9R-RO7185876-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemE(9R)-RO7185876Cat.No.:HY-145343ACASNo.:2226077-86-5分?式:C??H??F?N?分?量:483.53作?靶點:γ-secretase;Amyloid-β作?通路:NeuronalSignaling;StemCell/Wnt儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性數(shù)據(jù)體外實驗DMSO:100mg/mL(206.81mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.0681mL10.3406mL20.6812mL5mM0.4136mL2.0681mL4.1362mL10mM0.2068mL1.0341mL2.0681mL體內(nèi)實驗請根據(jù)您的實驗動物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結(jié)果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實驗的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥5mg/mL(10.34mM);ClearsolutionBIOLOGICALACTIVITY?物活性(9R)-RO7185876(Compoundexample16)?種γ-secretase抑制劑。(9R)-RO7185876抑制Αβ42的分泌。(9R)-RO7185876可?于阿爾茨海默病、腦淀粉樣變性?管病、遺傳性腦出?伴淀粉樣變性、多梗塞性癡呆1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE、?年性癡呆或唐?綜合征的研究[1]。REFERENCES[1].BjoernBartels,etal.Bicyclicheteroarylderivatives.WO2018083050.WIPO.2018-05-11.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021-537003