Macrophage-activating-lipopeptide-2-TFA-MALP-2-TFA-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEMacrophage-activatinglipopeptide2TFACat.No.:HY-P10586ASynonyms:MALP-2TFA分?式:C??H???N??O??S.xC?HF?O?Sequence:{S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]Cys}-Gly-Asn-Asn-Asp-Glu-Ser-Asn-Ile-Ser-Phe-Lys-Glu-LysSequenceShortening:{S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]Cys}-GNNDESNISFKEK作?靶點:Toll-likeReceptor(TLR);NOSynthase作?通路:Immunology/Inflammation儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Macrophage-activatinglipopeptide2TFA?種脂肽Toll樣受體TLR-2/TLR-6激動劑。Macrophage-activatinglipopeptide2可增強(qiáng)內(nèi)??氧化氮合酶(eNOS)磷酸化和內(nèi)?細(xì)胞釋放NO，從?改?管舒張。Macrophage-activatinglipopeptide2可增強(qiáng)?細(xì)胞的內(nèi)?粘附，并改接受實驗性股動脈結(jié)扎(FAL)的?膽醇?癥Apoe缺陷??后肢的灌注恢復(fù)和側(cè)??長。體外研究Macrophage-activatinglipopeptide2(1μg/mL,24h)canpromotetheexpressionofmajorendothelialadhesionmoleculesandleukocyteintegrinreceptors,therebyenhancingleukocyteendothelialadhesion[1].Macrophage-activatinglipopeptide2(1μg/mL,2h)canpromotethephosphorylationofproteinkinaseBandeNOSinendothelialMyEndcells,therebypromotingNOrelease[1].體內(nèi)研究Macrophage-activatinglipopeptide2(1μgin125μLPBS;oncedaily;10days;i.v.)canimprovehindlimbperfusionrecoveryandcollateralgrowthinApoedeficientmicewithexperimentalfemoralarteryligation(FAL)andhypercholesterolemia[1].REFERENCES[1].TroidlK,etal.TheLipopeptideMALP-2PromotesCollateralGrowth.Cells.2020Apr16;9(4):997.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955