2022年先天性心臟病流行病學(xué)材料

1、Congenital heart malformation: Prevalence, severity, survival, and quality of life先天性心臟病流行病學(xué)先天性心臟病流行病學(xué)(li xn bn xu)第一頁，共十七頁。The lowest values/1000 live birthsAuthor Region Fyler 2.10 New England, USAGardiner 2.17 Toronto, CanadaAkman 3.20 Bogalusa, USAMacMahon 3.20 Birmingham, UKMckeown 4.20 Birming

2、ham, UKBosi 4.60 ItalyBierman 4.70 HawaiiPrevalence of congenital heart malformation at birth第二頁，共十七頁。the highest values/ 1000 births author Region Fischer 8.20 Tyrol,AustriaKerrebijn 8.26 Leiden , NetherlandGrech 8.80 MaltaHoffmann 8.82 San Francisco, USAMeberg 9.02 NorwayNakazawa 10.00 JapanManett

3、i 12.30 Florence, ItalyYerushalmi 11.70 California,USAPrevalence of congenital heart malformation at birth第三頁，共十七頁。The oldest surveys/ 1000 live birthsAuthor Date Prevalence () Macmahon 194049 3.23Carlgren 1941 50 6.35Harris 194450 5.90Pleydell 194457 3.20Landtman 1945 63 8.00Richards 194653 5.50Gar

4、diner 194849 2.17Mustachi 194951 5.88Prevalence of congenital heart malformation at birth第四頁，共十七頁。Recent data / 1000 live birthsAuthor Date Prevalence() Grech 1990-94 8.80Robida 1984-94 12.23Bosi 1992-93 4.60Anderson 1987-90 10.20Cerboni 1988-90 6.08Ferencz 1981-89 4.23Pexieder 1986-87 6.04Meberg 19

5、82-88 9.02Prevalence of congenital heart malformation at birth第五頁，共十七頁。Prevalence of congenital heart malformation at birthRegional differences/ 1000 live birthsRegion Mean Range difference place Europe 6.67 3.20 Birmingham, UK 12.30 Florence, ItalyUSA 5.76 3.20 Bogalusa 8.56 San FranciscoCanada 3.9

6、7 2.17 Toronto 5.54 AlbertaOther countries 8.97 6.08 Guadeloupe第六頁，共十七頁。 Yearly fluctuation in Bohemian data from 1980 through 1989Year No. of malformation Prevalence/ 1000 646 7.04 547 6.39 568 6.771983 548 6.73 566 6.97 495 6.16 436 5.53 455 5.82 402 5.111980 367 4.80 Prevalence of congenital hear

7、t malformation at birth第七頁，共十七頁。 The prevalence was highest in October, and lowest in December ,June and July. The peak of the prevalence coincided with the epidemics of influenza in early pregnancy 8 and 9 months previously.There was a definite seasonal variation第八頁，共十七頁。Ratio of boys to girlsBoys

8、to girls with CHD: 51.9% to 48.1%A higher proportion of boys was found with : DORV (2.68: 1); HLHS (2.25 :1) cTGA ( 2.11 :1); A higher proportion of girls was found with:PDA (1 :1.66); Ebsteins malformation (1 :1.57)Common arterial trunk (1:1.22)第九頁，共十七頁。Distribution of congenital heart malformation

9、VSD 41.59%ASD 8.67%Aortic stenosis 7.77%Pulmonary stenosis 5.81%cTGA 5.39%Aortic coarctation 5.29%PDA 5.07% Greater than 5% of the overall number of malformation第十頁，共十七頁。Distribution of congenital heart malformation AVSD 4.00% HLHS 3.42% TOF 3.36%DORV, common arterial trunk and pulmonary atresia 1.0

10、5-1.37%TAPVC 0.80%Tricuspid 0.78%Ebstein malformation 0.44%Interrupted aortic arch 0.44%第十一頁，共十七頁。Spontaneous closure in 576 of 2092 recognized ventricular Septal defects, accounting for 27.5% of the cases第十二頁，共十七頁。Critical heart malformation in neonates,10 most frequent Number proportion of total M

11、alformations number seen(%)cTGA 102 84Pul atresia 39 74Coarctation 34 49HLHS 34 94Tricuspid atresia 13 77DORV 20 50VSD 8 8Common AT 8 50TOF 7 28Critical heart disease: which threaten life,which manifested by severve Congestive heart failure,deep cyanosis, or both symptoms第十三頁，共十七頁。Death rate of chil

12、dren born with CHD第十四頁，共十七頁。Survival in most frequent cardiac malformation CHD Number survival (%) at age of 1 5 15yrsVSD 2097 91 90 89ASD 436 94 93 93Aortic stenosis 391 90 89 88PS 292 96 96 96cTGA 271 62 56 54Coarctation 266 68 65 65PDA 255 91 91 91AVSD 201 62 55 54HLHS 172 0 0 0TOF 169 84 78 77第十五頁，共十七頁。Questionnaires, 1564例例8-13歲歲先心病患兒生存先心病患兒生存質(zhì)量質(zhì)量(zhling)調(diào)查調(diào)查 83.2% 未用任何藥未用任何藥 3.2% 體能差體能差 59.5% 可參加娛樂消遣性活動(dòng)可參加娛樂消遣性活動(dòng) 6.7%可參加競爭性的運(yùn)動(dòng)可參加競爭性的運(yùn)動(dòng) 35.5% 上學(xué)延遲上