Flavokawain-A-DataSheet-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemEFlavokawainACat.No.:HY-N2420CASNo.:3420-72-2分?式:C??H??O?分?量:314.33作?靶點:Apoptosis作?通路:Apoptosis儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:100mg/mL(318.14mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM3.1814mL15.9069mL31.8137mL5mM0.6363mL3.1814mL6.3627mL10mM0.3181mL1.5907mL3.1814mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存?式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥?式選擇適當?shù)娜芙?案，配制前請先配制澄的儲備液，再依次添加助溶劑(為保證實驗結(jié)果的可靠性，體內(nèi)實驗的?作液，建議您現(xiàn)?現(xiàn)配，當天使?；澄的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分?指該溶劑在您配制終溶液中的體積占?)：1.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(7.95mM);ClearsolutionBIOLOGICALACTIVITY?物活性FlavokawainA?種抗癌試劑(anticarcinogenicagent)，kava提取物中的查?酮，具有抗腫瘤活性。1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemEFlavokawainA通過Bax蛋?依賴和線粒體依賴的凋亡途徑誘導細胞凋亡(apoptosis)。FlavokawainA有潛??于膀胱癌的相關(guān)研究。REFERENCES[1].XiaolinZi,etal.FlavokawainA,anovelchalconefromkavaextract,inducesapoptosisinbladdercancercellsbyinvolvementofBaxprotein-dependentandmitochondria-dependentapoptoticpathwayandsuppressestumorgrowthinmice.CancerRes.2005Apr15;65(8):3479-86.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021