獸醫(yī)臨床病理英PPT學(xué)習(xí)教案

1、會計學(xué)1獸醫(yī)臨床病理英獸醫(yī)臨床病理英第1頁/共116頁第2頁/共116頁第3頁/共116頁第4頁/共116頁第5頁/共116頁第6頁/共116頁第7頁/共116頁第8頁/共116頁第9頁/共116頁第10頁/共116頁第11頁/共116頁第12頁/共116頁DogsCatsTotal red blood cells(x1012/L)5.58.55.010.0Haemoglobin(g/dl)12.018.08.015.0PCV (L/L)0.370.550.260.45MCV (fl)60.077.039.055.0MCH (pg)19.524.512.517.5MCHC (g/dl)32.0

2、37.030.036.0ROUTINE HAEMATOLOGY第13頁/共116頁RBC indices are helpful in the classification of certain anemias.ROUTINE HAEMATOLOGY第14頁/共116頁ROUTINE HAEMATOLOGY第15頁/共116頁ROUTINE HAEMATOLOGY第16頁/共116頁ROUTINE HAEMATOLOGY第17頁/共116頁ROUTINE HAEMATOLOGY第18頁/共116頁第19頁/共116頁DISORDERS OF WHITE CELL NUMBER第20頁/共116

3、頁DISORDERS OF WHITE CELL NUMBER第21頁/共116頁DISORDERS OF WHITE CELL NUMBER第22頁/共116頁StressGlucocorticoid therapyHyperadrenocorticismChylothorax (loss of lymphocytes into the pleural space)Lymphangiectasia (loss of lymphocytes into the gut)Acute phase of most viral infections (e.g. canine distemper, par

4、vovirus, FeLV)Septicaemia/endotoxaemiaDISORDERS OF WHITE CELL NUMBER第23頁/共116頁DogsCats percentageAbsolute valuepercentageAbsolute value(10/Total WBCN/a617N/a5.519.5Band neutropils0300.30300.3Neutropils6077311.535372.512.5Lymphocytes123014.820551.57Monocytes3100.21.51401.5Eosinopils2100.11.321201.5ba

5、sopilsrarerarerareRareReference ranges for total and differential white blood cell counts第24頁/共116頁DISORDERS OF WHITE CELL NUMBER第25頁/共116頁DISORDERS OF WHITE CELL NUMBER第26頁/共116頁第27頁/共116頁第28頁/共116頁Electrolytes Sodium; Potassium; Chloride M a g n e s i u m ; C a l c i u m ; Phosphorus Muscle enzyme

6、s Creatine kinaseAspartate aminotransferase Carbohydrate metabolism GlucoseFructosamine Lipid metabolism CholesterolTriglycerides Miscellaneous tests Iron Lead ZincCopper Chemical profiles and test selection 第29頁/共116頁第30頁/共116頁第31頁/共116頁SERUM PROTEINS第32頁/共116頁SERUM PROTEINS第33頁/共116頁第34頁/共116頁INDI

7、CATORS OF RENAL FUNCTION第35頁/共116頁INDICATORS OF RENAL FUNCTION第36頁/共116頁INDICATORS OF RENAL FUNCTION第37頁/共116頁INDICATORS OF RENAL FUNCTION第38頁/共116頁INDICATORS OF RENAL FUNCTION第39頁/共116頁INDICATORS OF RENAL FUNCTION第40頁/共116頁MARKERS OF HEPATIC DISEASE 第41頁/共116頁MARKERS OF HEPATIC DISEASE 第42頁/共116頁MA

8、RKERS OF HEPATIC DISEASE 第43頁/共116頁MARKERS OF HEPATIC DISEASE 第44頁/共116頁MARKERS OF HEPATIC DISEASE 第45頁/共116頁MARKERS OF HEPATIC DISEASE 第46頁/共116頁MARKERS OF HEPATIC DISEASE 第47頁/共116頁MARKERS OF HEPATIC DISEASE 第48頁/共116頁MARKERS OF HEPATIC DISEASE 第49頁/共116頁MARKERS OF HEPATIC DISEASE 第50頁/共116頁MARKER

9、S OF HEPATIC DISEASE 第51頁/共116頁MARKERS OF HEPATIC DISEASE 第52頁/共116頁MARKERS OF HEPATIC DISEASE 第53頁/共116頁第54頁/共116頁PANCREATIC DISEASE第55頁/共116頁PANCREATIC DISEASE第56頁/共116頁PANCREATIC DISEASE第57頁/共116頁Glucose第58頁/共116頁Glucose第59頁/共116頁Glucose第60頁/共116頁GlucoseFigure 4.19: Causes of hypoglycaemia in the

10、 dog. Cats may rarely be affected by insulinoma.Substrate deficiency: Neonatal hypoglycaemia Juvenile hypoglycaemia H u n t i n g d o g hypoglycaemia G l y c o g e n s t o r a g e diseaseSepsis第61頁/共116頁Glucose第62頁/共116頁Glucose第63頁/共116頁第64頁/共116頁Fructosamine第65頁/共116頁Cholesterol 第66頁/共116頁第67頁/共116

11、頁第68頁/共116頁第69頁/共116頁第70頁/共116頁第71頁/共116頁第72頁/共116頁CHEMICAL PROFILES AND TEST SELECTION第73頁/共116頁TestsFBC, TP, albumin, globulin, ALT, ALP, GGT, bilirubin, amylase, urea, creatinine, glucose, urinalysisFBC， TP, albumin, globulin, ALT, ALP, bilirubin, urea, creatinine, glucoseAs health screen plus bi

12、le acids, electrolytes, cholesterol, CK, calcium, phosphorus FBC, TP, albumin, globulin, ALT, ALP, bilirubin, bile acids, CK, cholesterol, urea, creatinine, glucose, calcium, phosphorus, electrolyte screen, urinalysis (SG, dipstick and sediment examination). FBC, TP, albumin, globulin, ALT, ALP, bil

13、e acids, urea, creatinine, glucose, calcium, CK, phosphorus, magnesium, electrolyte screenPCV, TP, albumin, globulin, urea, creatinine, sodium, potassium, calcium, phosphorus, urinalysis (SG dipstick and sediment examination)TP, albumin, globulin, ALT, ALP, AST, GGT, bilirubin, bile acids, cholester

14、olIndicationsR o u t i n e screeningS c r e e n f o r existing disease prior to routine surgeryGastrointestinai.endocrine disease and nonlocalizing signsPolydipsiaS e i z u r e s , w e a k n e s s , episodic collapse Monitoring hepatotoxicity第74頁/共116頁第75頁/共116頁Fecal analysisExamination of vomitusBl

15、ood testsImaging techniquesEndoscopy第76頁/共116頁Possible diagnostic procedures for common alimentary symptoms第77頁/共116頁Possible diagnostic procedures for common alimentary symptoms第78頁/共116頁Possible diagnostic procedures for common alimentary symptoms第79頁/共116頁Possible diagnostic procedures for common

16、 alimentary symptoms第80頁/共116頁Endoscopy/biopsy Possible diagnostic procedures for common alimentary symptoms第81頁/共116頁Possible diagnostic procedures for common alimentary symptoms第82頁/共116頁Possible diagnostic procedures for common alimentary symptoms第83頁/共116頁第84頁/共116頁Symptom/SignSmall intestineLar

17、ge intestineFaecal volumeIncreasedReducedFaecal tenesmusNonePresentFaecal bloodNone or changedOften presentFaecal mucusNoneOften presentUrgency（尿急）（尿急）RareOften presentDyschezia（排便困難）（排便困難）AbsentOften presentSteatorrhoea（脂肪痢）（脂肪?。㎡ften presentAbsentVomitingMay occurOccurs in 30% of casesWeight lossP

18、resentAbsentFlatus/borborygmi(腸鳴腸鳴)PresentRareCoat/skin conditionPoorNormalAppetiteIncreasedNormal or reduced第85頁/共116頁Viral infections: Feline panleucopenia貓瘟貓瘟 Canine parvovirus犬細(xì)小病毒犬細(xì)小病毒 Coronavirus冠狀病毒冠狀病毒Bacterial infection: Salmonellosis Campylobacter infection彎曲菌彎曲菌Intussusception腸套疊腸套疊Haemor

19、rhagic gastroenteritis第86頁/共116頁Colitis: Lymphocytic-plasmacytic Eosinophilic Histiocytic Granulomatous LymphosarcomaSystemic disease: Hyperthyroidism (cats) Hypoadrenocorticalism Hypothyroidism (dogs) Chronic renal failure Hepatic disease FeLV, FIV and FIP第87頁/共116頁第88頁/共116頁第89頁/共116頁第90頁/共116頁第91

20、頁/共116頁identified and treated whenever possible. 第92頁/共116頁第93頁/共116頁第94頁/共116頁第95頁/共116頁第96頁/共116頁 Table 9.1:Clinicopathological abnormalities associated with disturbances of hepatobiliary function. FunctionAbnormal laboratory test resultassociated with liver dysfunctionCarbohydrate metabolism:Glucose homeostasisHyper- or hypoglycaemiaLipid metabolism:CholesterolFatty acidsLipo