DNMT-HDAC-IN-1-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEDNMT/HDAC-IN-1Cat.No.:HY-158075CASNo.:2095619-17-1分?式:C??H??ClF?N?O?分?量:412.79作?靶點:HDAC;DNAMethyltransferase作?通路:CellCycle/DNADamage;Epigenetics儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性DNMT/HDAC-IN-1(Compund15a)?種DNMT和HDAC雙重抑制劑，對HDAC1和HDAC6的IC50值分別為56.84nM和17.39nM。DNMT/HDAC-IN-1可誘導(dǎo)細(xì)胞凋亡(Apoptosis)，?于腫瘤的研究。IC50&TargetHDAC1HDAC656.84nM(IC50)17.39nM(IC50)體外研究DNMT/HDAC-IN-1significantlysuppressK562andU937proliferationwithIC50valuesof2.85and1.06mM,respectively[1].WesternBlotAnalysis[1]CellLine:U937cellsConcentration:0,1,2.5,5μMIncubationTime:12hResult:inducedhistoneH3K9andhistoneH4K8acetylationandincreasedP16expression.ApoptosisAnalysis[1]CellLine:U937cellsConcentration:2.5,5,10μM1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEIncubationTime:36hResult:inducedapoptosisinU937cells.REFERENCES[1].YuanZ,etal.Design,synthesisandanticancerpotentialofNSC-319745hydroxamicacidderivativesasDNMTandHDACinhibitors.EurJMedChem.2017Jul7;134:281-292.[2].HuangW,etal.DualinhibitorsofDNMTandHDACinduceviralmimicrytoinduceantitumourimmunityinbreastcancer.CellDeathDiscov.2024Mar15;10(1):143.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: