Vipivotide-tetraxetan-Linker-PSMA-617-Linker-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEVipivotide tetraxetan LinkerCat. No.: HY-43869CAS No.: 1703768-74-4Synonyms: PSMA-617 Linker分式: CHNO分量: 655.74作靶點: PROTAC Linker; ADC Linker作通路: PROTAC; Antibody-drug Conjugate/ADC Related儲存式: Powder -80C 2 years-20C 1 yearIn so

2、lvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 270 mg/mL (411.75 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 1.5250 mL 7.6250 mL 15.2499 mL5 mM 0.3050 mL 1.5250 mL 3.0500 mL10 mM 0.1525 mL 0.7625 mL 1.5250 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內實驗請根據(jù)您的實驗動物和給藥式選擇適

3、當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結果的可靠性，體內實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.25 mg/mL (3.43 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.25 mg/mL (3.43 mM); Clear

4、solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.25 mg/mL (3.43 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Vipivotide tetraxetan Linker種有效的肽類接頭，可于合成 Vipivotide tetraxetan (PSMA-617)。Vipivotide tetraxetan (PSMA-617) 于合成 177Lu-PSMA-617 的配體，177Lu-

5、PSMA-617 于治療前列腺癌的種放射性分 1。IC50 & Target Alkyl-ChainREFERENCES1. Beneov M, et al. Albumin-Binding PSMA Ligands: Optimization of the Tissue Distribution Profile. Mol Pharm. 2018 Mar 5;15(3):934-946.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-5895