多發(fā)性骨髓瘤化療方案

1、化療方案骨髓瘤力殺藥物劑量用法ABVD每28k周期阿霉素225mg/mivd1,15210mg/mivd1,15長春堿6mg/n2ivd1,15達(dá)卡巴嗪2375mg/mivd1,15BACOP（*為加強(qiáng)方案）阿霉素25mg/nm(*40mg/m2)或EPIivd1,8每28k周期40mg/n2(*50mg/m)環(huán)磷酰胺2650mg/mivd1,8長春荊1堿2mivd1,8潑尼松240-60mg/mpod15-2810mg/m2ivd15,22BEACOPP（*為加強(qiáng)方案）阿霉素25mg/nm(*35mg/m)ivd1每21k周期環(huán)磷酰胺650mg/rm(*1250mg/n2)ivd1依托泊甘1

2、00mg/m(*200mg/n2)ivd1-3長春荊1堿n2(max2mg/mi)ivd8甲基平肌2100mg/mpod1-7潑尼松240mg/mpod1-14210mg/mivd8dex-DEAM卡莫司汀260mg/mivd2美法侖220mg/mivd3依托泊甘2200mg/miv,Q12hd4-7阿糖胞苜2100mg/miv,Q12hd4-7地塞米松8mgpo,tidd1-10mini-DEAM卡莫司汀260mg/mivd1美法侖230mg/m(max50mgivd5依托泊甘75mg/nmivd2-5阿糖胞苜2100mg/miv,Q12hd2-5CHOP14天或21阿霉素50mg/mi(或

3、EPI80mg/m2)ivd1周期環(huán)磷酰胺2750mg/mivd1長春荊1堿2mivd1潑尼松100mgpod1-5CHOP-E每21k周期阿霉素50mg/mi(或EPI80mg/m2)ivd1環(huán)磷酰胺2750mg/mivd1長春荊堿2mivd1依托泊甘2100mg/mivd1-3潑尼松100mgPod1-5CHOP-L-ASP每21天"周期阿霉素50mg/n2i(或EPI80mg/m2)ivd1環(huán)磷酰胺2750mg/mivd1長春荊堿2m(max2mgivd1潑尼松100mgpod1-5左旋門冬6000U/ivd1,3,7,9,酰胺酶11CEOP每21天"周期環(huán)磷酰胺25

4、00mg/miv依托泊甘2mivd1長春荊堿2mgivd1潑尼松75mg/mpod1COPd1-5每14-21k周環(huán)磷酰胺2750mg/miv期長春荊堿2m(max2mgivd1潑尼松100mgpod1,8COPPd1-5每28天"周期環(huán)磷酰胺600-800mgiv長春荊堿2m(max2mgivd1,8內(nèi)卡巴肥2100mg/mpod1,8潑尼松240mg/mpod1-14CVPd1-14每21天"周期環(huán)磷酰胺2400mg/miv長春荊堿(max2mgiivd1-5潑尼松100mgpod1DDP-VP-16d1-5每21天"周期順柏230mg/mivd1-3(水依托

5、泊甘240-50mg/miv化）DHAPd5-10每14-21k周順柏2100mg/miv期阿糖胞苜_22g/miv,Q12hd1地塞米松40mgivd2DICEd1-4每21天"周期異環(huán)磷酰1000mg/rniv胺d1-4順柏225mg/miv依托泊甘260mg/mivd1-4地塞米松26-9mg/mpod1-4EPOCHd1-10每21天"周期阿霉素210mg/miv（連續(xù)96hd1-4依托泊5050mg/n2iv(連續(xù)96h)d1-4長春新堿miv（連續(xù)96h)d1-4環(huán)磷酰胺750mg/rniv潑尼松60mg/mPod5EPOCHd1-5每21天同期依托泊甘60mg

6、/n2iv2順柏25mg/miv(連續(xù)d1-496hd1-4甲潑尼龍500mg/miiv阿糖胞苜2g/mivd1-4FCd5每28天一周期氟達(dá)拉濱25-30mg/miv環(huán)磷酰胺250-300mg/R2ivd1-3FCMd1-3每28天同期弗1遼拉浜25mg/miv米托恿釀6-8mg/mivd1-32環(huán)磷酰月女200mg/mivd1FCMd1-3每28天同期弗1遼拉浜25mg/miv米托恿釀10mg/n2ivd1-3地塞米松20mgiv/pod1GDPd1-5每21天一周期吉西他濱1000mg/miv順柏75mg/mivd1,8地塞米松40mgivd1GemOxd1-4吉西他濱1000mg/mi

7、v奧沙利柏100mg/mivd1ICEd1依托泊甘100mg/miiv異環(huán)磷酰5000mg/miv(24hd1-3胺輸注）卡伯按AUC=5max800mgivd2IVEd2母21天一周期表阿毒素50mg/miv異環(huán)磷酰3000mg/miv(22h)d1胺d1-3依托泊甘200mg/miiv(>2h)MACOP-Bd1-3母12周重復(fù)一阿毒素50mg/miv周期wk1,3,5,7環(huán)磷酰胺2350mg/miv,9,11wk1,3,5,7長春新堿2m(max2mgiv,9,11wk2,4,6,8210mg/miv,10,12潑尼松75mg/dP。wk4,8,12wk1-11后逐漸減量MIMEw

8、k2,6,10Methy-2500mg/mivguazoned1異環(huán)磷酰1000mg/rniv胺d1-5依托泊甘2100mg/miv甲氨蝶吟230mg/mivd1-3MOEPd3每21k周期米托恿釀10mgiv長春新堿2m(max2mgivd1-3依托泊甘100mgivd1潑尼松60mgpod1-5MOPPd1-5每28k周期氮芥6mg/miv長春新堿2mivd1,8內(nèi)卡巴肥2100mg/mpod1,8潑尼松240mg/mpod1-14SMILEd1-14每28k周期甲氨蝶吟2g/m2iv異環(huán)磷酰1500mg/mivd1胺d2-4依托泊甘2100mg/miv地塞米松240mg/mivd2-4L

9、-ASP6000U/mivd2-4d8,10,12,HD-MTX14,16,18,甲氨蝶吟1-3giv(12h)20HD-AraC阿糖胞苜3g/m2iv,Q12hd1ABCM阿霉素230mg/mivd1-3(6)卡莫司汀230mg/miv環(huán)磷酰胺2100mg/mpod1美法侖6mg/mpod1DCEPd22-25地塞米松40mg/dIv/pod22-25環(huán)磷酰胺2400mg/m依托泊甘240mg/m順柏210mg/mDT-PACE地塞米松40mg/d沙利度胺400mg/d阿霉素210mg/m順柏210mg/m環(huán)磷酰胺2400mg/m依托泊甘240mg/mMP每4-6周一周期美法侖210mg/m

10、潑尼松250mg/mM2美法侖8mg/n2卡莫司汀220mg/m環(huán)磷酰胺2400mg/m長春勸堿2m潑尼松40mg/nm,20mg/iPEDA順柏220mg/m依托泊甘2100mg/m地塞米松40mg/d阿糖胞苜1g/m2VAD長春勸堿2m阿霉素9mg/n2地塞米松40mgLD雷利度胺25mg/d地塞米松40mg/div,iv,iv,iv/popoIviv,持續(xù)iv,持續(xù)iv,持續(xù)popopoivivivpoivivivivivivpopoiv/po44ddd1-4d1-4d1-4維持d1-4d1-4d1-4d1-4d1-4d1-4d1-4dididid1-7,8-14d1-4d1-4d1-5

11、d5d1-4d1-4d1-4,9-12,17-20LRd1-21雷利度胺25mg/dpod1-4,9-12,17-20利妥昔單2375mg/miv抗每月L+DVDwks1-3雷利度胺10mg/dpowks2-5,13脂質(zhì)體阿240mg/miv-16霉素堿2mgivd1-21地塞米松40mg/dpod1L+MP雷利度胺5-10mg/dpodi美法侖或mpod1-4潑尼松5,10,15,20mg/dpoCTDd1-21沙利度胺2mpod1-4環(huán)磷酰胺50,100,150,200mg/dpod1-4地塞米松poMPTd1-28沙利度胺pod1-21美法侖pod1-4,15-2潑尼松po1TD沙利度胺pod1-28地塞米松pod1-7d1-7pod1-28d1-4,9-12TDD,17-20（奇沙利度胺po數(shù)周期）脂質(zhì)體阿ivd1-4（偶數(shù)霉素周期）地塞米松pod1-28TPdi沙利度胺po潑尼松pod1-4,9-12VD,17-20硼替佐米iv地塞米松ivQdQodd1,4,8,11d1-4,9-12VMP,17-20（奇硼替佐米iv數(shù)周期）d1-4（偶數(shù)美法侖iv周期）潑尼松poPDAd1,4,8,11硼替佐米iv,22,25,29阿霉素iv,32地塞