




版權(quán)說明:本文檔由用戶提供并上傳,收益歸屬內(nèi)容提供方,若內(nèi)容存在侵權(quán),請進行舉報或認領(lǐng)
文檔簡介
1、基于微膠囊的光學(xué)生物傳感器Microcapsules as optical biosensorsIntroductioncolor-changing particles reside primarily in the dermisrespond to changes in interstitial fluid compositionmeasurable shifts in their optical properties.external optical device pass light into the skincollectreflected or emitted lightperfor
2、m analysis to report interstitial composition to the patient in a continuous or spot fashionsmart tattooExamples of this concept : fluorescent microspheres/capsules, hollow fiber membranes encapsulating sensing chemistry, and polymeric slabs doped with fluorescent reagents.the target species are abl
3、e to freely diffuse into the container, while permanently compartmentalizing the sensing reagentsThe key to making this approach viable:engineer implantable materials, sensitivity, operational stability, and biocompatibility for long-term useEncapsulation within polyelectrolyte multilayer capsules N
4、ano-engineered microcapsule carriers is an effective means of encapsulating sensing reagents.Different approaches to entrap optical sensing assays: various types of microvesicles, including liposomes, polymersomes, and polyelectrolyte microcapsules. Polyelectrolyte microcapsules are formed by deposi
5、ting alternating layers of charged polymers onto sacrificial templates using the layer-by-layer (LbL) nanoscale self assembly process, which is followed by the removal of the template via chemical treatment.layer-by-layer (LbL) nanoscale self-assembly process allows for an even wider assortment of c
6、andidate materials.The goal of encapsulation is to trap the sensing reagents behind a semi-permeable Barrier.The sensor chemistry must be trapped in sufficient quantity for the optical response to be measured.Three principal methods:Precipitation, adsorption/absorption, diffusion1. Diffusion2. adsor
7、ption/absorptionAdvantage: virtually any removable template can be usedDisadvantages: low loading efficiency, requirement to use materials that can be induced to alter pore size, effects encapsulated speciesAdvantage: allows use of any polymers amenable to the LbL assembly methodDisadvantages: loss
8、of adsorbed/absorbed molecules during the LbL processExamples: PLL/PGA multilayer films on mesoporous silica (MS) spheres 3. PrecipitationAdvantage: high loading efficiencies, minimal concern over denaturation or other damage to sensing reagents, entrapped molecules remain stably entrapped during th
9、e LbL processDisadvantages: prepare templates each time encapsulation is performed, size distribution of coprecipitated particles is changed, large amounts of sensing reagents used in the coprecipitation process.Biosensors using PEM capsulesExamples: nano-engineered glucose sensor microcapsules base
10、d on glucose/galactose-binding proteinDifficult challenges Further work1 Mike McShane, Dustin Ritter, “Microcapsules as optical biosensors, Journal of Materials Chemistry, 20(2021)818981932 Aimin Yu, Ian R. Gentle, Gao Qing (Max) Lu, “Biocompatible polypeptide microcapsules via templating mesoporous
11、 silica spheres, Journal of Colloid and Interface Science 333 (2021) 341343 Tania Saxla, Faaizah Khan, Daniel R. Matthews, Zheng-Liang Zhi,Olaf Rolinski, Simon Ameer-Beg, John Pickup, “Fluorescence lifetime spectroscopy and imaging of nano-engineered glucose sensor microcapsules based on glucose/galactose-binding protein, Biosensors and Bioelectronics,
溫馨提示
- 1. 本站所有資源如無特殊說明,都需要本地電腦安裝OFFICE2007和PDF閱讀器。圖紙軟件為CAD,CAXA,PROE,UG,SolidWorks等.壓縮文件請下載最新的WinRAR軟件解壓。
- 2. 本站的文檔不包含任何第三方提供的附件圖紙等,如果需要附件,請聯(lián)系上傳者。文件的所有權(quán)益歸上傳用戶所有。
- 3. 本站RAR壓縮包中若帶圖紙,網(wǎng)頁內(nèi)容里面會有圖紙預(yù)覽,若沒有圖紙預(yù)覽就沒有圖紙。
- 4. 未經(jīng)權(quán)益所有人同意不得將文件中的內(nèi)容挪作商業(yè)或盈利用途。
- 5. 人人文庫網(wǎng)僅提供信息存儲空間,僅對用戶上傳內(nèi)容的表現(xiàn)方式做保護處理,對用戶上傳分享的文檔內(nèi)容本身不做任何修改或編輯,并不能對任何下載內(nèi)容負責。
- 6. 下載文件中如有侵權(quán)或不適當內(nèi)容,請與我們聯(lián)系,我們立即糾正。
- 7. 本站不保證下載資源的準確性、安全性和完整性, 同時也不承擔用戶因使用這些下載資源對自己和他人造成任何形式的傷害或損失。
最新文檔
- 影視設(shè)備智能穿戴設(shè)備集成考核試卷
- 石墨在微波吸收材料的研究考核試卷
- 森林保護與青少年素質(zhì)教育考核試卷
- 生活的苦與樂初三語文作文
- 朋友初三語文作文
- 河南省洛陽市老城區(qū)三校聯(lián)考2023-2024學(xué)年八年級下學(xué)期7月期末考試數(shù)學(xué)試卷(含答案)
- 橋梁施工技術(shù)與質(zhì)量控制考核試卷
- 紙質(zhì)航空航天材料研發(fā)與性能評價考核試卷
- 玩具企業(yè)的產(chǎn)品線拓展與市場定位考核試卷
- 等離子體刻蝕設(shè)備的安全控制考核試卷
- 比例尺單元測試卷及答案
- 北京市朝陽區(qū)2025屆高三下學(xué)期一模試題 數(shù)學(xué) 含答案
- 食品工廠5S管理
- 運輸公司安全管理制度
- 2025屆吉林省長春市高三下學(xué)期4月三模政治試題(原卷版+解析版)
- 2025屆江蘇省揚州市中考一模語文試題(含答案)
- 2025年河北省唐山市中考一模道德與法治試題(含答案)
- 2025年一級注冊計量師考試題庫大全及答案
- 衛(wèi)生院全國預(yù)防接種日宣傳活動總結(jié)(8篇)
- 2024國家電投集團中國電力招聘(22人)筆試參考題庫附帶答案詳解
- 大數(shù)據(jù)在展覽中的應(yīng)用-全面剖析
評論
0/150
提交評論