SBFI-26-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESBFI-26Cat. No.: HY-117506BCAS No.: 1541207-06-0分式: CHO分量: 422.47作靶點(diǎn): FABP作通路: Metabolic Enzyme/Protease儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 100 mg/mL (236.70 mM; Need ultrasonic

2、)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.3670 mL 11.8352 mL 23.6703 mL5 mM 0.4734 mL 2.3670 mL 4.7341 mL10 mM 0.2367 mL 1.1835 mL 2.3670 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前

3、的百分指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.92 mM); Clear solutionBIOLOGICAL ACTIVITY物活性SBFI-26種選擇性和競(jìng)爭(zhēng)性的脂酸結(jié)合蛋 FABP5 和 FABP7 抑制劑， 對(duì) FABP5 和 FABP7 作的 Ki 值1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE分別為 0.9 M 和 0.4 M。SBFI-26 具有抗傷害性和抗炎作 1 2。IC50 & Target Ki: 0.9

4、 M (FABP5), 0.4 M (FABP7) 1 2體外研究 SBFI-26 binds to the canonical ligand-binding pocket of FABP5 1.SBFI-26 significantly inhibits cellular AEA accumulation 2.體內(nèi)研究 SBFI-26 (20 mg/kg, i.p.) significantly reduces carrageenan-induced thermal hyperalgesia and paw edema 2.SBFI-26 produces antinociceptive a

5、nd anti-inflammatory effects in mice 2.Animal Model: Mice 2Dosage: 20 mg/kgAdministration: Intraperitoneal injectionResult: Significantly reduced carrageenan-induced thermal hyperalgesia and paw edema.REFERENCES1. Berger WT, et al. Targeting fatty acid binding protein (FABP) anandamide transporters

6、- a novel strategy for development of anti-inflammatory and anti-nociceptive drugs. PLoS One. 2012;7(12):e50968.2. Hsu HC, et al. The Antinociceptive Agent SBFI-26 Binds to Anandamide Transporters FABP5 and FABP7 at Two Different Sites.Biochemistry. 2017 Jul 11;56(27):3454-3462.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400