RFRP-3-mouse-Neuropeptide-NPVF-mouse-生命科學試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemERFRP-3(mouse)Cat.No.:HY-P10780Synonyms:NeuropeptideNPVF(mouse)分?式:C??H???N??O??S分?量:2073.34Sequence:Val-Asn-Met-Glu-Ala-Gly-Thr-Arg-Ser-His-Phe-Pro-Ser-Leu-Pro-Gln-Arg-Phe-NH2SequenceShortening:VNMEAGTRSHFPSLPQRF-NH2作?靶點:NeuropeptideFFReceptor;Apoptosis;MDM-2/p53;PERK作?通路:GPCR/GProtein;Apoptosis;CellCycle/DNADamage儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性RFRP-3(mouse)禽類促性腺激素抑制激素(GnIH)的功能同物，與GPR147結(jié)合。RFRP-3(mouse)通過抑制FSHR和參與類醇?成的關(guān)鍵酶(P450scc、3β-HSD、StAR)來減少Progesterone的合成。RFRP-3(mouse)誘導(dǎo)細胞凋亡(Apoptosis)(p53增加)。RFRP-3(mouse)還能抑制ERK信號通路。RFRP-3可?于泡發(fā)育研究[1]。體外研究RFRP-3(mouse)(10-1000ng/mL,24h)significantlyreducesProgesteronesecretionbutnotEstradiolsecretionintheovariangranulosacellsofmice[1].RFRP-3(mouse)(10-1000ng/mL,24h)inhibitssteroidogenesisandFSHR(inhibitionofp450scc,3β-HSD,StAR,andFSHR)intheovariangranulosacellsofmice[1].RFRP-3(mouse)(10-1000ng/mL,24h)inducesapoptosis,withloweringBcl-2proteinexpressionandincreasingp53proteinexpressionatthemediumdose[1].RFRP-3(mouse)(10-1000ng/mL,24h)suppressesERKsignalingpathway(p-ERK1/2protein)intheovariangranulosacellsofmice[1].RealTimeqPCR[1]CellLine:GranulosacellsConcentration:10,100,1000ng/mL1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEIncubationTime:24hResult:Reducedp450sccmRNAexpressionat100ng/mL,butdidnotsignificantlyalterp450sccexpressionatlowdose(10ng/mL)andhighdose(1000ng/mL).Reduced3β-HSD,FSHRandStARexpressionat100ng/mLand1000ng/mL,whereashadnosignificanteffectat10ng/mL.REFERENCES[1].GuoX,etal.Rfamide-relatedpeptide-3(RFRP-3)receptorgeneisexpressedinmouseovariangranulosacells:PotentialroleofRFRP-3insteroidogenesisandapoptosis.Steroids.2024Feb;202:109349.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:4