Tyrosinase-Inhibitors-Modulators-MCE

1、 HYPERLINK https:/www.MedChemE/Targets/Tyrosinase.html TyrosinaseTyrosinase is a copper-containing metalloprotein belonging to the type-3 copper protein family, together with haemocyanins andcatechol oxidases. Tyrosinases are the catalysts in mammals responsible for the formation of melanin in skin

2、and hair color, as wellas browning in fruit and vegetables following cell damage.Tyrosinases are found in various prokaryotes as well as in plants, fungi, arthropods, and mammals and are responsible forpigmentation, wound healing, radiation protection, and primary immune response. Tyrosinases perfor

3、m two sequential enzymaticreactions: hydroxylation of monophenols and oxidation of diphenols to form quinones which polymerize spontaneously to melanin.In plants, sponges, and many invertebrates, tyrosinases are important for wound healing and primary immune responses; inarthropods, they play a role

4、 in sclerotization, and in bacteria, tyrosinases protect DNA from UV damage.www.MedChemE 1 HYPERLINK https:/www.MedChemE/Targets/Tyrosinase.html Tyrosinase HYPERLINK https:/www.MedChemE/Targets/Tyrosinase.html HYPERLINK https:/www.MedChemE/Targets/Tyrosinase.html Inhibitors HYPERLINK https:/www.MedC

5、hemE/Targets/Tyrosinase.html HYPERLINK https:/www.MedChemE/Targets/Tyrosinase.html & HYPERLINK https:/www.MedChemE/Targets/Tyrosinase.html HYPERLINK https:/www.MedChemE/Targets/Tyrosinase.html Modulators HYPERLINK https:/www.MedChemE/minus-taxifolin.html (-)-Taxifolin(-)-Dihydroquercetin) Cat. No.:

6、HY-N0136B HYPERLINK https:/www.MedChemE/r-trolox.html (R)-TroloxCat. No.: HY-101445A(-)-Taxifolin is the less active enantiomer ofTaxifolin. Taxifolin exhibits importantanti-tyrosinase activity. Taxifolin exhibitssignificant inhibitory activity against collagenasewith an IC value of 193.3 M.50(R)-Tr

7、olox is a vitamin E analogue and acompetitive tyrosinase inhibitor with a K value ofi0.83 mM and a ID value of 1.88 mM. The50(R)-Trolox has stronger tyrosinase affinity thanthe (S) enantiomer (K value of 0.61 mM).iPurity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mgPurity: 99.94%Clinic

8、al Data: No Development ReportedSize: 10 mM 1 mL, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/racemic-taxifolin.html ()-Taxifolin()-Dihydroquercetin) Cat. No.: HY-N0136A HYPERLINK https:/www.MedChemE/2-Hydroxy-4-methoxybenzaldehyde.html 2-Hydroxy-4-methoxybenzaldehydeCat. No.: HY-N0445()-Taxifolin (

9、)-Dihydroquercetin) is theracemate of Taxifolin. Taxifolin exhibitsimportant anti-tyrosinase activity. Taxifolinexhibits significant inhibitory activity againstcollagenase with an IC value of 193.3 M.502-Hydroxy-4-methoxybenzaldehyde, a chemicalcompound and an isomer of Vanillin, could be usedto syn

10、thesis Urolithin M7.Purity: 98%Clinical Data: No Development ReportedSize: 10 mgPurity: 99.90%Clinical Data: No Development ReportedSize: 100 mg HYPERLINK https:/www.MedChemE/2-Ketoglutaric_acid.html 2-Ketoglutaric HYPERLINK https:/www.MedChemE/2-Ketoglutaric_acid.html HYPERLINK https:/www.MedChemE/

11、2-Ketoglutaric_acid.html acid(Alpha-Ketoglutaric acid) Cat. No.: HY-W013636 HYPERLINK https:/www.MedChemE/alpha-ketoglutaric-acid-sodium-salt.html 2-Ketoglutaric HYPERLINK https:/www.MedChemE/alpha-ketoglutaric-acid-sodium-salt.html HYPERLINK https:/www.MedChemE/alpha-ketoglutaric-acid-sodium-salt.h

12、tml acid HYPERLINK https:/www.MedChemE/alpha-ketoglutaric-acid-sodium-salt.html HYPERLINK https:/www.MedChemE/alpha-ketoglutaric-acid-sodium-salt.html Sodium(Alpha-Ketoglutaric acid Sodium) Cat. No.: HY-W013636A2-Ketoglutaric acid (Alpha-Ketoglutaric acid) isan intermediate in the production of ATP

13、or GTP inthe Krebs cycle. 2-Ketoglutaric acid also acts asthe major carbon skeleton fornitrogen-assimilatory reactions.2-Ketoglutaric acid Sodium (Alpha-Ketoglutaricacid Sodium) is an intermediate in the productionof ATP or GTP in the Krebs cycle. 2-Ketoglutaricacid Sodium also acts as the major car

14、bon skeletonfor nitrogen-assimilatory reactions.Purity: 95.0%Clinical Data: No Development ReportedSize: 500 mg, 1 gPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/2-methoxycinnamic-acid.html 2-Methoxycinnamic HYPERLINK https:/www.MedChemE/2-methoxycin

15、namic-acid.html HYPERLINK https:/www.MedChemE/2-methoxycinnamic-acid.html acid HYPERLINK https:/www.MedChemE/2-methoxycinnamic-acid.html HYPERLINK https:/www.MedChemE/3-4-dihydroxyacetophenone.html 3,4-DihydroxyacetophenoneCat. No.: HY-N1386(3,4-DHAP) Cat. No.: HY-N17752-Methoxycinnamic acid is a no

16、ncompetitiveinhibitor of tyrosinase.3,4-Dihydroxyacetophenone (3,4-DHAP), isolatedfrom Picea Schrenkiana Needles exhibits a strongsuppressive action against tyrosinase activity,with an IC of 10 M. 3,4-Dihydroxyacetophenone50(3,4-DHAP) is a vasoactive agent and antioxidant.Purity: 98.0%Clinical Data:

17、 No Development ReportedSize: 10 mM 1 mL, 10 mg, 50 mg, 100 mgPurity: 99.83%Clinical Data: No Development ReportedSize: 500 mg HYPERLINK https:/www.MedChemE/3-4-dimethoxyphenol.html 3,4-Dimethoxyphenol HYPERLINK https:/www.MedChemE/3-4-dimethoxyphenol.html HYPERLINK https:/www.MedChemE/3-2-4-dihydro

18、xyphenyl-propanoic-acid.html 3-(2,4-Dihydroxyphenyl)propanoic HYPERLINK https:/www.MedChemE/3-2-4-dihydroxyphenyl-propanoic-acid.html HYPERLINK https:/www.MedChemE/3-2-4-dihydroxyphenyl-propanoic-acid.html acidCat. No.: HY-N1780 Cat. No.: HY-N17503,4-Dimethoxyphenol is a plant-derivedphenylpropanoid

19、 compound and can use as awhitening agent in cosmetics. 3,4-Dimethoxyphenolhas tyrosinase-inhibiting activity.3,4-Dimethoxyphenol has potent antioxidant effectisolated from the bacterial fermentation broth.3-(2,4-Dihydroxyphenyl)propanoic acid (DPPacid) isa potent and competitive tyrosinase inhibito

20、r,inhibits L-Tyrosine and DL-DOPA with an IC and a50K of 3.02 M and 11.5 M, respectively.iPurity: 99.97%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 25 mg, 100 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLI

21、NK https:/www.MedChemE/3-o-ethyl-l-ascorbic-acid.html 3-O-Ethyl-L-ascorbic HYPERLINK https:/www.MedChemE/3-o-ethyl-l-ascorbic-acid.html HYPERLINK https:/www.MedChemE/3-o-ethyl-l-ascorbic-acid.html acidCat. No.: HY-W003607 HYPERLINK https:/www.MedChemE/4-Butylresorcinol.html 4-Butylresorcinol(Butylre

22、sorcinol) Cat. No.: HY-1073693-O-Ethyl-L-ascorbic acid, a stable vitamin Cderivative, is a cosmetic tyrosinase tnhibitor witha whitening capacity. 3-O-Ethyl-L-ascorbic acidalso has antioxidant abilities.4-Butylresorcinol is a phenol derivative which caninhibit tyrosinase with IC of 11.27 M.50Purity:

23、 98.0%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 500 mgPurity: 98.23%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/5-feruloylquinic-acid.html 5-Feruloylquinic HYPERLINK https:/www.MedChemE/5-feruloylquinic-acid.html HYPERLINK https:/

24、www.MedChemE/5-feruloylquinic-acid.html acidCat. No.: HY-N7929 HYPERLINK https:/www.MedChemE/Arbutin.html Arbutin(-Arbutin) Cat. No.: HY-N01925-Feruloylquinic acid (5-FQA) possessesantioxidative effects and tyrosinase inhibitoryactivities.Arbutin (-Arbutin) is a competitive inhibitor oftyrosinase in

25、 melanocytes, with K values ofappi1.42 mM for monophenolase; 0.9 mM for diphenolase.Arbutin is also used as depigmenting agents.Purity: 99.0%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mgPurity: 98.0%Clinical Data: Phase 2Size: 10 mM 1 mL, 500 mg, 5 g, 10 g HYPERLINK https:/www.MedChe

26、mE/arbutin-d4.html Arbutin-d4(-Arbutin-d4) Cat. No.: HY-N0192S HYPERLINK https:/www.MedChemE/benzoyloxypaeoniflorin.html BenzoyloxypaeoniflorinCat. No.: HY-N2101Arbutin-d4 is deuterium labeled Arbutin. Arbutin(-Arbutin) is a competitive inhibitor oftyrosinase in melanocytes, with Kiapp values of1.42

27、 mM for monophenolase; 0.9 mM for diphenolase.Arbutin is also used as depigmenting agents.Benzoyloxypaeoniflorin, isolated from the root ofPaeonia suffruticosa, is a tyrosinase inhibitoragainst mushroom tyrosinase with IC of 0.453 mM.50Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 m

28、gPurity: 98%Clinical Data: No Development ReportedSize: 5 mg HYPERLINK https:/www.MedChemE/benzylacetone.html Benzylacetone HYPERLINK https:/www.MedChemE/benzylacetone.html HYPERLINK https:/www.MedChemE/calcium-2-oxoglutarate.html Calcium HYPERLINK https:/www.MedChemE/calcium-2-oxoglutarate.html HYP

29、ERLINK https:/www.MedChemE/calcium-2-oxoglutarate.html 2-oxoglutarate(4-Penylbutan-2-one) Cat. No.: HY-W015616Cat. No.: HY-W013636BBenzylacetone is an aromatic compound fromagarwood. Benzylacetone exhibits potent andreversible antityrosinase (mushroom) activity withIC s of 2.8 mM and 0.6 mM for mono

30、phenolase and50diphenolase, respectively. Benzylacetone hasappetite-enhancing and locomotor-reducing effects.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgCalcium 2-oxoglutarate is an intermediate in theproduction of ATP or GTP in the Krebs cycle.Calcium 2-oxoglutarate also acts a

31、s the majorcarbon skeleton for nitrogen-assimilatoryreactions. Calcium 2-oxoglutarate is a reversibleinhibitor of tyrosinase (IC =15 mM).50Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/chetoseminudin-b.html Chetoseminudin HYPERLINK https:/www.MedChem

32、E/chetoseminudin-b.html HYPERLINK https:/www.MedChemE/chetoseminudin-b.html B HYPERLINK https:/www.MedChemE/chetoseminudin-b.html HYPERLINK https:/www.MedChemE/chimonanthine.html ChimonanthineCat. No.: HY-N10286(-)-Chimonanthine) Cat. No.: HY-N5118Chetoseminudin B possesses mushroom tyrosinaseinhibi

33、tory activity with IC of 31.7 M.50Chimonanthine is an alkaloid of Chimonanthuspraecox, inhibits tyrosinase and tyrosine-relatedprotein-1 mRNA expression, amd inhibitsmelanogenesis.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize:

34、1 mg, 5 mgwww.MedChemE 3 HYPERLINK https:/www.MedChemE/cis-mulberroside-a.html cis-Mulberroside HYPERLINK https:/www.MedChemE/cis-mulberroside-a.html HYPERLINK https:/www.MedChemE/cis-mulberroside-a.html A(Mulberroside D) Cat. No.: HY-N0619A HYPERLINK https:/www.MedChemE/d-tyrosine.html D-TyrosineCa

35、t. No.: HY-Y0444cis-Mulberroside A (Mulberroside D) is thecis-isomer of Mulberroside A. Mulberroside A isone of the main bioactive constituent in mulberry(Morus alba L.).D-Tyrosine is the D-isomer of tyrosine. D-Tyrosinenegatively regulates melanin synthesis byinhibiting tyrosinase activity. D-Tyros

36、ine inhibitsbiofilm formation and trigger the self-dispersalof biofilms without suppressing bacterial growth.Purity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mgPurity: 98.0%Clinical Data: No Development ReportedSize: 500 mg HYPERLINK https:/www.MedChemE/d-tyrosine-d2.html D-Tyr

37、osine-d2 HYPERLINK https:/www.MedChemE/d-tyrosine-d2.html HYPERLINK https:/www.MedChemE/d-tyrosine-d4.html D-Tyrosine-d4Cat. No.: HY-Y0444S Cat. No.: HY-Y0444S1D-Tyrosine-d2 is the deuterium labeled D-Tyrosine.D-Tyrosine is the D-isomer of tyrosine. D-Tyrosinenegatively regulates melanin synthesis b

38、yinhibiting tyrosinase activity.D-Tyrosine-d4 is the deuterium labeled D-Tyrosine.D-Tyrosine is the D-isomer of tyrosine. D-Tyrosinenegatively regulates melanin synthesis byinhibiting tyrosinase activity.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No De

39、velopment ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/d-tyrosine-d7.html D-Tyrosine-d7 HYPERLINK https:/www.MedChemE/d-tyrosine-d7.html HYPERLINK https:/www.MedChemE/Deoxyarbutin.html DeoxyarbutinCat. No.: HY-Y0444S2 Cat. No.: HY-B1461D-Tyrosine-d7 is the deuterium labeled D-Tyrosine.D-Ty

40、rosine is the D-isomer of tyrosine. D-Tyrosinenegatively regulates melanin synthesis byinhibiting tyrosinase activity.Deoxyarbutin is a new effective lighteningredient, can effectively inhibit tyrosinaseactivity and melanin synthesis to get significantand lasting lightening effect.Purity: 98%Clinica

41、l Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 100 mg, 500 mg HYPERLINK https:/www.MedChemE/dihydroaltenuene-b.html Dihydroaltenuene HYPERLINK https:/www.MedChemE/dihydroaltenuene-b.html HYPERLINK https:/www.MedChemE/dihydroaltenuene

42、-b.html B HYPERLINK https:/www.MedChemE/dihydroaltenuene-b.html HYPERLINK https:/www.MedChemE/dihydromorin.html DihydromorinCat. No.: HY-N10219 Cat. No.: HY-N3748Dihydroaltenuene B is a potent mushroomtyrosinase inhibitor with an IC of 38.33 M.50Dihydroaltenuene B shows the hydrogen bondinginteracti

43、ons between the 3-OH and 4-OH and theHis244, Met280 and Gly281 residues of tyrosinase.Dihydromorin, a natural flavanonol compound, is atyrosinase inhibitor.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK htt

44、ps:/www.MedChemE/glabrene.html Glabrene HYPERLINK https:/www.MedChemE/glabrene.html HYPERLINK https:/www.MedChemE/2-Hydroxyacetic_acid.html Glycolic HYPERLINK https:/www.MedChemE/2-Hydroxyacetic_acid.html HYPERLINK https:/www.MedChemE/2-Hydroxyacetic_acid.html acidCat. No.: HY-N3943 Cat. No.: HY-W01

45、5967Glabrene, an isoflavene derived from licoriceroot, shows estrogen-like activity. Glabrene is atyrosinase inhibitor with an IC of 3.5 M.50Glycolic acid is an inhibitor of tyrosinase,suppressing melanin formation and lead to alightening of skin colour.Purity: 98%Clinical Data: No Development Repor

46、tedSize: 5 mgPurity: 97.0%Clinical Data: Phase 4Size: 10 mM 1 mL, 500 mg, 1 g4 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/glycolic-acid-d2.html Glycolic HYPERLINK https:/www.MedChemE/glycolic-acid-d2.html HYPERLINK https:/www.MedChemE/glycolic-acid-d2.html

47、 acid-d2 HYPERLINK https:/www.MedChemE/glycolic-acid-d2.html HYPERLINK https:/www.MedChemE/gnetol.html GnetolCat. No.: HY-W015967S Cat. No.: HY-126052Glycolic acid-d2 is the deuterium labeled Glycolicacid. Glycolic acid is an inhibitor of tyrosinase,suppressing melanin formation and lead to alighten

48、ing of skin colour.Gnetol is a phenolic compound isolated from theroot of Gnetum ula Brongn. Gnetol potentlyinhibits COX-1 (IC of 0.78 M) and .Gnetol is a potent tyrosinase inhibitor with an50 HDACIC of 4.5 M for murine tyrosinase and50suppresses melanin biosynthesis.Purity: 98%Clinical Data: No Dev

49、elopment ReportedSize: 1 mg, 5 mgPurity: 98.0%Clinical Data: No Development ReportedSize: 5 mg HYPERLINK https:/www.MedChemE/isoastilbin.html Isoastilbin HYPERLINK https:/www.MedChemE/isoastilbin.html HYPERLINK https:/www.MedChemE/isolindleyin.html IsolindleyinCat. No.: HY-N4005 Cat. No.: HY-N6244Is

50、oastilbin is a dihydroflavonol glycosidecompound in Rhizoma Smilacis glabrae andAstragalus membranaceus. Isoastilbin inhibitsglucosyltransferase (GTase) with an IC value of5054.3 g/mL, and also inhibits tyrosinase activity.Isolindleyin, a butyrophenone, is a tyrosinaseinhibitor, with a K of 54.8 M f

51、or humandtyrosinase. Isolindleyin exhibitsanti-inflammatory, analgesic and anti-melanogenicactivities.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg HYPERLINK https:/www.MedChemE/kurarinol.html KurarinolCat.

52、No.: HY-122933 HYPERLINK https:/www.MedChemE/kushenol-a.html Kushenol HYPERLINK https:/www.MedChemE/kushenol-a.html HYPERLINK https:/www.MedChemE/kushenol-a.html A(Leachianone E) Cat. No.: HY-N2278Kurarinol is a flavanone found in the root ofSophora flavescens. Kurarinol is a competitivetyrosinase i

53、nhibitor, with IC of 0.1 M for50mushroom tyrosinase.Kushenol A (Leachianone E) is isolated from theroot of Sophora flavescent. Kushenol A is anon-competitive tyrosinase inhibitor to block theconversion of L-tyrosine to L-DOPA, shows IC and50Kvalues of 1.1 M and 0.4 M, respectively.iPurity: 98%Clinic

54、al Data: No Development ReportedSize: 5 mg, 10 mg, 25 mgPurity: 99.84%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg HYPERLINK https:/www.MedChemE/lavendustin-b.html Lavendustin HYPERLINK https:/www.MedChemE/lavendustin-b.html HYPERLINK https:/www.MedChemE/lavendustin-b.html B H

55、YPERLINK https:/www.MedChemE/lavendustin-b.html HYPERLINK https:/www.MedChemE/leptosin-d.html Leptosin HYPERLINK https:/www.MedChemE/leptosin-d.html HYPERLINK https:/www.MedChemE/leptosin-d.html DCat. No.: HY-108935 Cat. No.: HY-N10287Lavendustin B is an inhibitor of HIV-1 integraseinteraction with

56、LEDGF/p75 with an IC of 94.0750M. Lavendustin B is an ATP-competitive GLUT1inhibitor with a K of 15 M. Lavendustin B isialso a weak inhibitor of tyrosine kinases.Leptosin D, a thiodiketopiperazine alkaloid, is amushroom tyrosinase inhibitor, with an IC of5028.4 M.Purity: 98.04%Clinical Data: No Deve

57、lopment ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/methyl-cinnamate.html Methyl HYPERLINK https:/www.MedChemE/methyl-cinnamate.html HYPERLINK https:/www.MedChemE/methyl-cinnamate.html cinn

58、amate HYPERLINK https:/www.MedChemE/methyl-cinnamate.html HYPERLINK https:/www.MedChemE/methyl-rosmarinate.html Methyl HYPERLINK https:/www.MedChemE/methyl-rosmarinate.html HYPERLINK https:/www.MedChemE/methyl-rosmarinate.html rosmarinate(Methyl 3-phenylpropenoate) Cat. No.: HY-W017212Cat. No.: HY-N

59、3266Methyl cinnamate (Methyl 3-phenylpropenoate), anactive component of Zanthoxylum armatum, isa widely used natural flavor compound. Methylcinnamate (Methyl 3-phenylpropenoate) possessesantimicrobial activity and is a tyrosinaseinhibitor that can prevent food browning.Methyl rosmarinate is a noncom

60、petitive tyrosinaseinhibitor which is isolated from Rabdosia serra,with an IC of 0.28 mM for mushroom tyrosinase,50and also inhibits a-glucosidase.Purity: 99.39%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 500 mgPurity: 99.89%Clinical Data: No Development ReportedSize: 5 mg, 10 mgwww.MedC