Ochromycinone-Rac-STA-21-DataSheet-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemEOchromycinoneCat.No.:HY-18061CASNo.:111540-00-2Synonyms:(Rac)-STA-21分?式:C??H??O?分?量:306.31作?靶點:STAT;Bacterial作?通路:JAK/STATSignaling;StemCell/Wnt;Anti-infection儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:16.67mg/mL(54.42mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM3.2647mL16.3233mL32.6467mL5mM0.6529mL3.2647mL6.5293mL10mM0.3265mL1.6323mL3.2647mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存?式和期限。體內實驗請根據(jù)您的實驗動物和給藥?式選擇適當?shù)娜芙?案，配制前請先配制澄的儲備液，再依次添加助溶劑(為保證實驗結果的可靠性，體內實驗的?作液，建議您現(xiàn)?現(xiàn)配，當天使?；澄的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分?指該溶劑在您配制終溶液中的體積占?)：1.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥1.67mg/mL(5.45mM);ClearsolutionBIOLOGICALACTIVITY1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemE?物活性Ochromycinone((Rac)-STA-21)?種天然抗?素，也?種STAT3抑制劑。Ochromycinone可抑制STAT3DNA結合活性，STAT3?聚化。Ochromycinone具有抗癌和抗活性。IC50&TargetSTAT3體外研究STA-21inhibitsSTAT3DNAbindingactivity,STAT3dimerization,andSTAT3-dependentluciferaseactivity.Moreover,STA-21reducesthesurvivalofbreastcarcinomacellswithconstitutiveSTAT3signalingbuthasminimaleffectonthecellsinwhichconstitutiveSTAT3signalingisabsent[2].REFERENCES[1].SongH,etal.Alow-molecular-weightcompounddiscoveredthroughvirtualdatabasescreeninginhibitsStat3functioninbreastcancercells.ProcNatlAcadSciUSA.2005Mar29;102(13):4700-5.[2].NataliyaI.Kalinovskaya,etal.NewAngucyclinonesfromtheMarineMolluskAssociatedActinomyceteSaccharothrixespanaensisAn113.Naturalproductcommunications.2008,?3(10):1611-1616.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792