Naphazoline-Naphthazoline-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemENaphazolineCat.No.:HY-111326CASNo.:835-31-4Synonyms:Naphthazoline分?式:C??H??N?分?量:210.27作?靶點(diǎn):AdrenergicReceptor;TNFReceptor;InterleukinRelated;VEGFR作?通路:GPCR/GProtein;NeuronalSignaling;Apoptosis;Immunology/Inflammation;ProteinTyrosineKinase/RTK儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Naphazoline(Naphthazoline)?種有效的α-腎上腺素能受體(α-adrenergicreceptor)激動(dòng)劑。Naphazoline能降低?管通透性和促進(jìn)?管收縮。Naphazoline可降低炎癥因?(TNF-α、IL-1β和IL-6)、細(xì)胞因?(IFN-γ和IL-4)、IgE、GMCSF和NGF的?平。Naphazoline可?于?細(xì)性結(jié)膜炎的研究。IC50&TargetIL-1βIL-6IL-4體內(nèi)研究Naphazoline(0.2mg/kg,10μlpereye;IP,once)reduceshistamineorantigen-inducedconjunctivalvascularhyperpermeabilityinmice,andreducesconjunctivitisinmiceviaeffectsoninflammation,NGFandVEGF[1].AnimalModel:Femalewild-typeBALB/cmice(4-5weeks,18±2g,n=8/group,allergicconjunctivitismousemodelestablishedusinghistamineoranantigen(ovalbumin))[1]Dosage:0.2mg/mL,10μlpereyeAdministration:Intraperitonealinjection(IP),onceResult:inigfitljuticulajuertiit.duindicflaithtoiseaintiosighenlevelsofIL-1β,IL-6,IFN-γ,andIL-4.ReducedthelevelsofIgE,GMCSF,NGFandVEGFinantigen-inducedconjunctivalvascularhyperpermeabilitymice.1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEREFERENCES[1].QuanL,et,al.Treatmentwitholopatadineandnaphazolinehydrochloridereducesallergicconjunctivitisinmicethroughalterationsininflammation,NGFandVEGF.MolMedRep.2016Apr;13(4):3319-25.[2].YamaguchiI,et,al.Centralandperipheraladrenergicmechanismsregulatinggastricsecretionintherat.JPharmacolExpTher.1977Oct;203(1):125-31.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-37