CD白細胞分化抗原細胞膜表面分化抗原群地定義及意義

1、標(biāo)準(zhǔn)實用文案CD/ 白細胞分化抗原/ 細胞膜表面分化抗原群的定義及意義CD （Cluster of differentiation）就是細胞膜表面的分化抗原群/ 分化抗原簇，應(yīng)用聚類分析，可將來自不同實驗室識別同一分化抗原的單克隆抗體歸為一個CD ，經(jīng)由從 1982 年第 1 次國際上人類白細胞分化抗原會議（The HumanLeucocyte Differentiation Antigen workshop，HLDA ）統(tǒng)一命名。迄今為至，人 CD 的序號已從 CD1 命名至 CD350(2009 年)，可大致劃分為 T 細胞、 B 細胞、髓細胞、 NK 細胞、血小板、粘附分子、內(nèi)皮細胞、細

2、胞因子受體、激活抗原、碳水化合物半抗原、樹突狀細胞、干細胞祖細胞、基質(zhì)細胞和紅細胞14 個組。白細胞分化抗原（ LeucocyteDifferentiation Antigen，LDA ）是指不同譜系 (1ineage) 血細胞在正常分化，成熟，活化過程中出現(xiàn)或消失的細胞表面標(biāo)志，多是跨膜蛋白或糖蛋白，少數(shù)為碳水化合物半抗原。隨著人類功能基因組計劃研究以及免疫學(xué)與其他學(xué)科的交叉，人類白細胞分化抗原的概念逐漸被人類細胞分化分子(HCDM) 所替代。采用單克隆抗體鑒定方法識別的白細胞分化抗原又稱CD （cluster of differentiation） 抗原。 檢測 CD 抗原是實驗室識別細胞

3、及不同分化階段細胞或細胞亞群最主要的方法。白細胞分化抗原（狹義上的CD）參與機體重要的生理和病理過程：免疫應(yīng)答過程中免疫細胞的相互識別，免疫細胞抗原識別、活化、增殖和分化，免疫效應(yīng)功能的發(fā)揮；造血細胞的分化和造血過程的調(diào)控；參與炎癥反應(yīng)、血栓形成和組織修復(fù)；參與細胞的生長、分化、遷移，及腫瘤的惡化和轉(zhuǎn)移。CD 在基礎(chǔ)免疫學(xué)研究中主要應(yīng)用于：CD 抗原的基因克隆， 新 CD 抗原及新配體的發(fā)現(xiàn)； CD 抗原結(jié)構(gòu)與功能關(guān)系；細胞激活途徑和膜信號的傳導(dǎo)；細胞分化過程中的調(diào)控；細胞亞群的功能。CD 在臨床免疫學(xué)研究中主要用于：機體免疫功能的檢測；白血病、淋巴瘤免疫分型；免疫毒素用于腫瘤治療、骨髓移植以

4、及移植排斥反應(yīng)的防治；體內(nèi)免疫調(diào)節(jié)治療。在許多場合下， 抗體及其識別的相應(yīng)抗原都用同一個CD 序號，因此在參閱教科書和文獻時需加注意：(1)CD 是流水編號， CD129 暫缺； CD67 和 CD66b 是重復(fù)的； CD187-190 ，CD211 ，CD237 ，CD341-343 ，CD345-248暫未編號。(2)CD 中帶有 w 的抗原或抗體 CDw12 ，CDw198 ，CDw199 ，CDw293 尚需繼續(xù)進行全面鑒定。 (3) 有些 CD 抗原又可進一步劃分為不同的成員， 一般用小寫英文字母表示， 但情況有所不同： 如 CD1 可分為 CD1a ，CD1b 和 CD1c ，文檔

5、標(biāo)準(zhǔn)實用文案這三種不同分子是分別由三個不同的高度同源的基因所編碼；CD45 至少可分為 CD45RA ，CD45RB ，CD45RC 和CD45RO ，它們是同一基因的不同異型/ 同種型（isoform ）；CD2 和 CD2R 是識別同一個分子上不同的表位； CD49已進一步劃分為CD49a ， D49b ，CD49c ， CD49d ，CD49e 和 CD49f ，它們的基因定位于不同的染色體上，但具有較高的同源性。（ 4 ）CD 的組劃分的特異性是相對的，實際上，許多CD 抗原的組織細胞分布較為廣泛。此外，有的CD抗原可由不同的分類角度而歸入不同的組，如IL-2 受體 a 鏈 CD25

6、是活化 T 細胞的標(biāo)記，也屬于細胞因子受體；再如某些屬于 T 細胞、 B 細胞、髓細胞或 NK 細胞組的 CD 抗原實際上也是粘附分子，等等。CD主要抗原表達 (Main Antigen Expression)/其他名字 / 分子量 (kDa)CD1a Cortical Thymocytes (stg), B cell subset, Dendritic cells, Langerhans cells 49,12CD1b Cortical Thymocytes (mod), B cell subset, Dendritic cells, Langerhans cells 45,12CD1c C

7、ortical Thymocytes (weak), B cell subset, Dendritic cells, Langerhans cells 43,12CD2T cells, NK cells LFA-2, E-Rosette Receptor 50CD2R Activated T cells 50CD3 T cells 16,20,25-28CD4 Helper-inducer T cells, Monocytes, Macrophages 56CD5 T cells, B cell subset 67CD6 T cells, B cell subset 105CD7 T cell

8、s 40CD8 Cytotoxic/Suppressor T cells, NK cells 32-34CD9 Platelets, Monocytes, Pre-B cells 24CD10 Pre-B cells, Granulocytes CALLA 100CD11a Leukocytes LFA-1,L Integrin 180CD11b Granulocytes, Monocytes, NK cells MAC-1,M Integrin, CR3 170文檔標(biāo)準(zhǔn)實用文案CD11c Granulocytes, Monocytes, NK cells, T cell subset, B

9、cell subset,CDw12 Granulocytes, Monocytes 90-120CD13 Granulocytes, Monocytes Aminopeptidase N 130CD14 Monocytes 55CD15 Granulocytes, Monocytes Lewis X CHOCD15s Neutrophils Sialyl Lewis X CHOCD15u Myeloid subset Sulfated Lewis X CHOCD16a NK cells, Macrophages FcRIII A 50-65CD16b Granulocytes FcRIII B

10、 48CD17 Granulocytes, Monocytes, Platelets Lactosylceramide -CD18 Leukocytes (Platelets negative)2 Integrin 95CD19 B cells 90CD20 B cells 33,35,37CD21 B cells subset, Follicular dendritic cells CR2 145CD22 B cells 140CD23 B cell subset, Eosinophils, Platelets FcRII 50-45CD24 B cells, Granulocytes 41

11、/38CD25 Activated T cells IL-2R Chain 55CD26 T cell subset, Macrophages 110CD27 T cell subset 55CD28 T cell subset 44CD29 Leukocytes1 Integrin 130X Integrin 150文檔標(biāo)準(zhǔn)實用文案CD30 Activated T and B cells, Reed Sternberg cells Ki-1 105CD31 Platelets, Monocytes, Granulocytes, B cells PECAM-1, GPIIa 140CD32 M

12、onocytes, Neutrophils, B cells, Eosinophils FcRII 40CD33 Myeloid Progenitor cells, Monocytes 67CD34 Hematopoietic Progenitor cells 105-120CD35 Monocytes, B cells, Granulocytes CR1 160,190,220,250CD36 Monocytes, Platelets GPIV (IIIb) 88CD37 B cells 52-40CD38 Activated T cells, Plasma cells 45CD39 B c

13、ells, Monocytes 100-70CD40 B cells, Monocytes, Carcinoma cells 48/44CD41 Platelets, Megakaryocytes GPIIb/IIIa,IIb Integrin 120CD42a Platelets, Megakaryocytes GPIX 23CD42b Platelets, Megakaryocytes GPIB-a 135,23CD42c Platelets, Megakaryocytes GPIB-b 22CD42d Platelets, Megakaryocytes GPV 85CD43 T cell

14、s, Granulocytes, MonocytesLeukosialin 90-100CD44 Leukocytes, Erythrocytes H-CAM, Pgp-1 8-90CD44R (Varied-dependent upon Exon Splicing)CD45 Leukocytes Leukocyte Common Antigen 180,190,205,220CD45RA B cells, T cell subset, Monocytes 220,205CD45RB B cells, T cell subset, Monocytes 190,205,220文檔標(biāo)準(zhǔn)實用文案CD

15、45RC B cells, T cell subset 190,205,220CD45RO B cells, T cell subset, Monocytes 180CD46 Ubiquitous (Erythrocytes negative) Membrane Cofactor Protein 66,56CD47 Ubiquitous 47-52CD47R Broad 47-52CD48 Leukocytes 43CD49a Activated T cells VLA-1,1 Integrin 210CD49b B cells, Monocytes, Platelets VLA-2,2 In

16、tegrin 160CD49c B cells VLA-3,3 Integrin 125CD49d Lymphocytes, Monocytes, Eosinophils VLA-4,4 Integrin 150,80,70CD49e T cell subset, Monocytes, Platelets VLA-5,5 Integrin 132/25CD49f T cell subset, Monocytes VLA-6,6 Integrin 120/25CD50 Leukocytes ICAM-3 124CD51 PlateletsV Integrin 125/25CD51/61 Plat

17、elets, Osteoclasts, Endothelial cells complexCD52 Leukocytes CAMPATH-1 21-28CD53 Leukocytes 32-40CD54 Endothelial cells, Various activated cells ICAM-1 90CD55 Broad Decay Accelerating Factor 75CD56 NK cells N-CAM 220/135CD57 NK cells, T cell subset HNK-1 110CD58 Broad LFA-3 65-70文檔標(biāo)準(zhǔn)實用文案CD59 BroadPr

18、otectin, Homologous Restriction Factor 18-20CD60a T cell subset, platelets GD3CHOCD60b T cell subset, activated B cells 9-0-sialyl GD3CHOCD60c T cell subset 7-0-sialyl GD3CHOCD61 Platelets, Megakaryocytes3 Integrin, GPIIIa 110CD62E Endothelial cells E-Selectin, ELAM-1 140CD62L Lymphocytes, Monocytes

19、, NK cells L-Selectin, LECAM-1 150CD62P Activated Platelets, Endothelial cells P-Selectin, LECAM-3 75-80CD63 Activated Platelets, Monocytes 53CD64 Monocytes FcRI 75CD65 NeutrophilsCD65s Neutrophils, MonocytesCD66a Neutrophils Biliary Glycoprotein 160-180CD66b Granulocytes CGM6 95-100CD66c Neutrophil

20、s, Colon carcinoma NCA 90CD66d Neutrophils CGM1 30CD66e Colon epithelial CEA 180-200CD66f Pregnancy Specific GlycoproteinCD67 (Re-assigned to CD66b) (重復(fù) CD66b)CD68 Monocytes, Macrophages 110CD69 Activated T and B cells, NK cells Activation Inducer Molecule 34/28CD70 Activated T and B cells, Reed-Ste

21、rnberg cells 75,95,170文檔標(biāo)準(zhǔn)實用文案CD71 Proliferating cells Transferrin Receptor 95CD72 B cells 43/39CD73 B & T cell subset ECTO-5 Nucleotidase 69CD74 B cells, Monocytes Invariant Chain 41,35,33CD75 B cell subset, Epithelial Lactosamines CHOCD75s B cell subset-2, 6-sialylated Lactosamines CHOCD77 Activat

22、ed B cells, Endothelial cellsCD79a B cells MB-1 33,40CD79b B cells B29 33,40CD80 Activated B cells B7-1 60CD81 B cells, T cells, Neutrophils TAPA-1 22CD82 Leukocytes, Platelets 50-53CD83 Dendritic cells, Activated lymphocytes HB15 43CD84 Monocytes, Platelets, B cells 73CD85 Dendritic cells, Monocyte

23、s, B cells see note 1 in notes section 110CD86 Monocytes, Activated B cells B7-2 80CD87 Granulocytes, Monocytes, Activated T cells UPA Receptor 50-65CD88 Granulocytes C5a Receptor 42CD89 Neutrophils, Monocytes Fc Receptor 55-70CD90 Progenitor cell subset, Thymic Stromal cells THY-1 18CD91 Monocytes2

24、 Macroglobulin Receptor 600CD92 Neutrophils, Monocytes, Platelets, Endothelial cells 70文檔標(biāo)準(zhǔn)實用文案CD93 Neutrophils, Monocytes, Endothelial cells 120CD94 NK cells, T cell subset 30CD95 Apoptotic cells FAS 42CD96 Activated T cells Tactile 160CD97 Activated T cells CD55 Ligand 74,80,89CD98 Monocytes, T ce

25、lls, B cells 4F2 80,40CD99 Lymphocytes, Thymocytes 32CD99R T cells, NK cells, Myeloid cells 32CD100 Broad 150CD101 Granulocytes, Monocytes, Activated T cells 140CD102 Lymphocytes, Monocytes ICAM-2 60CD103 Intra Epithelial Lymphocytes HML-1,E Integrin 150,25CD104 Epithelial, Schwann cells4 Integrin 2

26、20CD105 Endothelial cells Endoglin 95CD106 Activated Endothelial cells VCAM-1 100-110CD107a Activated Platelets LAMP-1 110CD107b Activated Platelets LAMP-2 120CD108 Activated splenic T cells 80CD109 Activated T cells, Platelets, Endothelial cells Platelet Activation Factor 170/150CD110Stem cell subs

27、et,Megakaryocytes,Platelets (v. weak) Thrombopoietin Receptor, Mpl 82-84CD111 Stem cell subset, Macrophages, Neutrophils PRR/Nectin-1 64-72CD112 Monocytes, Neutrophils, Stem cell subset PRR2/Nectin-2 64-72文檔標(biāo)準(zhǔn)實用文案CD113 Epithelial cells, Placenta PRR3, Nectin-3 83CD114 Granulocytes, Monocytes G-CSF R

28、eceptor 95,139CD115 Monocytes, Macrophages M-CSF Receptor 150CD116 Monocytes, Neutrophils, Eosinophils GM-CSF ReceptorChain 60CD117 Progenitor cells SCF-Receptor, c-kit 145CD118 Epithelial cells LIF Receptor 190CD119 Monocytes, B cells, Epithelial cells IFNReceptor 90CD120a Monocytes, Granulocytes T

29、NF Receptor, Type 1 55CD120b Monocytes, Granulocytes, TNF Receptor, Type 2 75Activated lymphocytesCD121a T cells, Fibroblasts, Endothelial cells IL-1 Receptor, Type 1 80CD121b B cells, Monocytes, Macrophages IL-1 Receptor, Type 2 68CD122 T cell subset, NK cells IL-2 Receptor Chain 75CD123 Progenitor

30、 cells, Granulocytes, Monocytes, Megakaryocytes, IL-3 Receptor Chain 70CD124 B cells, T cells, Progenitor cells IL-4/IL-13 Receptor 140CD125 Eosinophils, Basophils IL-5 Receptor Chain 60CD126 Plasma cells, Activated B cells IL-6 Receptor Chain 80CD127 Early B cells, T cells, Progenitor cells, Monocy

31、tes, IL-7 Receptor Chain 65-75CD129 Not assignedCD130 Plasma cells, Activated B cellsgp130Receptor Subunit for IL-6,IL-11,LIF, OSM,LNTF,CT-1130CD131 Myeloid cells Common Chain for IL-3, IL-5, GM-CSF Receptor120文檔標(biāo)準(zhǔn)實用文案CD132 BroadCommon Chain for IL-2, IL-4, IL-7, IL-9, IL-15 ReceptorsCD133 Stem cell

32、 subset AC-133 120CD134 Activated T cell subset OX40 48-50CD135 Progenitor cell subset Flt3/FIk2 130-150CD136 Epithelial cells Macrophage Stimulating Protein Receptor 180CD137 T cell subset 4-1BB 30CD138 Plasma cells, Epithelial cells SYNDECAN-1 20CD139 Germinal center B cells 209,228CD140a(Undetect

33、able on most normal cells) PDGF Receptor 180CD140bEndothelial cell subset, Stromal cells PDGF Receptor 180CD141 Endothelial cells Thrombomodulin 100CD142 Activated Monocytes and Endothelial cells Tissue Factor 45CD143 Endothelial cell subset Angiotensin Converting Enzyme 170CD144 Endothelial cells V

34、E-CADHERIN 135CDw145 Endothelial cells, Some stromal cells 25,90,110CD146 Endothelial cells, Activated T cells MUC18/S-endo 118CD147 Endothelial cells, Monocytes, T cell subset, Platelets, Erythrocytes,50-60CD148 Hematopoietic cells HPTP-ETA/DEP-1CD150 T cell subset, B cell subset, Thymocytes SLAM 7

35、0CD151 Platelets, Endothelial cells PETA-3 27CD152 Activated T cells CTLA-4 4464Neurothelin/Basigin文檔標(biāo)準(zhǔn)實用文案CD153 Activated T cells CD30 Ligand 40CD154 Activated T cells, Mast cells, Basophils CD40 Ligand 33CD155 Monocytes, Macrophages, Thymocytes Poliovirus Receptor 80-90CD156a Monocytes, Macrophage

36、s, Granulocytes ADAM8 60CD156b Broad TACE/ADAM17 85CD156c Broad ADAM-10 98CD157 Monocytes, Neutrophils, Endothelial cells BST-1 42-45CD158 T cell subset, NK cell subset see note 2 in notes sectionCD158a NK cells, T cell subset p58.1, P50.1 50,58CD158b NK cells, T cell subset p58.2, p50-2 50,58CD159a

37、 NK cells NKG2a 43CD159c NK cells NKG2C 40CD160 T cell subset, NK cell subset By55 26CD161 NK cells, T cell subset NKR-P1 60CD162 T cells, Monocytes, Granulocytes, B cell subset PSGL-1 110CD162R NK cell subset PEN5 CHOCD163 Monocytes KiM4 130CD164 T cells, Monocytes, Granulocytes, B cell subset, Pro

38、genitor cellsMGC-24 80CD165 Thymocytes, Thymic epithelial cells AD2/gp37 37CD166 Activated Lymphocytes, Endothelial cells, Fibroblasts ALCAM, CD6 Ligand 100CD167a Epithelial cells, MyoblastsDiscoidin Domain Receptor, DDR1 120CD168 Thymocyte subset, T cell subset, Monocytes RHAMM 84-88文檔標(biāo)準(zhǔn)實用文案CD169 M

39、acrophage subset Sialoadhesin 185CD170 Macrophage subset, Neutrophils Siglec-5 140CD171 Monocytes, T cell subset, B cells L1 200CD172a Monocytes, T cell subset, Stem cells SIRP 110CD172b Monocytes, Dendritic cells SIRP1 50CD172g T cells, Activated NK cells SIRP, SIRP 2 45-50CD173 Red cells, Stem cel

40、l subset, Platelets Blood group H type 2 CHOCD174 Stem cell subset, Epithelial cells Lewis Y CHOCD175 Stem cell subset TN CHOCD175s Erythroblasts Sialyl-Tn CHOCD176 Stem cell subset Thomson-Friedrenreich antigen CHOCD177 Neutrophil subset NB1 56-62CD178 Activated T cells Fas ligand 38-42CD179a Pro-B

41、 cells, Pre-B cells V pre beta 16CD179b Pro-B cells, Pre-B cells Lambda 5 22CD180 B cell subset, Monocytes, Dendritic cells Rp105/Bgp 95 95-105CD181 Neutrophils, T cell subset CXCR1 39CD182 Monocytes, Granulocytes, T cell subset CXCR2 40CD183 Activated T cells, Activated NK cells CXCR3 40CD184 T cel

42、l subset, B cells, Monocytes, Dendritic cells, Endothelial cells,CXCR4 45CD185 B cells, T cell subset CXCR5 45CD186 T cell subset CXCR6, BONZO 40文檔標(biāo)準(zhǔn)實用文案CD191 T cells, Monocytes, Stem cell subset CCR1 39CD192 Monocytes, T cell subset, B cells, Basophils, Endothelial cells， CCR2 40CD193 Eosinophils,

43、Basophils, T cell subset, Dendritic cell subset， CCR3 45CD194 T cells, Bascphils, Platelets, Monocytes (low) CCR4 41CD195 Monocytes, T cell subset CCR5 45CD196 T cell subset, B cells, Dendritic cell subset CCR6 45CD197 T cell subset CCR7 45CDw198 T cell subset, Monocytes CCR8 50CDw199 T cell subset

44、CCR9 50CD200 Thymocytes, B cells, Endothelium, Activated T cells OX-2 45-50CD201 Endothelial cell subset Endothelial cell Protein C Receptor(EPCR) 50CD202b Endothelial cells, Stem cells Tie/Tek 150CD203c Basophils, Megakaryocytes NPP3 130-150CD204 Macrophages Macrophage Scavenger Receptor 220CD205 D

45、endritic cells, Thymic epithelium DEC-205 205CD206 Dendritic cell subset, Macrophages, Monocytes Macrophage Mannose Receptor 180CD207 Immature langerhans cells Langerin 40CD208 Interdigitating dendritic cells DC-LAMP 70-90CD209 Dendritic cell subset DC-SIGN 44CDw210 T cells, B cells, NK cells, Monoc

46、ytes, Macrophages IL-10R 90-110CD212 Activated T cells, Activated NK cells IL-12R1 100CD213a1 B cells, Monocytes, Fibroblasts, Endothelial cells IL-13R1 65文檔標(biāo)準(zhǔn)實用文案CD213a2 B cells, Monocytes IL-13R2 65CD217 Broad IL-17R 120CD218a Lymphocytes, Neutrophils, Dendritic cell subset IL-18R 70CD218b Lymphoc

47、ytes, Neutrophils, Dendritic cell subset IL-18R 70CD220 BroadInsulin Receptor 140 + 70CD221 BroadIGF-1Receptor 140 + 70CD222 BroadIGF-2Receptor/ Mannose-6-phosphate Receptor 250CD223 Activated T cells, Activated NK cells LAG-3 70CD224 Leukocytes, Stem cells Gamma Glutamyl Transferase (GGT) 27, 68CD2

48、25 Broad Leu-13 17CD226 T cells, NK cells, Monocytes, Platelets DNAM-1 65CD227 Stem cell subset, Epithelial cells MUC-1 300CD228 Stem cells, Melanoma cells Melanotransferrin 80-95CD229 T cells, B cells Ly-9 95, 110CD230 Broad Prion Protein 35CD231 T cell leukemia, Neuroblastoma TALLA-1 30-45CD232 Br

49、oad VESPR (Plexin C1) 200CD233 Red cells Band 3 90CD234 Red cells Duffy 35-45CD235a Red cells Glycophorin A 36CD235b Red cells Glycophorin B 20CD236 Stem cell subset, Red cells Glycophorin C/D 32/23文檔標(biāo)準(zhǔn)實用文案CD236R Stem cell subset, Red cells Glycorphorin C 32CD238 Stem cell subset, Red cells Kell 93CD239 Stem cell subset, Red cells B-CAM, Lutheran 78-85CD240CERed cells Rhesus 30 CE 30-32CD240DRed cells Rhesus 30 D 30-32CD241 Red cells Rhesus 50 Glycoprotein 50CD242 Red cells ICAM-4 42CD243 Stem cells MDR-1 180CD244 NK cells, T cell subset 2B4 70CD245 T cell