Imiquimod-R-837-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEImiquimodCat. No.: HY-B0180CAS No.: 99011-02-6Synonyms: R 837分式: CHN分量: 240.3作靶點(diǎn): Toll-like Receptor (TLR); Autophagy作通路: Immunology/Inflammation; Autophagy儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解

2、性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 2.5 mg/mL (10.40 mM; Need ultrasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 4.1615 mL 20.8073 mL 41.6146 mL5 mM 0.8323 mL 4.1615 mL 8.3229 mL10 mM 0.4161 mL 2.0807 mL 4.1615 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Imiquimod (R 837)種

3、免疫反應(yīng)調(diào)節(jié)劑，作為 toll-like receptor 7 的激動(dòng)劑起作。IC50 & Target toll-like receptor 7 1體內(nèi)研究In animal models, imiquimod stimulates the innate immune response by increasing NK cell activity, activatingmacrophages to secretecytokines and nitric oxide, and inducing proliferation and differentiation of B1/2 Master o

4、f Small Molecules 您邊的抑制劑師www.MedChemElymphocytes. Imiquimod stimulates the innate immune response through induction, synthesis, and release ofcytokines, including interferon-a (IFN-), interleukin (IL)-6, and tumour necrosis factor (TNF)- 1.戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Nat Commun. 2016 May 25;7:11724. Biomaterials. 2019 Jan.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Bilu D, et al. Imiquimod: modes of action. Br J Dermatol. 2003 Nov;149 Suppl 66:5-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-589559