Adrenochrome-Adraxone-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEAdrenochromeCat.No.:HY-116513CASNo.:54-06-8Synonyms:Adraxone分?式:C?H?NO?分?量:179.17作?靶點:Others作?通路:Others儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性數(shù)據(jù)體外實驗DMSO:100mg/mL(558.13mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM5.5813mL27.9065mL55.8129mL5mM1.1163mL5.5813mL11.1626mL10mM0.5581mL2.7906mL5.5813mL體內(nèi)實驗請根據(jù)您的實驗動物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結(jié)果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實驗的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:2.5mg/mL(13.95mM);Suspendedsolution;Needultrasonic2.請依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:2.5mg/mL(13.95mM);Suspendedsolution;NeedultrasonicBIOLOGICALACTIVITY1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE?物活性Adrenochrome(Adraxone)Epinephrine的氧化產(chǎn)物。Adrenochrome???臟中?種有效的冠狀動脈收縮劑。Adrenochrome可?于神經(jīng)系統(tǒng)疾病研究。體外研究Adrenochromedecreasesmicrosomalcalciumbinding,calciumuptakeandCa2+-stimulatedMg2+-dependentATPaseactivities.TheinhibitoryeffectofAdrenochromeonmicrosomalcalciumuptakeactivityoftheisolatedmembraneisindependentofpH(6.0-8.0),calciumconcentrations(10-200μM),proteinconcentration(0.02-0.10mg/mL),temperature(25-37degreesC)andincubationtime(2-30min)[2].體內(nèi)研究Inisolatedrathearts,concentrationsofAdrenochromefrom1to1000ng/mLincreasescoronarypressureinadose-andtime-dependentmanner.Furthermore,thedegreeofconstrictionbyAdrenochromeisdependentontheCaCl2concentrationintheperfusionmedium[1].REFERENCES[1].MKarmazyn,,etal.Adrenochrome-inducedcoronaryarteryconstrictionintheratheart.JPharmacolExpTher.1981Oct;219(1):225-30.[2].STakeo,etal.Effectsofadrenochromeoncalciumaccumulatingandadenosinetriphosphataseactivitiesoftheratheartmicrosomes.JPharmacolExpTher.1980Sep;214(3):688-93.[3].KojiUeda,etal.Catecholamineoxidation-mediatedtranscriptionalinhibitioninMnneurotoxicity.JToxicolSci.2020;45(10):619-624.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchus