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1、一、翻譯(共20分,每題1分)。1 Octane2 Sodium3 Hydrogen4 Glutamic acid5 Lysine6 Acetone7 Ethyl acetate8 Sodium hydroxide9 Sodium bicarbonate10 Benzene11 丙烷12 丁醇13 腺嘌呤14 胞嘧啶15 溴16 碘17 精氨酸18 脯氨酸19 酰胺20 CaCO3答案:1 辛烷2 鈉3 氫4 谷氨酸5 賴氨酸6 酮7 酯8 氫氧化鈉9 碳酸氫鈉10 苯11 Propane12 Butanol13 Adenine14 Cytosine15 Bromine16 Iodine17
2、Arginine18 Proline19 Amide20 Calcium carbonate二、寫出下列縮寫的英文全稱并翻譯(共10分,每題2分)。1 CGMP: 2 COS (CEP): 3 SFDA: 4 WHO: 5 EU:答案: 1 Current Good Manufacturing Practice 現(xiàn)行藥品生產(chǎn)和質量管理規(guī)范2 Certificate of Suitability to Monographs of the European Pharmacopoeia歐洲藥典適用性證書3 State Food and Drug Administration (中國)食品藥品監(jiān)督管理
3、局4 World Health Organization 世界衛(wèi)生組織5 European Union 歐洲聯(lián)盟三、判斷(共16分,每題2分),并用 表示。1 ( )The discipline of analytical chemistry consists of selective analysis and specific analysis.2 ( )The present trend is mass screening of huge libraries containing several thousand molecules. This was made possible by t
4、he association of combinational chemistry with HTS.3 ( )modification and improvement of existing active molecules is a type of search for new lead compound.4 ( )The oxygen transporting capacity of the hemoglobin molecule,for example,is absolutely dependent on four iron ions that make up only 3% of i
5、ts mass.5 ( )If a long duration of action is desirable, one may administer a drug continuously or administer a drug in a long-acting form.6 ( )Low concentrations of surfactants higher the surface tension and decrease the rate of drug dissolution.7 ( )In identifying a plant constituent ,once it has b
6、een isolated and purified ,it is necessary first to determine the class of compound and then to find out which particular substance it is within that class.8 ( )Analytical chemists work to improve the reliability of existing techniques to meet the demands for better chemical measurements which arise
7、 constantly in our society.答案: 1 2 3 4 5 6 7 8 四、單選題(共14分,每題2分)。1 Analytical chemistry provides the methods and C needed for insight into our material worldA improvements B arrangements C tools D choices2 The present trend is mass screening of huge libraries containing several thousand molecules. Th
8、is was made possible by the association of C with HTS.A phytochemistry B biochemistryC combinational chemistry D medicinal chemistry3 A and ketones have carbonyl groups A aldehydes B carboxylic C alcohols D amines4 If a long duration of action is desirable, one may administer a drug continuously A a
9、dminister a drug in a long-acting form.A or B and C besides D between5 The dissolved drug in A diffuses to the bulk of the solvent from regions of high drug concentration to regions of low drug concentration.A the saturated solution B the unsaturated solutionC the aqueous solution D the salt solutio
10、n6 In UV only traces of the material are required, since the standard spectrophotometric cell only hold ? of solution and, using special cells, only one tenth of this volume need be available for spectrophotometry.A 2mL B 4mL C 5mL D 3mL7 D analysis deals with the identification of elements, ions, o
11、r compounds present in a sample (we may be interested in whether only a given substance is present)A Quantitative B Selective C Specific D Qualitative答案: 1 C 2 C 3 A 4 A 5 A 6 ? 7 D五、英譯漢(共25分,每題5分)。1 The trace elements represent a miniscule fraction of the weight of the human body, but all essential
12、 to life, usually because they are essential to the function of specific proteins, including enzymes.答案: 微量元素的代表了人體重量的微乎其微的部分,但對生命很重要,通常是因為它們是必不可少的特殊蛋白質,包括酶的功能。2 In order to design a drug product that deliver the active drug in the most bioavailable form, the pharmacist must consider (1) the type of
13、 drug product (e.g. solution, suspension, suppository); (2) the nature of the excipients in the drug products; (3) the physicochemical properties of the drug molecule.答案: 為了設計一種使活性藥物最有效的藥物產(chǎn)品,藥劑師必須考慮到 1 藥品的劑型(例如,溶液劑、懸浮劑、栓劑)2 藥品中輔料的性質 3 藥物分子的物理化學性質。3 Drag design aims to improve the desirable effects o
14、f the lead compound and to remove the undesirable effects.答案: 藥物設計旨在提高先導化合物的可取作用,去除先導化合物的副作用。4 Research programs based on the exploitation of clinical observations of side effects are of great interest in the discovery of new tracks in as they are based on information about activities observed direc
15、tly in man and not in animals.答案: 由于這些信息是直接通過觀察臨床患者得來的,而不是來自動物實驗的信息,因而,對藥物副作用的臨床觀察是藥物新的活性研究的有效方式。5 By being cognizant of these pharmacologic principles, and by remaining vigilant to countless interaction between drug and ailing body, one can substantially reduce the side effects of numerous drugs.答案
16、: 只要充分認識并運用這些藥理學原理,并對藥物和人體之間無數(shù)相互作用保持高度警惕,我們就能大大減少許多藥物的副作用。六、問答題(共15分,每題5分)。1 What is Pharmacokinetic in medicine?答案: Pharmacokinetic principles, which deal with the fate of drugs, discuss the absorption, binding, biotransformation and excretion of drugs and their metabolites in the body.2 What is the selective reaction or test?答案: A selective reaction or test is one that can occur with other substances but exhibits a degree of preference for the substance of interest.3 what distinction should be made bet
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