Mofegiline-hydrochloride-MDL72974A-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMofegiline hydrochlorideCat. No.: HY-16677ACAS No.: 120635-25-8Synonyms: MDL72974A分式: CHClFN分量: 233.69作靶點: Monoamine Oxidase作通路: Neuronal Signaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 H

2、2O : 39 mg/mL (166.89 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 4.2792 mL 21.3959 mL 42.7917 mL5 mM 0.8558 mL 4.2792 mL 8.5583 mL10 mM 0.4279 mL 2.1396 mL 4.2792 mL請根據(jù)產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Mofegiline hydroc

3、hloride (MDL72974A)是酶活化的不可逆MAO-B抑制劑，對MAO-A和MAO-B的IC50分別為680和3.6 nM。REFERENCES1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE1. Zreika M, et al. MDL 72,974: a potent and selective enzyme-activated irreversible inhibitor of monoamine oxidase type B with potentialfor use in Parkinsons disease. J Neur

4、al Transm Park Dis Dement Sect. 1989;1(4):243-54.2. Yu PH, et al. Inhibition of a type B monoamine oxidase inhibitor, (E)-2-(4-fluorophenethyl)-3-fluoroallylamine (MDL-72974A), onsemicarbazide-sensitive amine oxidases isolated from vascular tissues and sera of different species. Biochem Pharmacol. 1

5、992 Jan22;43(2):307-12.3. Dow J, et al. Novel carbamate metabolites of mofegiline, a primary amine monoamine oxidase B inhibitor, in dogs and humans. DrugMetab Dispos. 1994 Sep-Oct;22(5):738-49.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-5895