上級(jí)團(tuán)委確認(rèn)后，填寫(xiě)《優(yōu)秀團(tuán)員、青年入黨積極分子推薦表》,由上級(jí)團(tuán)委向企業(yè)黨組織推薦；39.招標(biāo)人在簽署合同時(shí)更改數(shù)量的權(quán)利4.5及時(shí)完成領(lǐng)導(dǎo)交待的其他各項(xiàng)工作。40.招標(biāo)代理機(jī)構(gòu)接受或拒絕任何投標(biāo)的權(quán)力交款方式：磋商保證金可以以轉(zhuǎn)賬、支票、匯票、本票或者金融機(jī)構(gòu)出具的保函等非現(xiàn)金形式提交，所有遞交方式均以到帳時(shí)間為準(zhǔn)。在玩具城的賣(mài)場(chǎng)應(yīng)該避免設(shè)置桌子等物品。因?yàn)樽雷佑欣饨?，小朋友玩的時(shí)候如果不注意就會(huì)碰得頭破血流。這樣，小孩子以后再也不會(huì)來(lái)，而且還告訴街坊鄰居和親朋好友不再來(lái)了。因此，安全性是玩具城服務(wù)規(guī)劃的重點(diǎn)，要提供安全的建筑和設(shè)備，尤其不能傷害到孩子?！咀詸z】發(fā)生下列情形時(shí)，在買(mǎi)方對(duì)賣(mài)方違約而采取的任何補(bǔ)救措施不受影響的情況下，用書(shū)面形式通知賣(mài)方，提出終止全部或部分合同。27.3本合同第27.1條款所列舉的任何文件，除了合同本身以外，均應(yīng)屬于是買(mǎi)方的財(cái)產(chǎn)。當(dāng)買(mǎi)方提出要求時(shí)，賣(mài)方在履行合同后應(yīng)將上述文件退還給買(mǎi)方。4.3掌握當(dāng)天的生產(chǎn)動(dòng)態(tài)、設(shè)備運(yùn)行情況，及時(shí)解決生產(chǎn)中的問(wèn)題。6、充裝檢查員崗位職責(zé)8.4.2對(duì)內(nèi)報(bào)表的增加與廢止BetaGlucaninaquaculture與體液因子及免疫細(xì)胞的特異受體結(jié)合15-30mg/kg體重或0.5-1g/kg飼料Infish促進(jìn)MФ向病灶轉(zhuǎn)移，ROS，抗病毒、抗應(yīng)激顯著提高疫苗效價(jià)InshellfishPO（酚氧化酶原系統(tǒng)）activity通過(guò)多種途徑參與機(jī)體的防御反應(yīng)2、企業(yè)團(tuán)(總)支部委員會(huì)對(duì)遞交入黨申請(qǐng)書(shū)一個(gè)月以上的團(tuán)員青71附：蝦蟹貝類(lèi)的免疫系統(tǒng)Hemocytesprophenoloxidase

→phenoloxidase,PO→氧化酪氨酸、二羥基苯丙氨酸等→生成苯醌中間產(chǎn)物→最終生成黑色素Oysterhemocyte附：蝦蟹貝類(lèi)的免疫系統(tǒng)HemocytesOysterhem72Peptidoglycan&LipopolysaccharidePeptidoglycan&Lipopolysaccha73PeptidoglycanPeptidoglycan74Mechanismsof

PeptidoglycanInvertebratesActivateT&BlymphocytesActivatephagocytesActivatecompletesystem通過(guò)血小板溶解釋放多種藥理活性物質(zhì)誘發(fā)抗體的產(chǎn)生和補(bǔ)體的生成MechanismsofPeptidoglycanIn75EffectsofPeptidoglycaninaquaculture混飼（6-60mg/kg體重或0.2-2g/kg飼料）降低條件致病菌感染引起的死亡率，預(yù)防病毒感染，防御寄生蟲(chóng)侵襲。與抗生素合用具有協(xié)同作用。作為疫苗的佐劑增強(qiáng)抗原細(xì)胞的信號(hào)分子被有效呈遞，促進(jìn)淋巴細(xì)胞產(chǎn)生抗體。促進(jìn)機(jī)體生長(zhǎng)，提高生長(zhǎng)率、存活率、飼料利用率。EffectsofPeptidoglycaninaq76EffectsofPeptidoglycaninFish從嗜熱雙歧桿菌（Bifidobacterium

thermophilum

）細(xì)胞壁中提取的肽聚糖，提高虹鱒（Oncorhynchus

mykiss）對(duì)弧菌病、五條鰤（Seriola

quinqueradiata）對(duì)鏈球菌病和日本對(duì)蝦（Penaeus

japonicus）對(duì)弧菌病與病毒性血癥的抵抗力。EffectsofPeptidoglycaninFi77EffectsofPeptidoglycaninShrimp促進(jìn)小顆粒細(xì)胞脫粒、抗菌肽的分泌激發(fā)細(xì)胞黏附、包囊作用促進(jìn)ROS生成提高透明細(xì)胞的吞噬功能激活絲氨酸蛋白酶原，激活酚氧化酶系統(tǒng)。EffectsofPeptidoglycaninSh78Lipopolysaccharide,LPS脂多糖Lipopolysaccharide,LPS脂多糖79MechanismsofLPS淋巴細(xì)胞有絲分裂原巨噬細(xì)胞激活劑，MФROS嗜菌作用刺激對(duì)蝦防御細(xì)胞的功能（嗜菌、黑色素沉著、包囊和凝結(jié)）注射0.01-0.05mg/kg體重混飼6-60mg/kg體重或0.2-2g/kg飼料MechanismsofLPS淋巴細(xì)胞有絲分裂原80LPS

ofA.stenohalisAchromobacterstenohalis,isolatedfromseawater.Inmouse,macrophages,B-lymphocytes,Anti-tumoreffectsInwhite-spottedcharInjectwithinactivatedA.stenohalisChemiluminescentresponsesofkidneycells,Complementactivation,ResistancetoA.salmonicidachallengeLPSofA.stenohalisAchromobac81Muramyldipeptide,MDP胞壁酰二肽，DerivedfromMycobacteriumIncohosalmon:injectionofMDP+modifiedFreund’sincompleteadjuvant，47-foldincreaseinresistancetoA.salmonicidaInrainbowtrout:injectionofMDP-LysPhagocyticactivities,respiratoryburstandmigrationactivitiesofkidneyleucocytes；Re