Manganese-salen-chloride-EUK-8-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEManganese(salen)chlorideCat.No.:HY-W001583CASNo.:53177-12-1Synonyms:EUK-8分?式:C??H??ClMnN?O?分?量:356.69作?靶點(diǎn):Others作?通路:Others儲(chǔ)存?式:Powder-20°C3yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:8.33mg/mL(23.35mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.8036mL14.0178mL28.0355mL5mM0.5607mL2.8036mL5.6071mL10mM0.2804mL1.4018mL2.8036mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性Manganese(salen)chloride(EUK-8)，?種超氧化物歧化酶和過氧化氫酶模擬物，具有氧?由抗氧化劑。Manganese(salen)chloride可減輕內(nèi)毒素?癥豬的急性肺損傷。體外研究Manganese(salen)chloride(25μM;24-72h)protectsorganotypichippocampalslicesfromβ-AP-inducedneurotoxicity,andcompletelyblocksβ-AP-inducedfreeradicalaccumulationandlipidperoxidation[2].1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE體內(nèi)研究Manganese(salen)chloride(25mg/kg;i.p.3timesaweekfor4weeks)reducescardiacoxidativestressandamelioratespressureoverload-inducedheartfailureintheharlequinmousemutant[3].AnimalModel:Wild-type(WT)andharlequin(Hq)B6CBAmaleandfemalemice[3]Dosage:25mg/kg/dayAdministration:I.p.3timesaweekfor4weeksResult:Preventedmyocardialoxidantdamageprovokedbybiomechanicalstress.Improvedsurvivalfollowingbiomechanicalstress.Preventedfunctionalandgeometricaldeteriorationinresponsetopressureoverload.Attenuatednecroticandapoptoticcelldeath,andattenuatedcardiachypertrophyandfibrosis.REFERENCES[1].GonzalezPK,et,al.EUK-8,asyntheticsuperoxidedismutaseandcatalasemimetic,amelioratesacutelunginjuryinendotoxemicswine.JPharmacolExpTher.1995Nov;275(2):798-806.[2].BruceAJ,et,al.beta-Amyloidtoxicityinorganotypichippocampalcultures:protectionbyEUK-8,asyntheticcatalyticfreeradicalscavenger.ProcNatlAcadSciUSA.1996Mar19;93(6):2312-6.[3].EmpelVPM,et,al.EUK-8,asuperoxidedismutaseandcatalasemimetic,reducescardiacoxidativestressandamelioratespressureoverload-inducedheartfailureintheharlequinmousemutant.JAmCollCardiol.2006Aug15;48(4):824-32.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearch