造血干細(xì)胞采集前后親緣及非親緣供者心理健康狀態(tài)比較.doc

造血干細(xì)胞采集前后親緣及非親緣供者心理健康狀態(tài)比較侯艷紅1，趙淑燕2，齊秦甲子1，劉麗輝2，陳曉菲1，施 兵2，朱 玲3，徐 晨4，賈瑞銘5，王蔚蔚5，楊 靜6，梁永清7，譚 亦7，李福興7，葉麗萍2解放軍第三九醫(yī)院，1心理科，2移植研究所血液科，北京市 100091；3解放軍空軍總醫(yī)院血液科，北京市 100036；4解放軍第三七醫(yī)院移植科，北京市 100071；5 61330部隊(duì)衛(wèi)生隊(duì)，河南省焦作市 453000；6總參陸航部門診部，北京市 100012；7中國(guó)造血干細(xì)胞捐獻(xiàn)者資料庫(kù)北京管理中心，北京市 100073Mental health status of relative donors versus unrelated donors before and after hematopoietic stem cell collectionHou Yan-hong1, Zhao Shu-yan2, Qi Qinjiazi1, Liu Li-hui2, Chen Xiao-fei1, Shi Bing2, Zhu Ling3, Xu Chen4, Jia Rui-ming5, Wang Wei-wei5, Yang Jing6, Liang Yong-qing7, Tan Yi7, Li Fu-xing7, Ye Li-ping21 Department of Psychology, the 309th Hospital of Chinese PLA, Beijing 100091, China; 2 Department of Hematology, Organ Transplantation Institue, the 309th Hospital of Chinese PLA, Beijing 100091, China; 3 Department of Hematology, Air Force General Hospital of PLA, Beijing 100036, China; 4 Department of Transplantation, the 307th Hospital of Chinese PLA, Beijing 100071, China; 5 Medical Team, Troops 61330 of Chinese PLA, Jiaozuo 453000, Henan Province, China; 6 Outpatient Department, Air and Land Office, Headquarters of the General staff of the PLA, Beijing 100012, China; 7 Beijing Marrow Donor Program, Beijing 100073, China摘要 背景：目前造血干細(xì)胞移植主要依靠在非血緣關(guān)系供者中尋找相合者。非親緣造血干細(xì)胞捐獻(xiàn)者的心理狀態(tài)對(duì)于保證順利完成移植，使受者得到有效治療非常重要。目的：比較親緣及非親緣供者造血干細(xì)胞采集前后心理及生理健康狀態(tài)。方法：分別在入院時(shí)，采集前(1 d)，采集后(一兩天)，1個(gè)月后回訪4個(gè)時(shí)間點(diǎn)對(duì)親緣與非親緣供者的心理狀態(tài)(SCL-90癥狀自評(píng)量表評(píng)分)及一般生理指標(biāo)(體溫，呼吸，脈搏，血壓)進(jìn)行評(píng)估比較。結(jié)果與結(jié)論：在入院時(shí)，親緣與非親緣供者的心理健康水平差異無(wú)顯著性意義(P 0.05)；而在采集前、采集后，非親緣供者的SCL-90總分、強(qiáng)迫、抑郁、焦慮、敵對(duì)、恐懼分值高于親緣供者(P 0.05)。非親緣和親緣供者的生理指標(biāo)平穩(wěn)，但在采集前和采集后2個(gè)時(shí)間點(diǎn)，兩組供者呼吸和收縮壓差異有顯著性意義。提示非親緣供者在采集過(guò)程中的心理負(fù)荷較高，應(yīng)給予針對(duì)性情緒疏導(dǎo)指導(dǎo)和心理防護(hù)。中國(guó)組織工程研究雜志出版內(nèi)容重點(diǎn)：干細(xì)胞；骨髓干細(xì)胞；造血干細(xì)胞；脂肪干細(xì)胞；腫瘤干細(xì)胞；胚胎干細(xì)胞；臍帶臍血干細(xì)胞；干細(xì)胞誘導(dǎo)；干細(xì)胞分化；組織工程全文鏈接：窗體頂端關(guān)鍵詞 ： 干細(xì)胞； 移植； 造血干細(xì)胞移植； 非親緣； 親緣； 供者； 情緒； 心理； 恐懼； 焦慮； 抑郁； Abstract： BACKGROUND: Currently, hematopoietic stem cell transplantation mainly depends on unrelated donors. Mental state of the unrelated donors is very important to ensure the successful cell transplantation. OBJECTIVE: To compare mental and physical health status of relative and unrelated donors during the hematopoietic stem cell collection. METHODS: We compared the mental (Symptom Checklist-90) and physical (temperature, breath, pulse, and blood pressure) health status of relative and unrelated donors at admission, 1 day before cell collection, and 1-2 days after cell collection. RESULTS AND CONCLUSION: At admission, there was no difference in the mental health status of relative and unrelated donors (P 0.05), while the scores on Symptom Checklist-90 were significantly higher in the unrelated donors than the relative donors, including total score, forced, depression, anxiety, hostility, and fear (P 0.05). The physical signs were steady in the unrelated and relative donors, but the difference in breath and systolic blood pressure was of great significance before and after cell collection in the two groups. These findings indicate that during cell collection, the unrelated donors exhibit heavier mental load than the relative donors, and psychological counseling and health guidance are necessary.中國(guó)組織工程研究雜志出版內(nèi)容重點(diǎn)：干細(xì)胞；骨髓干細(xì)胞；造血干細(xì)胞；脂肪干細(xì)胞；腫瘤干細(xì)胞；胚胎干細(xì)胞；臍帶臍血干細(xì)胞；干細(xì)胞誘導(dǎo)；干細(xì)胞分化；組織工程全文鏈接：Key words： hematopoietic stem cell transplantation; stress, psychological; fear; anxiety; 窗體底端 中圖分類號(hào):R394.2 基金資助: 中國(guó)造血干細(xì)胞捐獻(xiàn)者資料庫(kù)北京管理中心資助項(xiàng)目(PXM2011_077203_113500)通訊作者: 葉麗萍，副主任醫(yī)師，解放軍第三九醫(yī)院移植研究所血液科，北京市 100091 作者簡(jiǎn)介: 侯艷紅，女，1975年生，山西省交城縣人，漢族，2007年解放軍第四軍醫(yī)大學(xué)畢業(yè)，博士，副主任醫(yī)師，主要從事醫(yī)學(xué)心理學(xué)研究。引用本文: 侯艷紅,趙淑燕,齊秦甲子等. 造血干細(xì)胞采集前后親緣及非親緣供者心理健康狀態(tài)比較J. 中國(guó)組織工程研究, 2014, 18(28): 4524-4529. Hou Yan-hong,Zhao Shu-yan,Qi Qinjiazi et al. Ment