Epetraborole-GSK-2251052-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEEpetraboroleCat.No.:HY-12479CASNo.:1093643-37-8Synonyms:GSK-2251052;AN3365分子式:C??H??BNO?分子量:237.06作用靶點(diǎn):Bacterial;Aminoacyl-tRNASynthetase作用通路:Anti-infection;MetabolicEnzyme/Protease儲(chǔ)存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Epetraborole(GSK2251052)是一種亮氨酰-tRNA合成酶(LeuRS)抑制劑(IC50=0.31μM)，從而抑制蛋白質(zhì)的合成。Epetraborole可用于耐多藥的革蘭氏陰性病原體感染的研究。IC50&TargetIC50:0.31μM(LeuRS)[3]體外研究Epetraborole(0-32μg/mL)showsanti-bacterialactivityagainstkeygram-negativeaerobicandanaerobicpathogensandgram-positiveanaerobes[1].CellViabilityAssay[1]CellLine:AnaerobesisolatesConcentration:0-32μg/mLIncubationTime:Result:ShowedMIC50/MIC90forallanaerobesisolatestestedof2and4μg/mL,respectively.客戶使用本產(chǎn)品發(fā)表的科研文獻(xiàn)AntimicrobAgentsChemother.2023Jan23;e0145922.AntimicrobAgentsChemother.2021Jul19;AAC0115621.1/2 MasterofBioactiveMolecules—您身邊的抑制劑大師www.MedChemESeemorecustomervalidationsonwww.MedChemEREFERENCESGoldsteinEJ,etal.ComparativeinvitroactivitiesofGSK2251052,anovelboron-containingleucyl-tRNAsynthetaseinhibitor,against916anaerobicorganisms.AntimicrobAgentsChemother.2013May;57(5):2401-4.O'DwyerK,etal.Bacterialresistancetoleucyl-tRNAsynthetaseinhibitorGSK2251052developsduringtreatmentofcomplicatedurinarytractinfections.AntimicrobAgentsChemother.2015Jan;59(1):289-98.SutcliffeJA.Antibioticsindevelopmenttargetingproteinsynthesis.AnnNYAcadSci.2011Dec;1241:122-52.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-5