BAY-1895344-hydrochloride-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBAY-1895344 hydrochlorideCat. No.: HY-101566A分式: CHClNO分量: 411.89作靶點(diǎn): ATM/ATR作通路: Cell Cycle/DNA Damage; PI3K/Akt/mTOR儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 54 mg/mL (131.10 mM; Ne

2、ed ultrasonic and warming)H2O : 50 mg/mL (121.39 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.4278 mL 12.1392 mL 24.2783 mL5 mM 0.4856 mL 2.4278 mL 4.8557 mL10 mM 0.2428 mL 1.2139 mL 2.4278 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 BAY-1895344 h

3、ydrochloride種有效、可服、選擇性的 ATR 抑制劑，IC50 值為 7 nM。具有抗腫瘤活性1。IC50 & Target ATR7 nM (IC50)體外研究BAY-1895344 potently inhibits the proliferation of a broad spectrum of human tumor cell lines with a medianIC50 of 78 nM 1.1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBAY-1895344 potently suppresses hydroxyure

4、a-induced H2AX phosphorylation (IC50, 36 nM) 1.體內(nèi)研究 BAY-1895344 shows potent anti-tumor efficacy in monotherapy in a variety of xenograft models of ovarianand colorectal cancer, and causes complete tumor remission in mantle cell lymphoma models 2.REFERENCES1. Ulrich T. Luecking, et al. Abstract 983:

5、 Identification of potent, highly selective and orally available ATR inhibitor BAY 1895344 withfavorable PK properties and promising efficacy in monotherapy and combination in preclinical tumor models. Cancer Research. July 2017Volume 77, Issue 13 Supplement.2. Antje Margret Wengner, et al. Abstract

6、 836: ATR inhibitor BAY 1895344 shows potent anti-tumor efficacy in monotherapy and strongcombination potential with the targeted alpha therapy Radium-223 dichloride in preclinical tumor models. Cancer Research. July 2017Volume 77, Issue 13 SupplementMcePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-