可降解聚合物在骨組織工程中的應(yīng)用進(jìn)展.doc

(extracellularmatrix,ECM)ECMECM 1290%- ()() 1 (polylacticacid,PLA)(polyglycolicacid,PGA)(polyphophazenes)(polyorthoester,POE)(polycaprolactone,PCL)(polyesterurethane)poly(anhydride-co-imides)(polyhydroxyrate,PHB) !-empirenews.page-1.1 PLAPGA-PLA(PDLAPLLAPDLLA)PGAPLAPGA(FDA)Vacanti3PGAPLAPLAPGA PLAPGA Breitbart4PGA15mm2mm15mm412Ishaug5PLGA77150300m(370160)mPLAPGA PLAPGA 1.1.1PLAPGAMikos67PGA+PLAHubble8 1.1.2PLAPGA8%9Lam10PLA20ku(1Da=0.9921u)PLA pH11pH12-8 !-empirenews.page-1.1.3PGADevin13(hydroxyapatile,HA)5050pLGAHA50%HA1459MPaHA293MPaHA10%HA650%HAPLGAPLGA1234 1.1.4PLAPGA14 1.2 (polyhydroxybutyrate,PHB)Lemoigne(1964)PHB3-PHBPHBPHB (polyhydroxyvalerate,PHV)PHBPHBVPHB024%PHVPHBPHBVPHBPHBVRivard15PHB/9%HVPHBV21PHBV 1.3 Allcockpoly(organo)phosphazenes Laurencin16165m121 1.4 !-empirenews.page- Attawia171816-MC3T3-E12416-21 2 2.1 30%ECM 1Basle19Saos-211(alkalinephosphatase,ALP)(osteopontin,OPN)20Green21CNa+/H+pH Mizuno22 () 2.2 Sims1412 !-empirenews.page- 2.3 N-() Klokkevold233.5105/ml200ml2mg/ml14(6.21.2)/(3.60.6)/241234 25 2.4 D-mannuronateL-guluronate500mmol/L4% !-empirenews.page-Paige26PLAPGA 3 3.1 27 ECM-(Integrin)ECMIntegrin14812345v61351(fibronectin,FN)FN-(Arg-Gly-Asp,RGD)28211()-(Asp-Gly-Glu-Ala,DGEA)29IntegrinECM- FNRGDDGEAGarcia30FNFNFNRGDFNFNRGD FNDee31-(Lys-Arg-Ser-Arg)Integrin 3.2 ()32 !