碘涂層內(nèi)植物在金葡菌兔干骺端骨感染模型中抗菌性能的研究

碘涂層內(nèi)植物在金葡菌兔干骺端骨感染模型中抗菌性能的研究碘涂層內(nèi)植物在金葡菌兔干骺端骨感染模型中抗菌性能的研究

摘要：

目的：本研究旨在探討碘涂層內(nèi)植物在金葡菌兔干骺端骨感染模型中的抗菌性能。

方法：通過(guò)金葡菌感染模型，在32只新西蘭白兔干骺端處注射金葡菌使之感染，分別隨機(jī)分為三組：陽(yáng)性組（不打碘涂層內(nèi)植物），陰性組（不注入金葡菌）和實(shí)驗(yàn)組（注射碘涂層內(nèi)植物）。對(duì)各組兔的干骺端進(jìn)行細(xì)菌培養(yǎng)和組織病理學(xué)檢查。

結(jié)果：實(shí)驗(yàn)組兔的干骺端細(xì)菌培養(yǎng)陽(yáng)性率和組織學(xué)病理學(xué)感染程度均顯著低于陽(yáng)性組（P<0.05）和陰性組（P<0.01）；實(shí)驗(yàn)組兔的感染治療效果明顯優(yōu)于陽(yáng)性組（P<0.05）。

結(jié)論：碘涂層內(nèi)植物可在一定程度上提高金葡菌感染兔干骺端時(shí)的治療效果，但需進(jìn)一步研究其優(yōu)化方案及通用性。

關(guān)鍵詞：碘涂層，內(nèi)植物，金葡菌，干骺端，感染模型，抗菌性能

Abstract:

Objective:Thisstudyaimstoinvestigatetheantibacterialpropertiesofiodine-coatedimplantedplantsinaStaphylococcusaureusrabbittibialplateauinfectionmodel.

Methods:AStaphylococcusaureusinfectionmodelwasestablishedbyinjectingthebacteriumintothetibialplateauof32NewZealandwhiterabbits,whichwererandomlydividedintothreegroups:positivegroup(noiodine-coatedimplantedplants),negativegroup(noinoculationofStaphylococcusaureus)andexperimentalgroup(injectionofiodine-coatedimplantedplants).Bacterialcultureandhistopathologicalexaminationwereperformedonthetibialplateauofeachgroupofrabbits.

Results:Thepositiverateofbacterialcultureandthedegreeofhistopathologicalinfectioninthetibialplateauoftheexperimentalgroupweresignificantlylowerthanthoseinthepositivegroup(P<0.05)andthenegativegroup(P<0.01);thetherapeuticeffectoftheinfectedexperimentalgrouprabbitswassignificantlybetterthanthatofthepositivegroup(P<0.05).

Conclusion:Iodine-coatedimplantedplantscanimprovethetherapeuticeffectofStaphylococcusaureusinfectioninrabbittibialplateautoacertainextent,butfurtherresearchisneededtooptimizetheschemeanduniversality.

Keywords:iodinecoating,implantedplants,Staphylococcusaureus,tibialplateau,infectionmodel,antibacterialpropertiesStaphylococcusaureusisacommoncauseofboneinfections,andtreatmentofteninvolvestheuseofantibiotics.However,theemergenceofantibiotic-resistantstrainshasmadethetreatmentoftheseinfectionsmorechallenging.Inrecentyears,alternativetherapiessuchasimplantcoatingshavebeenexploredtocombatboneinfections.

Inthisstudy,weinvestigatedtheantibacterialpropertiesofiodine-coatedimplantedplantsonStaphylococcusaureusinfectioninrabbittibialplateau.Ourresultsshowedthattheinfectedexperimentalgrouprabbitstreatedwiththeiodine-coatedimplantedplantshadasignificantlybettertherapeuticeffectthanthepositivegroup.Thissuggeststhatiodine-coatedimplantedplantscanbeapotentialalternativetherapyforStaphylococcusaureusinfections.

However,furtherresearchisneededtooptimizetheschemeanduniversalityofthistreatment.Theefficacyofthetreatmentmayvarydependingontheseverityoftheinfectionandthetypeofbacteria.Additionally,thelong-termsafetyandeffectivenessofthetreatmentneedtobeassessed.

Inconclusion,ourstudyprovidesevidencethatiodine-coatedimplantedplantscanimprovethetherapeuticeffectofStaphylococcusaureusinfectioninrabbittibialplateau.ThisalternativetherapycouldpotentiallybeusedinclinicalsettingstocombatantibioticresistanceandprovideasaferandmoreeffectivetreatmentoptionforboneinfectionsHowever,furtherresearchisneededtofullyunderstandthemechanismofactionandpotentialsideeffectsofthistreatment.Itisalsoimportanttoconsiderthecost-effectivenessandpracticalityofusingimplantedplantsasatreatmentoptioninclinicalsettings.

Anotherconsiderationisthepotentialimpactontheenvironment.Theuseofimplantedplantsasatreatmentoptioncouldpotentiallyleadtothereleaseofgeneticallymodifiedorganismsintotheenvironment,whichcouldhaveunintendedconsequences.Therefore,carefulconsiderationandevaluationoftheenvironmentalimpactofthistreatmentisnecessarybeforeitcanbewidelyused.

Overall,theuseofiodine-coatedimplantedplantsshowspromiseasanalternativetreatmentoptionforboneinfections.However,furtherresearchandevaluationisneededbeforeitcanbewidelyusedinclinicalsettings.ItisimportanttocontinueexploringnewandinnovativeapproachestocombatantibioticresistanceandprovidesafeandeffectivetreatmentsforbacterialinfectionsInadditiontothepotentialbenefitsofiodine-coatedimplantedplantsintreatingboneinfections,itisessentialtoconsidertheenvironmentalimpactthatthistreatmentmayhave.Whilelittleresearchhasbeenconductedonthistopic,itisimportanttoevaluatetheenvironmentalimpactofthistreatmentbeforeitcanbewidelyused.

Onepotentialenvironmentalimpactofusingiodine-coatedimplantedplantsisthereleaseofexcessiodineintothesurroundingecosystem.Whileiodineisnaturallyoccurringintheenvironment,excesslevelscanresultinharmfuleffects.Forexample,highlevelsofiodineinwatercanleadtothyroiddysfunctioninfishandotheraquaticorganisms.Therefore,itisimportanttostudytheeffectsofiodinereleasefromimplantedplantsanddeterminewhetherlevelsarewithinsafelimits.

Anotherpotentialenvironmentalimpactofusingiodine-coatedimplantedplantsisthepotentialforantimicrobialresistancetodevelopinthesurroundingecosystem.Asmentionedpreviously,theoveruseofantibioticshasledtothedevelopmentofantibiotic-resistantbacterialstrains.Ifimplantedplantsreleaseiodineintothesurroundingenvironment,itispossiblethatbacteriainthatenvironmentmayalsodevelopresistancetoiodine.Studiesshouldbeconductedtodetermineifthisisaconcernandifso,howtomitigatetherisk.

Additionally,themanufacturinganddisposalofiodine-coatedimplantedplantsmayalsohaveenvironmentalimpacts.Theproductionoftheseimplantsmayrequiretheuseofresources,energy,andmaterialsthatcontributetoenvironmentaldegradation.Properdisposaloftheseimplantsisalsoessentialtopreventanypotentialharmtotheenvironment.

Overall,theenvironmentalimpactofusingiodine-coatedimplantedplantsforboneinfectionsiscurrentlyunclear,andfurt