藥理學(xué)智慧樹(shù)知到答案2024年南開(kāi)大學(xué)

藥理學(xué)南開(kāi)大學(xué)智慧樹(shù)知到答案2024年第一章測(cè)試

WhichofthefollowingdrugsisaninducerofCYP1A2(

)

A:SimvastatinB:FluconazoleC:Tobacco

D:Ciprofloxacin

答案:CTheprocessofrenalexcretionofdrugsdoesnotincludewhichofthefollowingoptions(

)

A:HepatoentericcirculationB:passivetubulereabsorptionC:Glomerularfiltration

D:Activesecretionofrenaltubules

答案:AWhichofthefollowingstatementsisfalse(

)

A:Thalf（T1/2）ofadrugreferstothetimerequiredfortheplasmaconcentrationofthedrugtodropbyhalfB:ThetimerequiredtoreachhalfofCmaxbyoraladministrationisdifferentfromthetimerequiredforhalfofCmaxintravenouslyC:TmaxreferstothetimethattakesadrugorothersubstancetoreachthemaximumconcentrationCmaxD:AUCreferstoAreaunderthecurve(pharmacokinetics),regardingplasmadrugconcentration-timecurves

答案:BThemainfactorsaffectingdrugabsorptionare(

)

A:AdministrationrouteB:pHvalueC:Thefirstpasseffect

D:Bloodflow

答案:ABCDThebioavailabilityofthedrugrefersto（

）

A:ThefractionorpercentageofadrugthatreacheshepaticportalcirculationB:ThefractionorpercentageofadrugthatreachessystemiccirculationC:TherelativespeedofthedrugabsorptionintothebodyD:Thefractionorpercentageofadrugthatreachestheactionpoint

答案:B

第二章測(cè)試

Whichofthefollowingoptionsiswrongabouttheantagonist(

)

A:Acompetitiveantagonistbindstothedifferentsiteastheendogenoussignalingmolecule,blockingitsbindingsiteatthereceptorB:AntagonisthavebindingaffinitytoreceptorbuttheyhavenointrinsicactivitC:Antagonistaretypicallyclassifiedascompetitiveandnon-competitivD:Antagonistsaredrugsthatdecreaseoropposetheactionsofanotherdrugorendogenousligand

答案:AWhichofthefollowingstatementsiswrong（

）

A:TheratioofED50toLD50istermedthetherapeuticindexanddiffersforeachdrugB:Effectivedose(ED)referstotheminimaldrugamountrequiredtoachievethemaximumeffectC:Thehigherthetherapeuticindex,thesaferthedrug,astheriskofatoxicorlethaloverdosedecreasD:Thepotencynotonlydependsontheefficacyofadrug,butalsoonitsbindingaffinityatthetargetsite

答案:AThetherapeuticindexrefersto（

）

A:

LD5/ED95B:

ED50/LD5C:LD50/ED50

D:

ED95/LD5

答案:CIfadrugbindstoareceptorandproducessomebiologicresponsesthatmimicstheresponsetotheendogenousligand,thedrugbelongsto(

)

A:AntagonistB:Stimulant

C:Agonist

D:Inhibitor

答案:CWhichofthefollowingstatementsaboutthereceptoriscorrect?

A:AlldrugsworkbystimulatingorblockingthecorrespondingreceptorsB:ReceptorreferstoaproteinthatbindstoaligandandproducesameasurableresponseC:ReceptorsarepolysaccharidesonthecellmembraneD:Theeffectscausedbythebindingofreceptorsandligandsoragonistsareexcitatoryeffects

答案:B

第三章測(cè)試

Whichofthefollowingoptionsbelongstoselectiveβ1blockers(

)

A:AcebutololB:MetoprololC:LabetalolD:Atenolol

答案:CWhichofthefollowingoptionsarelong-actingreceptoragonists?

A:SalmeterolB:TerbutalineC:Formoterol

D:Albuterol

答案:ACWhichofthefollowingisananticholinesterasedrug（

）

A:NeostigmineB:AcetylcholineC:PilocarpineD:Carbachol

答案:ACholinergicreceptorsinclude（

）

A:Muscarinicreceptors

B:βreceptorsC:NicotinicreceptorsD:αreceptors

答案:AC

NicotinicreceptorsareGproteincoupledreceptors,andtheiractivationwillincreasepermeabilityofsodiumorcalciuminpostganglionicneuronsorskeletalmuscles,hencetheyarealwaysexcitatory.Istheabovestatementcorrect.

A:對(duì)B:錯(cuò)

答案:B

第四章測(cè)試

Whichofthefollowingantiarrhythmicdrugsiscardiotoxic(

)

A:VerapamilB:DigoxinC:LidocaineD:Magnesiumsulfate

答案:BWhichofthefollowingdrugscanbeusedforQTmonitoringofhospitalizedpatients（

)

A:Dofetilide

B:

IbutilideC:AmiodaroneD:Sotalol

答案:ADAsthmaandCOPDarenotcontraindicationsforwhichofthefollowingdrugs(

)

A:LabetalolB:Metoprolol

C:CarvedilolD:

Pindolol

答案:BThesideeffectsofquinidinedonotincludewhichofthefollowingoptions(

)

A:

DiarrheaB:TinnitusC:

ConstipationD:

lurredvision

答案:CAccordingtotheirmainmechanismofaction,antiarrhythmicdrugsincludewhichofthefollowingcategories(

)

A:SodiumchannelblockersB:PotassiumchannelC:β-blockersD:Blockerscalciumchannelblockers

答案:ABCD

第五章測(cè)試

A40-year-oldmalehasrecentlybeendiagnosedwithhypertensionduetopressurereadingsof163/102and165/100mmHg.Healsohasdiabetesthatiswellcontrolledwithoralhypoglycemicmedications.Whichisthebestinitialtreatmentregimenfortreatmentofhypertensioninthispatient?

A:LisinopriB:FelodipineC:FurosemideD:MetoproloE:Lisinoprilandhydrochlorothiazide

答案:EA48-year-oldhypertensivepatienthasbeensuccessfullytreatedwithathiazidediureticforthelast5years.Overthelast3months,hisdiastolicpressurehassteadilyincreased,andhewasstartedonanadditionalantihypertensiveagent.Hecomplainsofseveralinstancesofbeingunabletoachieveanerectionandnotbeingabletocompletethreesetsoftennisasheoncedid.Whichisthelikelysecondantihypertensivemedication?

A:CaptoprilB:MetoprololC:LosartanD:MinoxidilE:Nifedipine

答案:BWhichcanprecipitateahypertensivecrisisfollowingabruptcessationoftherapy?

A:LosartanB:HydrochlorothiazideC:DiltiazemD:ClonidineE:Enalapril

答案:DWhichmaycausereflextachycardiaand/orposturalhypotensiononinitialadministration?

A:PrazosinB:VerapamilC:MetoprololD:HydrochlorothiazidE:Atenolol

答案:AA45-year-oldmanwasjuststartedontherapyforhypertensionanddevelopedapersistent,drycough.Whichismostlikelyresponsibleforthissideeffect?

A:NifedipinB:PropranololC:LosartanD:PrazosinE:Enalapril

答案:E

第六章測(cè)試

BCisa70-year-oldfemalewhoisdiagnosedwithHFrEF.Herpastmedicalhistoryissignificantforhypertensionandatrialfibrillation.Sheistakinghydrochlorothiazide,lisinopril,metoprololtartrate,andwarfarin.BCsayssheisfeeling“good”andhasnocough,shortnessofbreath,oredema.Whichisthemostappropriatemedicationchangetomake

A:DecreasewarfarindosB:ChangelisinopriltolosartanC:DiscontinuehydrochlorothiazideD:Changemetoprololtartratetometoprololsuccinate

答案:DHowdoβ-blockersimprovecardiacfunctioninHF?

A:BydecreasingcardiacremodelingB:ByincreasingheartrateC:ByincreasingreninreleaseD:Byactivatingnorepinephrine

答案:AWhatmakeslosartandifferentfromotherARBs?

A:Losartanhastheshortesthalf-lifeB:

LosartanhasanactivemetabolitC:LosartanhasasmallvolumeofdistributionD:

Losartanisrenallyeliminated

答案:BWhichbestdescribestheactionofACEinhibitorsonthefailingheart?

A:ACEinhibitorsincreasevascularresistanceB:ACEinhibitorsreducepreloadC:ACEinhibitorsdecreasecardiacoutpuD:ACEinhibitorsincreasealdosteron

答案:BWhichdrugmayexacerbateHF?

A:CetirizineB:

AcetaminophenC:

IbuprofenD:Chlorthalidone

答案:C

第七章測(cè)試

Whichsideeffectisassociatedwithamlodipine?

A:CoughB:

EdemaC:QTprolongationD:Bradycardia

答案:BA62-year-oldpatientwithahistoryofasthmaandvasospasticanginastatesthathegetschestpainbothwithexertionandatrest,abouttentimesperweek.Onesublingualnitroglycerintabletalwaysrelieveshissymptoms,butthismedicationgiveshimanawfulheadacheeverytimehetakesit.Whichisthebestoptionforimprovinghisangina

A:ReplacenitroglycerinwithranolazineB:ChangetosublingualnitroglycerinsprayC:AddamlodipineD:Addpropranolol

答案:CA72-year-oldmalepresentstotheprimarycarecliniccomplainingofchesttightnessandpressurethatisincreasinginseverityandfrequency.Hiscurrentmedicationsincludeatenolol,lisinopril,andnitroglycerin.Whichinterventionismostappropriateatthistime?

A:AddamlodipineB:InitiateisosorbidemononitrateC:InitiateranolazineD:Referthepatienttothenearestemergencyroomforevaluatio

答案:DAllofthefollowingmedicationscanbeusefulformanagingstableanginainapatientwithcoronaryarterydiseaseexcept:

A:IsosorbidedinitrateB:AmlodipineC:Immediate-releasenifedipineD:Atenolol

答案:CWhatistheclinicaltermforanginacausedbycoronaryvasospasm?

A:UnstableanginaB:MyocardialinfarctionC:PrinzmetalanginaD:Classicangina

答案:C

第八章測(cè)試

Whichsideeffectisassociatedwithamlodipine

A:BradycardiB:QTprolongationC:EdemD:Cough

答案:CA62-year-oldpatientwithahistoryofasthmaandvasospasticanginastatesthathegetschestpainbothwithexertionandatrest,abouttentimesperweek.Onesublingualnitroglycerintabletalwaysrelieveshissymptoms,butthismedicationgiveshimanawfulheadacheeverytimehetakesit.Whichisthebestoptionforimprovinghisangina?

A:AddpropranololB:ChangetosublingualnitroglycerinsprayC:AddamlodipineD:Replacenitroglycerinwithranolazine

答案:CA72-year-oldmalepresentstotheprimarycarecliniccomplainingofchesttightnessandpressurethatisincreasinginseverityandfrequency.Hiscurrentmedicationsincludeatenolol,lisinopril,andnitroglycerin.Whichinterventionismostappropriateatthistime?

A:

InitiateranolazineB:InitiateisosorbidemononitrateC:ReferthepatienttothenearestemergencyroomforevaluationD:Addamlodipine

答案:CAllofthefollowingmedicationscanbeusefulformanagingstableanginainapatientwithcoronaryarterydiseaseexcept:

A:AtenololB:

AmlodipineC:Immediate-releasenifedipineD:Isosorbidedinitrate

答案:CWhatistheclinicaltermforanginacausedbycoronaryvasospasm？

A:MyocardialinfarctionB:PrinzmetalanginaC:

ClassicanginaD:Unstableangina

答案:B

第九章測(cè)試

Whichofthefollowingoptionsdoesnotbelongtotheclinicalapplicationofglucocorticoids

A:ForthediagnosisofCushing’ssyndromeB:

Foranti-inflammatory/immunosuppressivetherapyC:ForthetherapytofuberculosisD:ReplacementtherapyforpatientswithAddison’sdisease

答案:CWhichofthefollowingoptionsarecontraindicationstoglucocorticoids(

)

A:GlaucomaB:PepticulcerC:DiabetesD:Osteoporosis

答案:ABCDGlucocorticoidscanbeadministeredorally,systemicallyorintra-articularly.Istheabovestatementcorrect

A:錯(cuò)B:對(duì)

答案:BWhichofthefollowingoptionsisnotanadversereactionofglucocorticoids(

)

A:InducingworseningulcersB:HypoglycemiaC:

GlycosuriaD:Inducingaggravatedinfection

答案:BLong-termuseofglucocorticoidscancause(

)

A:HighbloodcalciumB:HighbloodpotassiumC:HighbloodphosphorusD:Lowbloodpotassium

答案:D

第十章測(cè)試

Metforminiscontraindicatedinwhichofthefollowingpatients(

)

A:

Hypertension

B:RenalinsufficiencyC:LiverinsufficiencyD:Gastriculcer

答案:BWhichofthefollowinghypoglycemicdrugscanNOTstimulatethepancreaticbetacellstosecreteinsulin(

)

A:NateglinideB:GlimepirideC:PioglitazoneD:Repaglinide

答案:CWhichofthefollowinghypoglycemicdrugsisanα-glucosidaseinhibitor(

)

A:CanagliflozinB:MiglitolC:MetforminD:Acarbose

答案:BDWhichofthefollowingoptionsisthemostseriousadversereactionofmetformin（

）

A:LacticacidosisB:

LethargyC:EdemaD:Constipation

答案:AWhichofthefollowingdrugscancauseweightlossinpatients(

)

A:InsulinGlarginB:InsulinLisprC:LiraglutideD:Exenatide

答案:CD

第十一章測(cè)試

Thefollowingdrugsthatcancauseleukopeniaare(

)

A:CarbimazoleB:

Iodide

C:MethimazoleD:Propylthiouraci

答案:ACDPropylthiouracil,carbimazoleandmethimazolecausesfetaltoxicities,likefetalgoiter,choanalatresia,scalpdefectsandaplasiacutis.Istheabovestatementcorrec

A:對(duì)B:錯(cuò)

答案:BThemechanismofactionofpropylthiouracilis(

)

A:InhibitthebiosynthesisofthyroxinB:InhibitthyroiduptakeofiodineC:

InhibitTSHsecretionD:Inhibitthereleaseofthyroxine

答案:A

Whichofthefollowingantithyroiddrugsisnotsuitableforchildren(

)

A:CarbimazoleB:

Propylthiouracil

C:MethimazoleD:Iodide

答案:BWhichofthefollowingoptionsisnotanadversereactionofpropylthiouracil(

)

A:

RashB:HypothyroidismC:FetaltoxicityD:Jointpain

答案:C

第十二章測(cè)試

Followingisthemaininhibitorytransmitterinthebrain(

)

A:Glycine

B:GABAC:NorepinephrineD:Dopamine

答案:BWhichoneofthefollowingchemicalsdoessatisfythecriteriaforaneurotransmitterroleintheCNS?

A:AcetylcholineB:NitricOxideC:GlycineD:SubstancePE:Dopamine

答案:ACDEFollowingisaG-proteincoupledreceptor(

)

A:Kainate

B:AMPAC:MetabotropicD:NMDA

答案:CNeurotransmittersmay(

)

A:IncreasechlorideconductancetocauseinhibitionB:IncreasepotassiumconductancetocauseexcitationC:Incresesodiumconductancetocauseinhibition

D:Increasecalciumconductancetocauseinhibition

答案:A

Substancesecretedintothebloodbyaneuronis(

)

A:NeurotransmitterB:NeuromodulatorC:

Neurohormone

D:Neuromediator

答案:C

第十三章測(cè)試

WhichagentisbestusedintheEmergencyRoomsettingforpatientswhoarebelievedtohavereceivedtoomuchofabenzodiazepinedrugortakenanoverdoseofbenzodiazepines?

A:DoxepinB:DiazepamC:FlumazenilD:NaloxoneE:Ramelteon

答案:CFollowingisGABAAagonist(

)

A:NoneoftheaboveB:MuscimolC:BicucullineD:Baclofen

答案:BThemostlikelyexplanationfortheincreasedsensitivityofelderlypatientstoasingledoseoftriazolamandothersedative-hypnoticdrugsis(

)

A:IncreasedcerebralbloodflowB:ChangesinbrainfunctionthataccompanytheagingprocessC:ChangesinplasmaproteinbindingD:DecreasedrenalfunctionE:

Decreasedhepaticmetabolismoflipidsolubledrugs

答案:BWhichoneofthefollowingstatementsiswrongregardingtheanxiolyticandhypnoticagents?

A:Phenobarbitalisusefulinthetreatmentofacuteintermittentporphyria.B:DiazepamandphenobarbitalinducethecytochromeP450enzymesystem.C:Buspironehasactionssimilartothoseofthebenzodiazepines.D:Phenobarbitalshowsanalgesicproperties.E:Phenobarbitalinducesrespiratorydepression,whichisenhancedbytheconsumptionofethanol.

答案:ABCDWhichoneofthefollowingstatementsiscorrectregardingbenzodiazepines?

A:Benzodiazepines,likeotherCNSdepressants,readilyproducegeneralanesthesia.B:Allbenzodiazepineshavesomesedativeeffects.C:Benzodiazepinesshowanalgesicactions.D:Benzodiazepinesdirectlyopenchloridechannels.E:Clinicalimprovementofanxietyrequires2to4weeksoftreatmentwithbenzodiazepines.

答案:B

第十四章測(cè)試

Followinggeneralanestheticisnotmetabolized(

)

A:IsofluraneB:HalothaneC:NitrousoxideD:Ether

答案:CFourstagesofgeneralanesthesiaaredistinctlyseenwiththeuseof(

)

A:NitrousoxideB:DiethyletherC:EnfluraneD:Halothane

答案:BApatientwithheartfailureandsignificantlyreducedcardiacoutputrequiressurgicalanesthesia.Whichofthefollowingwouldyouexpecttoseeinthispatient?

A:SlowerinductiontimewithinhaledanestheticsB:SlowerinductiontimewithIVanestheticsC:EnhancedremovalofinhaledanestheticstoperipheraltissuesD:NeedforincreaseddosageofIVanesthetics

答案:BWhichoneofthefollowingisapotentintravenousanestheticbutaweakanalgesic?

A:KetamineB:BenzodiazepinesC:IsofluraneD:FentanylE:Propofol

答案:EWhichofthefollowingisapotentanalgesicbutaweakanesthetic?

A:MidazolamB:EtomidateC:HalothanD:ThiopentaE:Nitrousoxid

答案:E

第十五章測(cè)試

Aprominenttoxiceffectoflocalanaestheticsis(

)

A:CNSstimulationB:TachycardiaC:LocalischemiaD:CNSdepressionE:Noneoftheabove

答案:AA32-year-oldwomanrequestsanepiduraltoeaselaborpains.ShereportsthatshehadanallergicreactiontoNovocain(procaine)atthedentist’soffice.Whichofthefollowinglocalanestheticswouldbeappropriateforuseinanepiduralforthispatient?

A:Mepivacaine.B:Tetracaine.C:Ropivacaine.D:Chloroprocaine.

答案:CToxicitiesoflocalanaestheticsinclude(

)

A:Cardiovasculararrhythmiasandcollapse(bupivacaine)

B:Hypertensiveemergencies,strokes(procaine)C:Convulsions(lidocaine)

D:MethemoglobinemiaE:

Dizziness,sedation(lidocaine)

答案:ACDEWhichofthefollowingiswrongregardinglocalanesthetics?

A:Theyhaveeitheralipophilicorahydrophilicgroup.B:Intheirionizedform,theyinteractwiththeproteinreceptorofcalciumchannels.C:Theyhaveeitheranamideoranesterlinkage.D:TheyareunaffectedbypHofthetissueandpKaofthedrug.E:Theyaffectonlysmall,unmyelinatednervefibers.

答案:ABDEWhichoneofthefollowingstatementsaboutthetoxicityoflocalanaestheticsismostcorrect?

A:SeriouscardiovascularreactionsaremorelikelytooccurwithtetracainethanwithbupivacaineB:Cyanosismayoccurfollowinginjectionoflargedosesoflidocaine,especiallyinpatientswithpulmonarydisease

C:Inoverdosage,hyperventilation(withoxygen)ishelpfultocorrectacidosisandlowerextracellularpotassiumD:MostlocalanaestheticscausevasoconstrictionE:.Intravenousinjectionoflocalanaestheticsmaystimulateectopiccardiacpacemakeractivity

答案:C

第十六章測(cè)試

Whichofthefollowingdrugsismostusefulforthe

treatmentofabsenceseizures?（

）

A:Topiramate.B:Levetiracetam.C:Lamotrigine.D:Zonisamide.E:Tiagabine.

答案:CWhichofthefollowingisafirst-linemedicationfor

generalizedtonic–clonicseizures?（

）

A:Ethosuximide.B:Ezogabine.C:Vigabatrin.D:Felbamate.E:Topiramate.

答案:EA9-year-oldboyissentforneurologicevaluation

becauseofepisodesofapparentinattention.Overthe

pastyear,thechildhasexperiencedepisodesduring

whichhedevelopsablanklookonhisfaceandhis

eyesblinkfor15seconds.Heimmediatelyresumeshis

previousactivity.Whichonethefollowingbestdescribes

thispatient’sseizures?（

）

A:Tonic–clonic.B:Absence.C:Complexpartial.D:Myoclonic.E:Simplepartial.

答案:BA25-year-oldwomanwithmyoclonicseizuresiswell

controlledonvalproate.Sheindicatesthatsheis

interestedinbecomingpregnantinthenextyear.With

respecttoherantiepilepsymedication,whichofthe

followingshouldbeconsidered?（

）

A:Consideraddingasecondantiepilepsymedication.B:Leaveheronhercurrenttherapy.C:Decreasehervalproatedose.D:Considerswitchingtolamotrigine.

答案:DApatientwithfocalcomplexpartialseizureshasbeentreatedfor6monthswithcarbamazepinebut,recently,

hasbeenexperiencingbreakthroughseizuresonamorefrequentbasis.Youareconsideringaddinga

seconddrugtotheantiseizureregimen.Whichofthe

followingdrugsisleastlikelytohaveapharmacokinetic

interactionwithcarbamazepine?（

）

A:Zonisamide.B:Lamotrigine.C:Topiramate.D:Tiagabine.E:

Levetiracetam.

答案:E

第十七章測(cè)試

Insmallintestine,morphineparticularlyaffects(

)

A:DoesnotaffectsmallintestinB:IleumC:Duodenum

答案:CWhichofthefollowingstatementsregardingmethadoneiswrong?

A:Theactivemetabolitesofmethadoneaccumulateinpatientswithrenaldysfunction.B:Thedurationofanalgesiaformethadoneismuchshorterthantheeliminationhalf-life.C:Theequianalgesicpotencyofmethadoneissimilartothatofmorphine.D:Methadoneisanexcellentchoiceforanalgesiainmostpatientssincetherearelimiteddrug–druginteractions.

答案:ACDWhichofthefollowingopioidsistheLEASTlipophilic?

A:

Fentanyl.B:Morphine.C:

Meperidine.D:Methadone.

答案:BMorphinestimulates(

)

A:NonpropulsiverhythmiccontractionsofsmallintestineofmanB:HumanuterusatfulltermC:PropulsiveperistalticwavesincolonD:BillaryandpancreaticsecretionsE:Propulsivecontractionsinsmallintestineofman

答案:AWhichofthefollowingstatementsaboutfentanyliscorrect?

A:Theactivemetabolitesoffentanylcancauseseizures.B:Itismosteffectivebyoraladministration.C:Itswithdrawalsymptomscanberelievedbynaloxone.D:Fentanylis100timesmorepotentthanmorphine.

答案:D

第十八章測(cè)試

Analgesiceffectsofaspirin:

A:subcorticalsiteofactioB:neitherC:peripheralaction(inflammation)D:both

答案:DNSAIDprimarilypromotedasananalgesic,notasananti-inflammatoryagent:

A:NaproxenB:sulindacC:KetorolacD:PiroxicamE:Ibuprofen

答案:CNSAIDprimarilypromotedasananalgesic,notasananti-inflammatoryagent:

A:sulindacB:ketorolaC:ibuprofenD:naproxenE:piroxicam

答案:BMediatormostlikelytopromotepain(

)

A:prostaglandinsB:bradykininC:leukotrienesD:serotoninE:histamine

答案:BMechanismofaction:aspirin-plateleteffects:

A:promotesplateletaggregationB:neitherC:bothD:activatesthromboxanesynthesis

答案:B

第十九章測(cè)試

Antihistamines,phenothiazines,tricyclicantidepressantsandantiparkinsonianagentshaveacommonpropertythat(

)

A:Allhavelongplasmahalf-lifeB:AllproducesCNSstimulationC:AllhaveadrenergicactionD:Allhavesomeatropinelikeaction

答案:CPeripheraladverseeffectsoflevodopa,includingnausea,hypotension,andcardiacarrhythmias,canbediminishedbyincludingwhichofthefollowingdrugsinthetherapy?

A:Tolcapone.B:Pramipexole.C:Ropinirole.D:Amantadine.E:Carbidopa.

答案:EWhichmedicationisaglutamatereceptorantagonistthatcanbeusedincombinationwithanacetylcholinesteraseinhibitortomanagethesymptomsofAlzheimer’sdisease?

A:Memantine.B:Rivastigmine.C:Donepezil.D:Ropinirole.E:Fluoxetine.

答案:ATolerancetotheantiparkinsonianactiondevelopsmostrapidlyinthecaseof(

)

A:Amantadine

B:BromocriptineC:Levodopa+carbidopaD:Levodopa

答案:ATheantiparkinsoniandrugwhichactsbyinhibitingthedegradationofdopamineinthebrainis(

)

A:SelegilineB:

BromocriptineC:CarbidopaD:Amantadine

答案:A

第二十章測(cè)試

Whichantipsychotichasthemostsedativepotentialandissometimesquestionablyusedasahypnoticagentincertainclinicalsettings?

A:Quetiapine.B:Fluphenazine.C:Iloperidone.D:

HaloperidolE:Thiothixene.

答案:AWhichoneofthefollowingantipsychoticshasbeenshowntobeapartialagonistatthedopamineD2receptor?

A:

Aripiprazole.B:Clozapine.C:Thioridazine.D:Risperidone.E:Haloperidol

答案:AWhichantidepressanthas,asitstwoprinciplemechanismsofaction,5-HT2Areceptorantagonismandα2receptorantagonism?

A:

MirtazapineB:Doxepin.C:Selegiline.D:Maprotiline.E:Fluoxetine.

答案:AWhichantidepressantisthemostsedating?

A:Fluoxetine.B:CitalopramC:Venlafaxine.D:Duloxetine.E:Nortriptyline.

答案:EWhichantidepressanthas,asitstwoproposedprinciplemechanismsofaction,5-HT1areceptorpartialagonismand5-HTreuptakeinhibition?

A:Vilazodone.B:

Fluoxetine.C:Maprotiline.D:Aripiprazole.E:Mirtazapine.

答案:A

第二十一章測(cè)試

Recreationaluseofdrugssometimesleadstodependence.Whichofthefollowingisleastlikelytocausephysicaldependence?

A:AlcoholincreasesADAproductionB:Alcoholhasadirectstimulatoryeffectonsexualresponsiveness

C:AlcoholisexcitatoryinnatureD:Alcoholisteratogenic

答案:DMentalretardation,microcephaly,andunderdevelopmentofthemidfaceregioninaninfantisassociatedwithchronicmaternalabuseof（

）

A:MescalineB:AmphetamineC:PhencyclidineD:EthanolE:Cocaine

答案:DA35-year-oldmanhasbeenabusingcocaineandisagitated,tachycardic,hypertensive,andhyperthermic.Whichofthefollowingiscorrectregardingtreatmentinthissituation?

A:PhenobarbitalshouldbethefirstchoiceasananticonvulsantB:Thispatientshouldundergogastriclavage;thatis,heshouldhavehisstomachpumpedimmediately.C:Benzodiazepineswouldbeagoodchoice,astheyshouldhelpcalmthepatientdown,decreaseheartrate,decreasebloodpressur