Decursin-plus-Decursin-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDecursinCat. No.: HY-18981CAS No.: 5928-25-6Synonyms: (+)-Decursin分式: CHO分量: 328.36作靶點(diǎn): Others作通路: Others儲(chǔ)存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 125 mg/mL (380.

2、68 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.0454 mL 15.2272 mL 30.4544 mL5 mM 0.6091 mL 3.0454 mL 6.0909 mL10 mM 0.3045 mL 1.5227 mL 3.0454 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄

3、清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (6.33 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (6.33 mM); Clear solution3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 m

4、g/mL (6.33 mM); Clear solution; Need warming1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Decursin種抗癌物質(zhì)，并具有潛在的抗炎活性。體外研究 Decursin (25-100 M) shows a strong dose- and time-dependent inhibition of cell growth, accounting for 22%to 51%, 21% to 68%, 9% to 72%, and 42% to 90% gro

5、wth inhibition after 24, 48, 72, and 96 hours oftreatment, respectively. Furthermore, it is observed that both Decursin and Decursinol have cytotoxic effecton DU145 cells, in which similar treatment (25-100 M for 24, 48, 72, and 96 hours) with Decursin cause15% to 45% cell death versus 11% to 12% in

6、 controls 1. Decursin blocks tumor progression by suppressionof angiopoietin-2, angiopoietin receptor Tie-2, and endothelial nitric oxide synthase (eNOS) in endothelialprogenitor cells. Decursin has the ability to inhibit vascular endothelial growth factor (VEGF)-inducedproliferation, metastasis, an

7、d tube formation in human umbilical vein endothelial cells (HUVECs). Decursininhibits pro-inflammatory molecules, such as chemokines, cytokines, and enzymes such as Cyclooxygenase-2 (COX-2) and MMPs 2.PROTOCOLCell Assay 1 To assess the biological activity of these compounds in terms of cell growth a

8、nd death, DU145 cells aretreated with 25, 50, and 100 M doses of Decursin and Decursinol for 24, 48, 72, and 96 hours 1.MCE has not independently confirmed the accuracy of these methods. They are for reference only.REFERENCES1. Yim D, et al. A novel anticancer agent, decursin, induces G1 arrest and

9、apoptosis in human prostate carcinoma cells. Cancer Res. 2005Feb 1;65(3):1035-44.2. Shehzad A, et al. Decursin and decursinol angelate: molecular mechanism and therapeutic potential in inflammatory diseases. InflammRes. 2018 Mar;67(3):209-218.McePdfHeightCaution: Product has not been fully validated for medical