NOD1-antagonist-2-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemENOD1antagonist-2Cat.No.:HY-170447分?式:C??H??Cl?F?N?O?S?分?量:560.38作?靶點:NOD-likeReceptor(NLR)作?通路:Immunology/Inflammation儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性NOD1antagonist-2(compound66)?種?服有效的選擇性拮抗劑，可抑制?類和??的NOD1。NOD1拮抗NOD1antagonist-2(compound66)可以阻斷NOD1誘導(dǎo)的NF-κB和MAPK途徑。IC50&TargethNOD1mNOD10.8nM(IC50,inHEK293cells)32nM(IC50,inHEK293cells)體外研究NOD1antagonist-2(compound66)demonstratespromisingantagonisticactivityagainstbothh/mNOD1-inducedNF-κBactivationinHEK293cells(IC50=0.8nMand32nM,respectively)[1].NOD1antagonist-2(compound66,0.1,1μM)markedlyinhibitstheincreasesinp-RIP2,p-p65,p-p38,andp-JNKofbothTHP-1cellsandmBMDMs,demonstratingitsefficacyinmodulatingNOD1-inducedsignalingpathways[1].體內(nèi)研究NOD1antagonist-2(compound66,orally)inhibitstheexpressionofinflammatorycytokines(IL-6,TNF-α)andchemokines(CXCL1,CXCL8)inimmuneandepithelialcells,aswellasinflammatorycytokines(KC,IL-6)inaH.pylori-inducedmurinemodel[1].REFERENCES[1].XinhuaLiu,etal.SelectivelyAntagonizingtheNOD1-MediatedInflammatorySignalingPathwayMitigatestheGastricInflammationInducedbyHelicobacterpyloriInfection.JMedChem.2024Dec26;67(24):22145-22167.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792a