Triclosan-13C12-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemETriclosan-13C12Cat.No.:HY-W747491CASNo.:1365620-36-5分子式:??C??H?Cl?O?分子量:301.45作用靶點(diǎn):Isotope-LabeledCompounds;Antibiotic;Apoptosis;Bacterial;Fungal作用通路:Others;Anti-infection;Apoptosis儲(chǔ)存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性 Triclosan-13C12是13C標(biāo)記的Triclosan。Triclosan是一種廣譜抗菌劑，可抑制細(xì)菌脂肪酸在烯?；d體蛋白還原酶(FabI)階段的合成。Triclosan抑制大腸桿菌烯酰?；d體蛋白還原酶(FabI)和第93位含有甘氨酸至纈氨酸取代的FabI(FabIG93V)，IC50分別為2μM和10μM。Triclosan可導(dǎo)致培養(yǎng)的大鼠神經(jīng)干細(xì)胞(NSC)細(xì)胞凋亡。Triclosan會(huì)加劇動(dòng)物模型中結(jié)腸炎和結(jié)腸炎相關(guān)的結(jié)直腸腫瘤的發(fā)生。REFERENCESRussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019Feb;53(2):211-216.JiananZhang,etal.Microbialenzymesinducecolitisbyreactivatingtriclosaninthemousegastrointestinaltract.NatCommun.2022Jan10;13(1):136.RJHeath,etal.Mechanismoftriclosaninhibitionofbacterialfattyacidsynthesis.JBiolChem.1999Apr16;274(16):11110-4.BoKyungPark,etal.EffectsofTriclosanonNeuralStemCellViabilityandSurvival.BiomolTher(Seoul).2016Jan;24(1):99-107.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax:021-53700