Cyclic-GMP-sodium-DataSheet-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemECyclicGMPsodiumCat.No.:HY-113469ACASNo.:40732-48-7分?式:C??H??N?NaO?P分?量:367.19作?靶點:EndogenousMetabolite作?通路:MetabolicEnzyme/Protease儲存?式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性數(shù)據(jù)體外實驗H2O:83.33mg/mL(226.94mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.7234mL13.6169mL27.2339mL5mM0.5447mL2.7234mL5.4468mL10mM0.2723mL1.3617mL2.7234mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。BIOLOGICALACTIVITY?物活性CyclicGMPsodium(cGMP)平滑肌張?的短期變化和對慢性藥物治療或增殖信號的長期反應(yīng)的重調(diào)節(jié)因?，它對?房利鈉肽(ANP)或?氧化氮(NO)都有響應(yīng)。CyclicGMPsodium與陽離?通道相互作?調(diào)節(jié)離?轉(zhuǎn)運或激活，依賴于CyclicGMPsodium的蛋?激酶導(dǎo)致蛋?質(zhì)磷酸化。IC50&TargetHumanEndogenousMetaboliteREFERENCES1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE[1].RybalkinSD,etal.CyclicGMPphosphodiesterasesandregulationofsmoothmusclefunction.CircRes.2003Aug22;93(4):280-91.[2].MuradF.ShattuckLecture.NitricoxideandcyclicGMPincellsignalinganddrugdevelopment.NEnglJMed.2006Nov9;355(19):2003-11.doi:10.1056/NEJMsa063904.PMID:17093251.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021-