食管癌流行病學(xué)特征專家講座

Epidemiology

Etiology食管癌流行病學(xué)特征專家講座第1頁EpidemiologyWorld-wildEstimatedage-standardisedincidenceandmortalityrates:bothsexesWorld第九位？食管癌流行病學(xué)特征專家講座第2頁EpidemiologyWorld-wildEstimatedage-standardisedincidenceandmortalityrates:bothsexesWorld食管癌流行病學(xué)特征專家講座第3頁EpidemiologyEstimatedage-standardisedincidenceandmortalityratesinChina:bothsexesChina第六位？食管癌流行病學(xué)特征專家講座第4頁EpidemiologyEstimatedage-standardisedincidenceandmortalityratesinChina:bothsexesChina食管癌流行病學(xué)特征專家講座第5頁EpidemiologyOesophagealcanceristhe8thmostcommoncancerworldwide,withanestimated456,000newcasesin(3.2%ofthetotal),andthe6thmostcommoncauseofdeathfromcancerwithanestimated400,000deaths(4.9%ofthetotal).Thesefiguresincludebothadenocarcinomaandsquamouscellcarcinomasub-types.Around80%ofthecasesworldwideoccurinlessdevelopedregions.食管癌流行病學(xué)特征專家講座第6頁EpidemiologyOesophagealcancerincidenceratesworldwideinmenaremorethandoublethoseinwomen(male:femaleratio2.4:1).Inbothsexestherearemorethan20-folddifferencesinincidencebetweenthedifferentregionsoftheworld,withratesrangingfrom0.8per100,000inWesternAfricato17.0per100,000inEasternAsiainmen,and0.2per100,000inMicronesia/Polynesiato7.8per100,000inEasternAfricainwomen.食管癌流行病學(xué)特征專家講座第7頁EpidemiologyCanceroftheoesophagushasaverypoorsurvival(overallratioofmortalitytoincidenceof0.88),andtheoesophagealcancermortalitycloselyfollowsthegeographicalpatternsforincidence,withthehighestmortalityratesoccurringinEasternAsia(14.1per100,000)andSouthernAfrica(12.8)inmenandinEastern(7.3)andSouthernAfrica(6.2)inwomen.食管癌流行病學(xué)特征專家講座第8頁EpidemiologyEstimatedOesophagealCancerincidence/MortalityWorldwidein:Men食管癌流行病學(xué)特征專家講座第9頁我國食管癌發(fā)病率也存在地域差異。食管癌高發(fā)省份為河北、河南、福建和重慶，其次為新疆、江蘇、山西、甘肅和安徽。食管癌在太行山脈附近省份顯著高發(fā)，河南林州食管癌與賁門癌發(fā)病率最高，占當(dāng)?shù)厝繍盒阅[瘤81.4％。Epidemiology食管癌流行病學(xué)特征專家講座第10頁EtiologyRemainsunclear亞硝胺及真菌上皮增生變性；真菌分解硝酸鹽為亞硝酸鹽，發(fā)霉前50~100倍遺傳原因和基因河南林縣有家族史者占60%；食管癌患者染色體與基因變異增多；C-myc、EGFR等激活營養(yǎng)不良及微量元素缺乏高發(fā)區(qū)飲食調(diào)查發(fā)覺食物缺乏動物蛋白質(zhì)，VitB1、B2、A、C；金屬元素Cu、Mn、Fe、Zn食管癌流行病學(xué)特征專家講座第11頁EtiologyRemainsunclear