MK-0493-hydrochloride-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEMK-0493hydrochlorideCat.No.:HY-118930ACASNo.:455957-71-8分?式:C??H??Cl?F?N?O?分?量:582.55作?靶點:MelanocortinReceptor作?通路:GPCR/GProtein;NeuronalSignaling儲存?式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性數(shù)據(jù)體外實驗DMSO:200mg/mL(343.32mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.7166mL8.5830mL17.1659mL5mM0.3433mL1.7166mL3.4332mL10mM0.1717mL0.8583mL1.7166mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。BIOLOGICALACTIVITY?物活性MK-0493hydrochloride有效的、具有?服活性的、選擇性的??質(zhì)激素受體4(MC4R)的激動劑，可明顯減少?物攝?。REFERENCES[1].KrishnaR,etal.Potentandselectiveagonismofthemelanocortinreceptor4withMK-0493doesnotinduceweightlossinobesehuman1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEsubjects:energyintakepredictslackofweightlossefficacy.ClinPharmacolTher.2009Dec;86(6):659-66.[2].SezenSF,etal.Intracavernosalpressuremonitoringinmice:responsestoelectricalstimulationofthecavernousnerveandtointracavernosaldrugadministration.JAndrol.2000Mar-Apr;21(2):311-5.[3].HongQ,etal.Discoveryofapiperazineureabasedcompoundasapotent,selective,orallybioavailablemelanocortinsubtype-4receptorpartialagonist.BioorgMedChemLett.2011Apr15;21(8):2330-4.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955