Bendazac-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBendazacCat. No.: HY-17480CAS No.: 20187-55-7分式: CHNO分量: 282.29作靶點(diǎn): Others作通路: Others儲(chǔ)存式: Please store the product under the recommended conditions inthe COA.溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 250 mg/mL (885.61 mM; Need ultrasonic)Mass Solvent1 m

2、g 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.5425 mL 17.7123 mL 35.4246 mL5 mM 0.7085 mL 3.5425 mL 7.0849 mL10 mM 0.3542 mL 1.7712 mL 3.5425 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分指該溶劑在您配制終溶液中的

3、體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (7.37 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (7.37 mM); Clear solutionBIOLOGICAL ACTIVITY物活性Bendazac種氧酸，具有抗炎、抗過(guò)敏、利膽和抗脂的特性。Bendazac 阻蛋質(zhì)變性，延緩內(nèi)障1/2 Master of Small Molecules 您邊的抑制劑師

4、www.MedChemE的發(fā)過(guò)程。體外研究 Bendazac is an anti-inflammatory agent endowed with protein antidenaturant properties effective for variousinflammatory skin conditions. Bendazac has been shown to be a strong reacting substrate in a chemicaloxidizing system, which mimics a physiological pathway of hydroxy radi

5、cal generation 2.By using EPR spectroscopy of spin-labelled bovine serum albumin (BSA), Bendazac was shown to preventthe BSA denaturation induced by urea, heat and free radicals produced in the xanthine/xanthine oxidasesystem 2.REFERENCES1. Balfour JA, et al. Bendazac lysine. A review of its pharmac

6、ological properties and therapeutic potential in the management of cataracts.Drugs. 1990;39(4):575-596.2. Guglielmotti A, et al. Radical scavenger activity of bendazac, an anticataract non-steroidal anti-inflammatory agent. Pharmacol Res.1995;32(6):369-373.3. Musci G, et al. Mechanism of the scavenger-like activity of bendazac. Drugs Exp Clin Res. 1987;13(5):289-292.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel