PROTAC-AR-Degrader-4-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEPROTACARDegrader-4Cat.No.:HY-111848CASNo.:1351169-31-7分?式:C??H??N?O?分?量:770.01作?靶點(diǎn):SNIPERs;PROTACs;AndrogenReceptor作?通路:PROTAC;Others儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:200mg/mL(259.74mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM1.2987mL6.4934mL12.9868mL5mM0.2597mL1.2987mL2.5974mL10mM0.1299mL0.6493mL1.2987mL體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥5mg/mL(6.49mM);Clearsolution2.請(qǐng)依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:5mg/mL(6.49mM);Suspendedsolution;NeedultrasonicBIOLOGICALACTIVITY1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE?物活性PROTACARDegrader-4包含IAP配體結(jié)合團(tuán)，linker和雄激素受體(AR)配體結(jié)合團(tuán)。于cIAP1的降解劑也被稱為SNIPER[1]。IC50&TargetcIAP1體外研究SpecificandNongeneticIAPs-dependentProteinErasers(SNIPERs)arebifunctionalcompoundswhicharedesignedbyconjugatinganIAPs-recognitionstructurewithatargetprotein-recognitionstructure.Targetingproteinsfordegradationinvolvesthreesteps.1,itstworecognitionstructuresallowSNIPERtoformacomplexlinkingIAPs,whichhaveE3ligaseactivity,withthetargetprotein.2,thetargetproteinispolyubiquitinatedbyIAPs.3,thepolyubiquitinatedproteinisdegradedbyproteasome.REFERENCES[1].ItohY,etal.Design,synthesisandbiologicalevaluationofnuclearreceptor-degradationinducers.BioorgMedChem.2011Nov15;19(22):6768-78.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-379